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Constance Lucille Monitto, M.D.
Associate Clinical Director, Pediatric Anesthesiology
Assistant Professor of Anesthesiology and Critical Care Medicine
Expertise: Anesthesiology, Critical Care Medicine
Research Interests: Assessing the impact of epigenetic gene regulation on the development of resistance to chemotherapeutic agents in cancer; Pediatric pain management ...read more
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Dr. Constance L. Monitto is an assistant professor of anesthesiology and critical care medicine at the Johns Hopkins University School of Medicine. Her clinical work focuses on intraoperative anesthetic management of pediatric patients as well as attending on the pediatric acute pain service.
She serves as associate clinical director of pediatric anesthesiology at the Johns Hopkins University School of Medicine.
Dr. Monitto received her undergraduate degree in physics from Princeton University and earned her medical degree from Harvard Medical School. She completed a residency in pediatrics at The Children’s Hospital, Boston, and a residency in anesthesia at Massachusetts General Hospital. She also completed a subspecialty residency in pediatric anesthesia at The Children’s Hospital of Philadelphia (CHOP). After remaining on staff at CHOP for two years, Dr. Monitto joined the Johns Hopkins faculty in 1994.
Dr. Monitto's clinical research interest is pediatric pain management and her basic science research involves assessing the impact of epigenetic gene regulation on the development of resistance to chemotherapeutic agents in cancer.
She is a member of the American Academy of Pediatrics, the American Society of Anesthesiologists, the Society for Pediatric Anesthesia and the International Anesthesia Research Society.
- Associate Clinical Director, Pediatric Anesthesiology
- Assistant Professor of Anesthesiology and Critical Care Medicine
Centers & Institutes
- MD; Medicine, Harvard Medical School (1985)
- Children's Hospital / Pediatrics (1988)
- Massachusetts General Hospital / Anesthesiology (1990)
- Children's Hospital of Philadelphia / Anesthesiology and Critical Care Medicine (1991)
- American Board of Anesthesiology / Anesthesiology (1992)
- American Board of Anesthesiology / Pediatric Anesthesiology (2014)
Research & Publications
Dr. Constance L. Monitto is involved in both clinical and basic science research. Her clinical research is focused on pediatric pain management. She and her coworkers are assessing the impact of low-dose opioid antagonism on opioid-related side effects, such as nausea, vomiting, and pruritis. They also are completing analysis of data regarding current methods of pediatric pain management across the country.
In her basic science studies, Dr. Monitto is assessing the impact of epigenetic gene regulation on the development of resistance to chemotherapeutic agents in cancer. She is identifying genes that are silenced or downregulated in drug-resistant cell lines and comparing those to their drug-sensitive, isogeneic counterparts by microarray assessment of gene expression followed by pharmacologic unmasking of methylated genes using the compound 5-deoxyazacytidine. Candidate genes are further assessed by siRNA gene silencing. Her clinical research involves pediatric pain management.
- Singh D, Gross RM, Monitto C, Heitmiller E, Njoku D. "In-depth analysis of a subset of POCA registrants: impact on strategies for successful resuscitation." Anesthesiology. 2007; 107:A1934.
- Nelson KL, Yaster M, Kost-Byerly S, Monitto C. "Patient controlled analgesia by proxy: results from a national survey." Anesthesiology. 2007;107:A685.
- Nelson KL, Yaster M, Kost-Byerly S, Monitto C. "Pediatric pain management – results of a national survey of pediatric anesthesiologists." Anesthesiology. 2007;107:A688.
- Hoque MO, Soria JC, Woo J, Lee T, Lee J, Jang SJ, Udaphyay S, Trink B, Monitto C, Desmaze C, Mao L. Sidransky D, Moon C. "Aquaporin 1 is overexpressed in lung cancer and stimulates NIH-3T3 cell proliferation and anchorage-independent growth." Am J Pathol. 2006;168(4):1345-1353. doi: 10.2353/ajpath.2006.050596.
- Xiao Y, Monitto CL, Minhas KM, Sidransky D. "Lactoferrin down-regulates G1 cyclin-dependent kinases during growth arrest of head and neck cancer cells." Clin Canc Res. 2004;10(24):8683-8686. doi: 10.1158/1078-0432.CCR-04-098.
Activities & Honors
- Research Day Award, Department of Anesthesiology and Critical Care Medicine, 2009
- American Academy of Pediatrics
- American Society of Anesthesiologists
- International Anesthesia Research Society
- Society for Pediatric Anesthesia
- Guest Reviewer, Anesthesia and Analgesia
- Guest Reviewer, British Journal of Cancer
- Guest Reviewer, Clinical Cancer Research