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Kathryn Rae Wagner, M.D., Ph.D.

Photo of Dr. Kathryn Rae Wagner, M.D., Ph.D.

Professor of Neurology

Female

Expertise: Fabry Disease, Friedreich's Ataxia, Muscular Dystrophies, Myopathy, Myositis, Neurology, Periodic Paralysis

Research Interests: muscle growth and regeneration

Locations

The Johns Hopkins Hospital (Main Entrance)
Appointment Phone: 443-923-9525

1800 Orleans St.
Sheikh Zayed Tower
Baltimore, MD 21287 map

Johns Hopkins Bayview Medical Center
Appointment Phone: 443-923-9525

4940 Eastern Avenue
Baltimore, MD 21224 map

Background

Dr. Kathryn Wagner is the director of the Center for Genetic Muscle Disorders at the Kennedy Krieger Institute and a Professor of Neurology and Neuroscience at the Johns Hopkins School of Medicine.

Dr. Wagner obtained her undergraduate degree from Yale University, graduating summa cum laude with honors in biology. She participated in the NIH-funded medical scientist training program and obtained her medical and doctoral degrees at Johns Hopkins. Her thesis work in the laboratory of Richard Huganir, Ph.D., included the original cloning and characterization of the dystrophin-associated protein, dystrobrevin.

She completed her internship in internal medicine and residency in neurology at Johns Hopkins. She went on to complete a neuromuscular fellowship at Hopkins and a clinical neurogenetics fellowship with Kenneth Fischbeck, M.D., at the National Institutes of Health. With Dr. Fischbeck, she conducted the first clinical trial attempting to suppress nonsense mutations in Duchenne muscular dystrophy patients. In 2000, Dr. Wagner joined the faculty at Johns Hopkins, and in June 2009, joined the Kennedy Krieger Institute to allow her patients with muscular dystrophy to benefit from the institute's historical strengths in rehabilitation and neurogenetics.

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Titles

  • Professor of Neurology
  • Professor of Neuroscience

Departments / Divisions

Education

Degrees

  • M.D., Johns Hopkins University School of Medicine (Maryland) (1994)
  • Ph.D., Johns Hopkins University School of Medicine (Maryland) (1994)

Research & Publications

Research Summary

Dr. Wagner focuses her laboratory and clinical research on developing methods to promote muscle regeneration. A major emphasis has been on modulating myostatin, a potent regulator of muscle growth. Dr. Wagner and her colleagues have shown that myostatin inhibition improves several of the features of the dystrophic mdx mouse model and that loss of myostatin in humans is associated with increased muscle mass. Furthermore, Dr. Wagner’s laboratory has shown that inhibition of myostatin stimulates muscle stem cells, dramatically improving muscle regeneration while reducing fibrosis. Her work, as well as others in the field, has led to development of myostatin inhibitors by several pharmaceutical companies. Dr. Wagner was the principal investigator of a clinical trial of one such inhibitor of myostatin, MYO-029 developed by Wyeth, in adults with muscular dystrophy. Myostatin inhibition with novel pharmacologic agents is a current goal of Dr. Wagner’s research for Duchenne and Facioscapulohumeral muscular dystrophy.

Lab Website: Kathryn Wagner Lab

Clinical Trial Keywords

muscular dystrophy

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