Dr. Diette’s research focuses on identifying factors that cause or provoke asthma. His team focuses on air pollutants (particulate matter, NO2, secondhand smoke) and allergens (including mouse) that are especially problematic in inner-city homes. They are studying the effects of these pollutants and allergens on inflammation and oxidative stress. More recently, they have begun examining how dietary patterns, especially a Western style diet, may increase susceptibility to inhalable pollutants and allergens.
He is currently leading two clinical trials at Johns Hopkins. The first examines the effect of air quality on the adult asthmatic response and the other examines how improving provider-patient communication can reduce asthma disparities.
The effect of air quality on the adult asthmatic response (INHALE)
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Tanner NT, Aggarwal J, Gould MK, Kearney P, Diette G, Vachani A, Fang KC, Silvestri GA. "Management of pulmonary nodules by community pulmonologists: a multicenter observational study." Chest. 2015 Jun 18. doi: 10.1378/chest.15-0630.
Sussan TE, Gajghate S, Chatterjee S, Mandke P, McCormick S, Sudini K, Kumar S, Breysse PN, Diette GB, Sidhaye VK, Biswal S. "Nrf2 reduces allergic asthma in mice through enhanced airway epithelial cytoprotective function." Am J Physiol Lung Cell Mol Physiol. 2015 Jul 1;309(1):L27-36. doi: 10.1152/ajplung.00398.2014.
Jaganath D, Miranda JJ, Gilman RH, Wise RA, Diette GB, Miele CH, Bernabe-Ortiz A, Checkley W; CRONICAS Cohort Study Group. "Prevalence of chronic obstructive pulmonary disease and variation in risk factors across four geographically diverse resource-limited settings in Peru." Respir Res. 2015 Mar 18;16:40. doi: 10.1186/s12931-015-0198-2.
Kolahdooz F, Butler JL, Christiansen K, Diette GB, Breysse PN, Hansel NN, McCormack MC, Sheehy T, Gittelsohn J, Sharma S. "Food and nutrient intake in African American children and adolescents aged 5 to 16 years in Baltimore City." J Am Coll Nutr. 2015 Apr 9:1-12. [Epub ahead of print]
Diette GB, Dalal AA, D'Souza AO, Lunacsek OE, Nagar SP. "Treatment patterns of chronic obstructive pulmonary disease in employed adults in the United States." Int J Chron Obstruct Pulmon Dis. 2015 Feb 24;10:415-22. doi: 10.2147/COPD.S75034. eCollection 2015.
McCormack MC, Belli AJ, Kaji DA, Matsui EC, Brigham EP, Peng RD, Sellers C, Williams DL, Diette GB, Breysse PN, Hansel NN. "Obesity as a susceptibility factor to indoor particulate matter health effects in COPD." Eur Respir J. 2015 May;45(5):1248-57. doi: 10.1183/09031936.00081414. Epub 2015 Jan 8.
Paulin LM, Diette GB, Blanc PD, Putcha N, Eisner MD, Kanner RE, Belli AJ, Christenson S, Tashkin DP, Han M, Barr RG, Hansel NN; SPIROMICS Research Group. "Occupational exposures are associated with worse morbidity in patients with chronic obstructive pulmonary disease." Am J Respir Crit Care Med. 2015 Mar 1;191(5):557-65.
Brigham EP, Kolahdooz F, Hansel N, Breysse PN, Davis M, Sharma S, Matsui EC, Diette G, McCormack MC. "Association between Western diet pattern and adult asthma: a focused review." Ann Allergy Asthma Immunol. 2015 Apr;114(4):273-80. doi: 10.1016/j.anai.2014.11.003. Epub 2014 Dec 15. Review.
Vachani A, Tanner NT, Aggarwal J, Mathews C, Kearney P, Fang KC, Silvestri G, Diette GB. "Factors that influence physician decision making for indeterminate pulmonary nodules." Ann Am Thorac Soc. 2014 Dec;11(10):1586-91.
