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Ned Charlton Sacktor, M.D.

Photo of Dr. Ned Charlton Sacktor, M.D.
  • Professor of Neurology


Behavioral Disorders in Dementia, Cognitive Decline in Older Adults, Dementia, Neurology

Research Interests

HIV associated neurocognitive disorders


Johns Hopkins Bayview Medical Center

Appointment Phone: 410-550-5624
301 Mason Lord Drive
Baltimore, MD 21224 map
Phone: 410-550-1045 | Fax: 410-550-0539

The Johns Hopkins Hospital (Main Entrance)

Appointment Phone: 410-955-9441
1800 Orleans St.
Sheikh Zayed Tower
Baltimore, MD 21287 map


Dr. Ned Sacktor focuses on general neurology with a special interest in dementia and behavioral neurology.

Dr. Ned Sacktor received his medical degree from the University of Pennsylvania School of Medicine. He then completed a residency in neurology at the Neurological Institute of New York, Columbia Presbyterian Hospital. He went on to complete a behavioral neurology fellowship at the same institution. more


  • Professor of Neurology

Departments / Divisions

Centers & Institutes

Research & Publications

Research Summary

Dr. Sacktor's research focuses primarily on the cognitive manifestations of HIV infection. These investigations include clinical, epidemiological and neuroimaging studies. He also focuses on trials of therapeutic agents for the treatment of HIV-associated dementia.

Clinical Trial Keywords

HIV dementia

Selected Publications

Selected Peer-reviewed Publications (in chronological order)
Sacktor, N., Bacellar, H., Hoover, D.R., Nance-Sproson, T.E., Selnes, O.A., Miller, E.N., Dal Pan, G.J., Kleeberger, C., Brown, A., Saah, A., McArthur, J.C. Psychomotor slowing in HIV infection: a predictor of dementia, AIDS, and death. J Neurovirology 1996:2;404-410.
Sacktor, N. (Corresponding author). The Dana Consortium on the Therapy for HIV Dementia and Related Cognitive Disorders. A randomized, double-blind, placebo-controlled trial of deprenyl and thioctic acid in HIV associated cognitive impairment. Neurology 1998;50:645-651.
Sacktor, N.C., Lyles, R.H., Skolasky, R.L., Anderson, D.E., McArthur, J.C., McFarlane, G., Selnes, O.A., Becker, J.T., Cohen, B., Wesch, J., Miller, E.N. Combination antiretroviral therapy improves psychomotor speed performance In HIV+ homosexual men. Neurology 1999;52:1640-1647.
Sacktor, N., Schifitto, G., McDermott, M.P., Marder, K., McArthur, J.C., Kieburtz, K. Transdermal selegiline in HIV-associated cognitive impairment: a pilot, placebo-controlled study. Neurology 2000;54:233-235.
Sacktor, N., Lyles, R., Skolasky R., Kleeberger, C., Selnes, O.A., Miller, E.N., Becker, J.T., Cohen, B., McArthur, J.C., and the Multicenter AIDS Cohort Study. HIV-associated neurological disease incidence changes: Multicenter AIDS Cohort Study, 1990-1998. Neurology 2001;56:257-260.
Sacktor, N., McDermott, M.P., Marder, K., Schifitto, G., Selnes, O.A., McArthur, J.C., Stern, Y., Albert, S., Palumbo,D.,Kieburtz, K., Marcaida, J., Cohen, B., Epstein, L. HIV associated cognitive impairment before and after the advent of combination therapy. J NeuroVirology 2002;8:136-142.
Sacktor, N., Haughey, N., Cutler, R., Tamara, A., Turchan, J., Pardo, C., Vargas, D., Nath, A. Novel markers of oxidative stress in actively progressive HIV dementia. J Neuroimmunol 2004;157:176-184.
Sacktor, N., Wong, M., Nakasujja, N., Skolasky, R., Selnes, O., Musisi, S., Robertson, K., McArthur, J., Ronald, A., Katabira, E. The International HIV Dementia Scale: a new rapid screening test for HIV dementia. AIDS 2005 19;1367-1374.
Sacktor, N., Skolasky, R., Selnes, O., Watters, M., Poff, P., Shiramizu, B., Shikuma, C., Valcour, V. Neuropsychological test profile differences between young and old HIV+ individuals. J Neurovirology 2007;13:203-209.
Sacktor, N, Nakasujja, N., Robertson, K., Clifford, D. HIV-associated cognitive impairment in Sub-Saharan Africa: the potential impact of clade diversity. Nature Clinical Practice Neurology 2007 Aug;3(8) 436-443.
Sacktor, N, Nakasujja, N., Skolasky, R., Robertson, K., Musisi, S., Ronald, A., Katabira, E., Clifford, D. B. Benefits and risks of stavudine therapy for HIV associated neurological complications in Uganda. Neurology 2009;72:165-170.
Sacktor, N., Nakasujja, N., Skolasky, R., Rezapour, M., Robertson, K., Musisi, S., Katabira, E., Ronald, A., Clifford, D., Laeyendecker, O., Quinn, T. HIV subtype D is associated with dementia compared to subtype A in immunosuppressed individuals at risk for cognitive impairment in Kampala, Uganda. Clin Inf Dis 2009;49:780-786.
Mohamed, M.A., Barker, P.B., Skolasky, R.L., Moxley, R.T., Pomper, M.G., Sacktor, N.C. Decreased brain Glx levels in HIV dementia: a 3 tesla MR spectroscopy study. MRI 2010;1251-1257.
Sacktor, N., Skolasky, R.L., Cox, C., Selnes, O., Becker, J.T., Cohen, B., Martin, E., Miller, E., for the Multicenter AIDS Cohort Study (MACS). Longitudinal psychomotor speed performance in HIV+ individuals: impact of age and serostatus. J NeuroVirology 2010; 335-341.
Gandhi,N; Moxley R; Creighton,J.; Vornbrock Roosa,H; Selnes,O.; McArthur J.C.; Sacktor N. Comparison of scales to evaluate the progression of HIV-associated neurocognitive disorder. HIV Therapy 2010 4: 3:371-379.
Sacktor, N., Miyahara, S., Deng, L., Evans, S., Schifitto, G., Cohen, B.A., Paul, R., Robertson, K., Jarocki, B., Scarsi, K., Coombs, R.W., Zink, M.C., Nath, A., Smith, E., Ellis, R.J., Singer, E., Weihe, J., McCarthy, S., Hosey, L., Clifford, D.B., and the ACTG 5235 team. Minocycline treatment for HIV-associated cognitive impairment: results from a randomized trial. Neurology 2011 (in press).

Activities & Honors


  • Summa Cum Laude, Phi Beta Kappa, Harvard College, 1984
  • President, Maryland Neurological Society, 1997 - 1998
  • Member, Neurologic AIDS Research Consortium Leadership Committee, 2004
  • Dementia Focus Group Chairman, Adult AIDS Clinical Trials Group, 2004 - 2005
  • Neurology Subcommittee Chairman, Adult AIDS Clinical Trials Group, 2006 - 2007
  • Member, World Neurology Foundation Board of Directors, 2009


  • American Academy of Neurology
  • American Neurological Association

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