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Stephen Clyde Yang, M.D.
Associate Vice Chair for Faculty Development
Professor of Surgery
Expertise: Chest Trauma Surgery, Emphysema, Esophageal Cancer, Esophageal Cancer Surgery, Fibrosis, Lung Cancer, Lung Cancer Surgery, Lung Transplant, Lung Volume Reduction Surgery for Emphysema , Mediastinal Masses, Mesothelioma, Pleural Diseases, Surgery, Thoracic Surgery, Video Assisted Thoracic Surgery (VATS) ...read more
Research Interests: Development of molecular markers for early diagnosis of lung cancer; Development of molecular markers for early diagnosis of recurrent lung cancer following surgical resection; Molecular biology of mesothelioma; Detection of teleomerase activity as a guide for the presence of lung cancer ...read more
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The Johns Hopkins Hospital (Main Entrance)
Appointment Phone: 443-997-1508
1800 Orleans St.
Sheikh Zayed Tower
Baltimore, MD 21287 map
Johns Hopkins Bayview Medical Center
Appointment Phone: 443-997-1508
4940 Eastern Avenue
Baltimore, MD 21224 map
Dr. Stephen C. Yang is a professor of surgery and medical oncology at Johns Hopkins University School of Medicine and The Johns Hopkins Hospital. In October 2008 he was named the first recipient of The Arthur B. and Patricia B. Modell Professor in Thoracic Surgery.
Dr. Yang is an extreme supporter of medical students, being the only surgeon (amongst 20 chosen from the School of Medicine) for the medical student advisory Colleges system, and is the faculty sponsor for the Surgery Interest Group and the Asian Pacific American Medical Student Association.
Dr. Yang graduated from Duke University with a B.A. in Chemistry and received his M.D. degree from the Medical College of Virginia. He completed his general surgery residency at the University of Texas Health Science Center at Houston, and finished his cardiothoracic surgery fellowship at the Medical College of Virginia. He also completed a 3 year thoracic surgical oncology research fellowship at the University of Texas M. D. Anderson Cancer Center.
He currently serves on the Postgraduate Affairs, Medical School Admissions, Educational Policy, and Curriculum Reform Committees in the Johns Hopkins School of Medicine. He served on numerous national and international committees for these organizations, and is the Taskforce Chair on the Looking to the Future Residency Scholarships for the Society of Thoracic Surgeons He is Editor of Practical Reviews in Chest Medicine and guest editor/ reviewer for numerous peer review journals. He is co-editor of the book Current Therapy in Thoracic and Cardiovascular Surgery, edited the esophageal surgical section in the 2nd edition of Atlas of Gastrointestinal Surgery with John Cameron, M.D., and series editor-in-chief of The Early Diagnosis of Cancer also editing the book volume of The Early Diagnosis of Lung Cancer. In 2001, he and his lung transplant team were featured in the ABC series 24/7 and is currently also being followed in the sequel to that series focusing in on resident and medical student teaching. This series as well as other experiences are still shown on the Discovery Channel. The extensive work in preparing an esophageal cancer patient for surgery on the BBC and the Discovery Channel.
Dr. Yang's laboratory research interests include using molecular techniques for lung cancer screening and for molecular staging of micrometastasis to predict recurrence following surgical resection. His clinical practice and research covers the breath of general thoracic surgery in pulmonary and esophageal surgery, video-assisted and robotics thoracic surgery, mediastinal and pleural work, lung volume reduction surgery for emphysema, and work in geriatric thoracic surgery.
- Associate Vice Chair for Faculty Development
- The Arthur B. and Patricia B. Modell Professor in Thoracic Surgery
- Professor of Surgery
- Professor of Oncology
- MD; Medicine, Medical College of Virginia School of Medicine (1984)
- University of Texas Health Science Center at Houston / General Surgery (1987)
- University of Texas Health Science Center at Houston / General Surgery (1992)
- The University of Texas MD Anderson Cancer Center (1990)
- Medical College of Virginia School of Medicine / Cardiothoracic Surgery (1994)
- American Board of Thoracic Surgery / Thoracic Surgery (1996)
Research & Publications
Selected PublicationsView all on Pubmed
Brock, M.V.; Hooker, C.M.; Engels, E.A.; Moore, R.D.; Gillison, M.L.; Alberg, A.J.; Keruly, J.C.; Yang, S.C.; Heitmiller, R.F.; Baylin, S.B.; Herman, J.G.; Brahmer, J.R. Delayed diagnosis and elevated mortality in an urban population with HIV and lung cancer: implications for patient care. J Acquir Immune Defic Syndr. 2006 Sep;43(1):47-55.