Kaji DA, Belli AJ, McCormack MC, Matsui EC, Williams DL, Paulin L, Putcha N, Peng RD, Diette GB, Breysse PN, Hansel NN. "Indoor pollutant exposure is associated with heightened respiratory symptoms in atopic compared to non-atopic individuals with COPD." BMC Pulm Med. 2014 Sep 10;14:147.
Paulin LM, Diette GB, Scott M, McCormack MC, Matsui EC, Curtin-Brosnan J, Williams DL, Kidd-Taylor A, Shea M, Breysse PN, Hansel NN. Home interventions are effective at decreasing indoor nitrogen dioxide concentrations. Indoor Air. 2013 Dec 14. doi: 10.1111/ina.12085. [Epub ahead of print] PMID: 24329966
Okelo SO, Riekert KA, Eakin MN, Bilderback AL, Diette GB, Rand CS, Yenokyan G. Pediatrician qualifications and asthma management behaviors and their association with patient race/ethnicity. J Asthma. 2013 Dec 6. [Epub ahead of print] PMID: 24256071
Matsui EC, Hansel NN, Aloe C, Schiltz AM, Peng RD, Rabinovitch N, Ong MJ, Williams DL, Breysse PN, Diette GB, Liu AH. Indoor pollutant exposures modify the effect of airborne endotoxin on asthma in urban children. Am J Respir Crit Care Med. 2013 Nov 15;188(10):1210-5. doi: 10.1164/rccm.201305-0889OC. PMID: 24066676
Okelo SO, Butz AM, Sharma R, Diette GB, Pitts SI, King TM, Linn ST, Reuben M, Chelladurai Y, Robinson KA. Interventions to modify health care provider adherence to asthma guidelines: a systematic review. Pediatrics. 2013 Sep;132(3):517-34. doi: 10.1542/peds.2013-0779. Epub 2013 Aug 26. Review. PMID: 23979092
Ahluwalia SK, Peng RD, Breysse PN, Diette GB, Curtin-Brosnan J, Aloe C, Matsui EC. Mouse allergen is the major allergen of public health relevance in Baltimore City. J Allergy Clin Immunol. 2013 Oct;132(4):830-5.e1-2. doi: 10.1016/j.jaci.2013.05.005. Epub 2013 Jun 26. PMID: 23810154
Okelo SO, Butz AM, Sharma R, Diette GB, Pitts SI, King TM, Linn ST, Reuben M, Chelladurai Y, Robinson KA. Interventions to Modify Health Care Provider Adherence to Asthma Guidelines [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2013 May. PMID: 23805435
McCormack MC, Aloe C, Curtin-Brosnan J, Diette GB, Breysse PN, Matsui EC. Guideline-Recommended Fractional Exhaled Nitric Oxide Is a Poor Predictor of Health-care Use Among Inner-city Children and Adolescents Receiving Usual Asthma Care. Chest. 2013 Sep;144(3):923-9. doi: 10.1378/chest.12-3098. PMID: 23764806
Bose S, Breysse PN, McCormack MC, Hansel NN, Rusher RR, Matsui E, Peng R, Curtin-Brosnan J, Diette GB. Outdoor exposure and vitamin D levels in urban children with asthma. Nutr J. 2013 Jun 12;12(1):81. [Epub ahead of print] PMID: 23758744
Martin WJ 2nd, Glass RI, Araj H, Balbus J, Collins FS, Curtis S, Diette GB, Elwood WN, Falk H, Hibberd PL, Keown SE, Mehta S, Patrick E, Rosenbaum J, Sapkota A, Tolunay HE, Bruce NG. Household air pollution in low- and middle-income countries: health risks and research priorities. PLoS Med. 2013;10(6):e1001455. doi: 10.1371/journal.pmed.1001455. Epub 2013 Jun 4. No abstract available. PMID: 23750119
Jamieson DB, Matsui EC, Belli A, McCormack MC, Peng E, Pierre-Louis S, Curtin-Brosnan J, Breysse PN, Diette GB, Hansel NN. Effects of allergic phenotype on respiratory symptoms and exacerbations in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2013 Jul 15;188(2):187-92. doi: 10.1164/rccm.201211-2103OC. PMID: 23668455