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Mark Sebastian Sulkowski, M.D.

Photo of Dr. Mark Sebastian Sulkowski, M.D.
  • Chief, Division of Infectious Diseases Johns Hopkins Bayview Medical Center
  • Professor of Medicine
Male

Expertise

Acute or Chronic Viral Hepatitis, HBV/HIV Coinfection, HCV/HIV Coinfection, Hepatitis B (HBV), Hepatitis C (HCV), Infectious Disease ...read more

Locations

The John G. Bartlett Specialty Practice

1717 E. Monument Street
Baltimore, MD 21287 map
Phone: 443-997-1900 | Fax: 443-287-4173

Johns Hopkins Rockland Physician Practice and Research Group

10751 Falls Road
Falls Concourse Suite 412
Lutherville, MD 21093 map

Background

Mark Sulkowski, MD, is a Professor of Medicine at the Johns Hopkins University School of Medicine and the Director of the Division of Infectious Diseases Johns Hopkins Bayview Medical Center.  He also serves as the Medical Director of the Viral Hepatitis Center in the Divisions of Infectious Diseases and Gastroenterology/Hepatology in the Department of Medicine and is the Associate Dean for Research in the Capital Region (CAPRES).   He received his MD from Temple University School of Medicine, Philadelphia, PA (1992), pursued training in Internal Medicine at Duke University School of Medicine, Durham, NC (1995) and completed his Fellowship in Infectious Diseases (1998) at the Johns Hopkins University School of Medicine.

Prof. Sulkowski has been the principal investigator for more than 120 clinical trials related to the management of viral hepatitis B and C in persons with and without HIV co-infection.  He was the global principal investigator for more than a dozen trials, including the largest clinical trial of agents for the treatment of hepatitis C (New England Journal of Medicine, 2009) and the vanguard study of combination therapy with direct inhibitors of the HCV NS5A and NS5B non-structural proteins (New England Journal of Medicine, 2014). He is the past-chair of the Hepatitis Transformative Sciences Group of the National Institute of Health-funded adult AIDS Clinical Trials Group (ACTG) where he led translational studies of liver disease, namely hepatitis B and C virus.   He is an elected member of the American Society for Clinical Investigation (2011) and the American Association of Physicians (2017).

Prof. Sulkowski is a member of numerous professional societies including the American Association for the Study of Liver Diseases (AASLD), the European Association for the Study of the Liver (EASL), and the Infectious Diseases Society of America (IDSA).  With more than 300 peer-reviewed articles, he is widely published with works in Annals of Internal Medicine, New England Journal of Medicine, JAMA, Clinical Infectious Diseases, Journal of Hepatology, and Hepatology. In 2017, 2018 and 2019, he was named as a Highly Cited Researcher (Clarivate Analytics) defined as the being in the top 1% of global researchers in 21 fields of the sciences and social sciences based on the number of citations for papers.  As an invited lecturer, he has been frequently invited to present at major national and international medical congresses and has educated learners in more than 25 countries. 

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Titles

  • Chief, Division of Infectious Diseases Johns Hopkins Bayview Medical Center
  • Associate Dean, Research in the Capital Region
  • Medical Director, Viral Hepatitis Center
  • Professor of Medicine

Departments / Divisions

Centers & Institutes

Education

Degrees

  • MD, Temple University School of Medicine (1992)

Residencies

  • Duke University School of Medicine / Internal Medicine (1995)

Fellowships

  • Johns Hopkins University School of Medicine / Infectious Diseases (1998)

Board Certifications

  • American Board of Internal Medicine / Infectious Disease (1997)
  • American Board of Internal Medicine / Internal Medicine (1995)

Research & Publications

Research Summary

An infectious disease expert, Dr. Sulkowski has been the principal investigator for numerous clinical trials related to the management of viral hepatitis, including novel agents. He is the Chair of the Hepatitis Transformative Sciences Group, National Institute of Allergy and Infectious Diseases Adult AIDS Clinical Trials Group.

Clinical Trial Keywords

hepatitis B, hepatitis C

Selected Publications

View all on Pubmed

Rockstroh JK, Nelson M, Katlama C, Lalezari J, Mallolas J, Bloch M, Matthews GV, Saag MS, Zamor PJ, Orkin C, Gress J, Klopfer S, Shaughnessy M, Wahl J, Nguyen BY, Barr E, Platt HL, Robertson MN, Sulkowski M. "Efficacy and safety of grazoprevir (MK-5172) and elbasvir (MK-8742) in patients with hepatitis C virus and HIV co-infection (C-EDGE CO-INFECTION): a non-randomised, open-label trial." Lancet HIV. 2015 Aug;2(8):e319-27. doi: 10.1016/S2352-3018(15)00114-9. Epub 2015 Jul 9.

Negro F, Forton D, Craxì A, Sulkowski MS, Feld JJ, Manns MP. "Extrahepatic morbidity and mortality of chronic hepatitis C." Gastroenterology. 2015 Aug 28. pii: S0016-5085(15)01203-2. doi: 10.1053/j.gastro.2015.08.035. [Epub ahead of print] Review.

Balagopal A, Barin B, Quinn J, Rogers R, Sulkowski MS, Stock PG. "Immunologic predictors of liver transplantation outcomes in HIV-HCV co-infected persons." PLoS One. 2015 Aug 27;10(8):e0135882. doi: 10.1371/journal.pone.0135882. eCollection 2015.

Lawitz E, Jacobson IM, Nelson DR, Zeuzem S, Sulkowski MS, Esteban R, Brainard D, McNally J, Symonds WT, McHutchison JG, Dieterich D, Gane E. "Development of sofosbuvir for the treatment of hepatitis C virus infection." Ann N Y Acad Sci. 2015 Jul 31. doi: 10.1111/nyas.12832. [Epub ahead of print]

Naggie S, Cooper C, Saag M, Workowski K, Ruane P, Towner WJ, Marks K, Luetkemeyer A, Baden RP, Sax PE, Gane E, Santana-Bagur J, Stamm LM, Yang JC, German P, Dvory-Sobol H, Ni L, Pang PS, McHutchison JG, Stedman CA, Morales-Ramirez JO, Bräu N, Jayaweera D, Colson AE, Tebas P, Wong DK, Dieterich D, Sulkowski M; ION-4 Investigators. "Ledipasvir and Sofosbuvir for HCV in Patients Coinfected with HIV-1." N Engl J Med. 2015 Aug 20;373(8):705-13. doi: 10.1056/NEJMoa1501315. Epub 2015 Jul 21.

Activities & Honors

Honors

  • Elected Member, American Society for Clinical Investigation (ASCI), 2011
  • Alpha Omega Alpha, Temple University School of Medicine, 1991
  • Elected Member, Association of American Physicians, 2018

Memberships

  • American Association for the Study of Liver Diseases
  • European Association for the Study of the Liver
  • Infectious Diseases Society of America

Videos & Media

Recent News Articles and Media Coverage

Online Patient Education Seminar: A Cure for Hepatitis C – Discover Your Treatment Options

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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