Gott, V.L.; Patel, N.D.; Yang, S.C.; Baumgartner, W.A. Attracting outstanding students (premedical and medical) to a career in cardiothoracic surgery. Ann Thorac Surg. 2006 Jul;82(1):1-3.
Heath, E.I.; Burtness, B.A.; Kleinberg, L.; Salem, R.R.; Yang, S.C.; Heitmiller, R.F.; Canto, M.I.; Knisely, J.P.; Topazian, M.; Montgomery, E.; Tsottles, N.; Pithavala, Y.; Rohmiller, B.; Collier, M.; Forastiere, A.A. Phase II, parallel-design study of preoperative combined modality therapy and the matrix metalloprotease (mmp) inhibitor prinomastat in patients with esophageal adenocarcinoma. Invest New Drugs. 2006 Mar;24(2):135-140.
Kleinberg, L.; Gibson, M.; Yang, S.; Forastiere, A.A.; Putnam, J.B. Primary Combined Modality Therapy for Esophageal Cancer. Oncology. 2006;20(5):505-511.
Montgomery, E.; Mamelak, A.J.; Gibson, M.; Maitra, A.; Sheikh, S.; Amr, S.S.; Yang, S.; Brock, M.; Forastiere, A.; Zhang, S.; Murphy, K.M.; Berg, K.D. Overexpression of claudin proteins in esophageal adenocarcinoma and its precursor lesions. Appl Immunohistochem Mol Morphol. 2006 Mar;14(1):24-30.
Schachna, L.; Medsger, T.A., Jr.; Dauber, J.H.; Wigley, F.M.; Braunstein, N.A.; White, B.; Steen, V.D.; Conte, J.V.; Yang, S.C.; McCurry, K.R.; Borja, M.C.; Plaskon, D.E.; Orens, J.B.; Gelber, A.C. Lung transplantation in scleroderma compared with idiopathic pulmonary fibrosis and idiopathic pulmonary arterial hypertension. Arthritis Rheum. 2006 Dec;54(12):3954-3961.
Weiss, E.S.; Doty, J.; Brock, M.V.; Halvorson, L.; Yang, S.C. A case of ectopic parathyroid hormone production by a pulmonary neoplasm. J Thorac Cardiovasc Surg. 2006 Apr;131(4):923-924.
Madar, I.; Bencherif, B.; Lever, J.; Heitmiller, R.F.; Yang, S.C.; Brock, M.; Brahmer, J.; Ravert, H.; Dannals, R.; Frost, J.J. Imaging delta- and mu-opioid receptors by PET in lung carcinoma patients. J Nucl Med. 2007 Feb;48(2):207-213.
Brock, M.V.; Hooker, C.M.; Ota-Machida, E.; Han, Y.; Guo, M.; Ames, S.; Glockner, S.; Piantadosi, S.; Gabrielson, E.; Pridham, G.; Pelosky, K.; Belinsky, S.A.; Yang, S.C.; Baylin, S.B.; Herman, J.G. DNA methylation markers and early recurrence in stage I lung cancer. N Engl J Med. 2008 Mar 13;358(11):1118-1128.
Carpenter, A.J.; Yang, S.C.; Uhlig, P.N.; Colson, Y.L. Envisioning simulation in the future of thoracic surgical education. J Thorac Cardiovasc Surg. 2008 Mar;135(3):477-484.
Durr, M.L.; Yang, S.C. Traumatic right paraesophageal hernia after Belsey Mark IV fundoplication. Ann Thorac Surg. 2008 Jan;85(1):321-322
Meguid, R.A.; Brooke, B.S.; Chang, D.C.; Sherwood, J.T.; Brock, M.V.; Yang, S.C. Are surgical outcomes for lung cancer resections improved at teaching hospitals? Ann Thorac Surg. 2008 Mar;85(3):1015-1024; discussion 1024-1015.
