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Expertise: Cardiac Sarcoidosis, Cardiomyopathy, Cardiovascular Disease, Cardiovascular Disease in Women, Cardiovascular Diseases, Chemotherapy-Induced Cardiomyopathy, Congestive Heart Failure (CHF), Heart Disease, Heart Failure, Heart Transplant, Hypertrophic Cardiomyopathy, Ischemic Heart Disease, Mechanical Circulatory Support, Peripartum Cardiomyopathy ...read more
Research Interests: Obesity and congestive heart failure; Leptin signaling and cardiac hypertrophy; Beta 3 adrenergic signaling and cardiac remodeling; Cardioprotective effect of beta-3 adrenergic receptor signaling ...read more
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APPOINTMENT PHONE: 410-964-5303
5450 Knoll North Drive Columbia, MD 21045
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Phone: 410-964-5303 | Fax: 410-964-5329
Dr. Barouch is currently Associate Professor of Medicine in the Division of Cardiology and a member of the Advanced Heart Failure and Cardiac Transplantation group at the Johns Hopkins University School of Medicine. Dr. Barouch received her undergraduate degree from Harvard University in 1992 and her medical degree from Johns Hopkins in 1996. She continued at Johns Hopkins for residency training in Internal Medicine, completed in 1999, and fellowship in Cardiovascular Disease and Advanced Heart Failure/Transplant, completed in 2003.
Dr. Barouch has a longstanding interest in women’s cardiovascular health – particularly in how some cardiac conditions affect women differently or present with distinctive symptoms. She also has specific expertise in peripartum cardiomyopathy, heart failure after cancer treatment, and the role of obesity in the development of congestive heart failure. She has been a member of the Johns Hopkins cardiology faculty since 2003 and has performed extensive independent research within the Cardiovascular Division. Dr. Barouch cares for general cardiology and heart failure patients at her primary clinical location in Columbia, Maryland, where she is working to establish a Women’s Heart Health Program.
She believes that educating people about heart disease, medications and lifestyle changes, including healthy eating habits and regular exercise, is critically important in helping her patients understand how to achieve and maintain wellness and feel in control of their cardiovascular health. She is an avid runner and triathlete herself, competing in several triathlons and other races per year, as well as the occasional marathon.
Dr. Barouch’s laboratory is focused on defining the peripheral cardiovascular effects of the adipocytokine leptin, which is a key to the understanding of obesity-related cardiovascular disease. Interestingly, many of the hormonal abnormalities seen in obesity are mimicked in heart failure. The research program will enhance the understanding of metabolic signaling in the heart, including the effects of leptin, exercise, sex hormones, and downstream signaling pathways on metabolism and cardiovascular function. The lab also is working to determine the precise role of the “metabolic” beta-3 adrenergic receptor (ß3AR) in the heart and define the extent of its protective effect in obesity and in heart failure, including its role in maintaining nitric oxide synthase (NOS) coupling. Ultimately, this work will enable the exploration of a possible therapeutic role of ß3AR agonists and re-coupling of NOS in preventing adverse ventricular remodeling in obesity and in heart failure.
Barouch LA, Harrison RW, Skaf MW, Rosas GO, Cappola TP, Kobeissi ZA, Hobai IA, Lemmon CA, Burnett AL, O'Rourke B, Rodriguez ER, Huang PL, Lima JAC, Berkowitz DE, Hare JM. Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms. Nature. 2002; 416:337-339
Barouch LA, Gao D, Chen L, Miller KL, Xu W, Phan AC, Kittleson MK, Minhas KM, Berkowitz DE, Wei C, Hare JM. Cardiac myocyte apoptosis is associated with increased DNA damage and decreased survival in murine models of obesity. Circulation Research. 2006; 98(1):119-24
Yang R, Sikka G, Larson J, Watts VL, Niu X, Ellis CL, Miller KL, Camara A, Reinke C, Savransky V, Polotsky VY, O'Donnell CP, Berkowitz DE, Barouch LA. Restoring leptin signaling reduces hyperlipidemia and improves vascular stiffness induced by chronic intermittent hypoxia. American J Physiol Heart Circ Physiol. 2011; 300(4):H1467-76
Niu X, Watts VL, Cingolani OH, Sivakumaran V, Leyton-Mange JS, CL, Miller KL, Vandegaer K, Bedja D, Gabrielson KL, Paolocci N, Kass DA, Barouch LA. Cardioprotective Effect of Beta-3 Adrenergic Receptor Agonism: Role of Neuronal Nitric Oxide Synthase. JACC. 2012; 59(22):1979-87
Watts VL, Sepulveda FM, Cingolani OH, Ho AS, Niu X, Kim R, Miller KL, Vandegaer K, Bedja D, Gabrielson KL, Rameau G, O'Rourke B, Kass DA, Barouch LA. Anti-hypertrophic and anti-oxidant effect of beta3-adrenergic stimulation in myocytes requires differential neuronal NOS phosphorylation. J Mol Cell Cardiol. 2013; 62:8-17
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