Meguid, R.A.; Hooker, C.M.; Taylor, J.T.; Kleinberg, L.R.; Cattaneo, S.M., 2nd; Sussman, M.S.; Yang, S.C.; Heitmiller, R.F.; Forastiere, A.A.; Brock, M.V. Recurrence after neoadjuvant chemoradiation and surgery for esophageal cancer: does the pattern of recurrence differ for patients with complete response and those with partial or no response? J Thorac Cardiovasc Surg. 2009 Dec;138(6):1309-1317.
Meguid, R.A.; Weiss, E.S.; Chang, D.C.; Brock, M.V.; Yang, S.C. The effect of volume on esophageal cancer resections: what constitutes acceptable resection volumes for centers of excellence? J Thorac Cardiovasc Surg. 2009 Jan;137(1):23-29.
Cerchietti, L.C.; Hatzi, K.; Caldas-Lopes, E.; Yang, S.N.; Figueroa, M.E.; Morin, R.D.; Hirst, M.; Mendez, L.; Shaknovich, R.; Cole, P.A.; Bhalla, K.; Gascoyne, R.D.; Marra, M.; Chiosis, G.; Melnick, A. BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy. J Clin Invest. 2010 Nov 1.
Ettinger, D.S.; Akerley, W.; Bepler, G.; Blum, M.G.; Chang, A.; Cheney, R.T.; Chirieac, L.R.; D''Amico, T.A.; Demmy, T.L.; Ganti, A.K.; Govindan, R.; Grannis, F.W., Jr.; Jahan, T.; Jahanzeb, M.; Johnson, D.H.; Kessinger, A.; Komaki, R.; Kong, F.M.; Kris, M.G.; Krug, L.M.; Le, Q.T.; Lennes, I.T.; Martins, R.; O''Malley, J.; Osarogiagbon, R.U.; Otterson, G.A.; Patel, J.D.; Pisters, K.M.; Reckamp, K.; Riely, G.J.; Rohren, E.; Simon, G.R.; Swanson, S.J.; Wood, D.E.; Yang, S.C. Non-small cell lung cancer. J Natl Compr Canc Netw. 2010 Jul;8(7):740-801.
Ettinger, D.S.; Akerley, W.; Bepler, G.; Blum, M.G.; Chang, A.; Cheney, R.T.; Chirieac, L.R.; D''Amico, T.A.; Demmy, T.L.; Govindan, R.; Grannis, F.W., Jr.; Jahan, T.; Johnson, D.H.; Kessinger, A.; Komaki, R.; Kong, F.M.; Kris, M.G.; Krug, L.M.; Le, Q.T.; Lennes, I.T.; Martins, R.; O''Malley, J.; Osarogiagbon, R.U.; Otterson, G.A.; Patel, J.D.; Pisters, K.M.; Reckamp, K.; Riely, G.J.; Rohren, E.; Swanson, S.J.; Wood, D.E.; Yang, S.C. Thymic malignancies. J Natl Compr Canc Netw. 2010 Nov;8(11):1302-1315.
Meguid, R.A.; Hooker, C.M.; Harris, J.; Xu, L.; Westra, W.H.; Sherwood, J.T.; Sussman, M.; Cattaneo, S.M., 2nd; Shin, J.; Cox, S.; Christensen, J.; Prints, Y.; Yuan, N.; Zhang, J.; Yang, S.C.; Brock, M.V. Long-term survival outcomes by smoking status in surgical and nonsurgical patients with non-small cell lung cancer: comparing never smokers and current smokers. Chest. 2010 Sep;138(3):500-509.
Activities & Honors
- Research Scholar, American Association of Thoracic Surgery, 1997
- William F. Rienhoff award for teaching and research, Johns Hopkins, 1996
- Outstanding Alumnus, Medical College of Virginia, 2004
- Program Director research award, Thoracic Surgery Directors Association, 2007
- American Association of Thoracic Surgeons
- American College of Chest Physicians
- American College of Surgeons
- American College of Surgeons
- American College of Surgeons Oncology Group
- Association for Academic Surgeons
- Association for Surgical Education
- International Society of Heart and Lung Transplantation
- Society of Thoracic Surgeons
- Society of University Surgeons