Cornelia Liu Trimble, M.D.

Headshot of Cornelia Liu Trimble
  • Professor of Gynecology and Obstetrics
Female

Expertise

Cervical Cancer, Cervical Dysplasia, Gynecology and Obstetrics, Human Papillomavirus Infections ...read more

Research Interests

Cervical Cancer; HPV; Cancer Vaccines; tumor immunology, tumor microenvironment, intraepithelial neoplasia ...read more

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Insurance Information

Main Phone

Outside of Maryland & Washington D.C.

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International Patients

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Locations

Johns Hopkins Outpatient Center (now called Levi Watkins, Jr., M.D., Outpatient Center)

Appointment Phone: 443-997-0400
601 N. Caroline St.
Baltimore, MD 21287
Johns Hopkins Outpatient Center (now called Levi Watkins, Jr., M.D., Outpatient Center) - Google Maps

Johns Hopkins Medicine - Green Spring Station

Appointment Phone: 443-997-0400
10753 Falls Road
Johns Hopkins Women's Center, Pavilion II, Suite 245
Lutherville, MD 21093
Phone: 443-997-0400 | Fax: 410-367-3312
Johns Hopkins Medicine - Green Spring Station - Google Maps

Background

Dr. Cornelia Trimble is a professor in the Department of Gynecology and Obstetrics. She has joint appointments in the Departments of Gynecology and Obstetrics, Oncology, and Pathology.

Dr. Trimble completed her residency in anatomic pathology at Cornell University Medical Center, followed by a fellowship in gynecologic pathology and a residency in gynecology and obstetrics at The Johns Hopkins Hospital. Her clinical interest and expertise is in developing new ways to intercept cancers — treating pre-invasive, cancer precursor lesions — caused by HPV.

Her work has focused on two nonsurgical strategies: (1) immunotherapy via therapeutic HPV vaccination, and (2) repurposing artesunate, a plant-derived compound used to treat malaria, as a topical treatment administered by the patient herself to treat high-grade, intraepithelial HPV lesions. Her work has shown proof-of-principle, that it is indeed possible to eliminate HPV pre-cancers without surgery, and has been recognized internationally.

Dr. Trimble has dedicated herself to delivering cutting-edge care to girls and women who have a very common problem, caused by a very common virus, HPV. She values respect, integrity, quality and compassion in caring for her patients.

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Titles

  • Professor of Gynecology and Obstetrics
  • Professor of Oncology
  • Professor of Pathology

Departments / Divisions

Centers & Institutes

Education

Degrees

  • MD; Medicine; Vanderbilt University School of Medicine (1988)

Residencies

  • Obstetrics and Gynecology; Johns Hopkins University School of Medicine (1996)
  • Pathology; New York Hospital (1991)

Fellowships

  • Johns Hopkins University School of Medicine (1997)

Board Certifications

  • American Board of Obstetrics and Gynecology (Obstetrics And Gynecology) (2001)
  • American Board of Pathology (Anatomic Pathology) (1993)

Additional Training

  • Anatomic Pathology
  • Obstetrics and Gynecology

Research & Publications

Technology Expertise Keywords

Human papillomavirus (HPV), cervical dysplasia, clinical trials, CIN2/3, immunotherapy, alternative treatments for HPV disease

Clinical Trial Keywords

therapeutic vaccines, HPV, high grade dysplasia, precancerous, alternative HPV treatments, lesion microenvironment

Clinical Trials

J0866 - A Pilot Study of pNGVL4a-CRT/E7(detox) for the treatment of patients with HPV16+ Cervical Intraepithelial Neoplasia 2/3 (CIN2/3)


J1498 - A Phase I Study of Intravaginally Administered Artesunate In Women with High Grade Cervical Intraepithelial Neoplasia (CIN2/3)


J0656 - A Phase I efficacy and safety study of HPV16-specific therapeutic DNA-Vaccinia vaccination in combination with topical imiquimod, in patients with HPV16 high grade cervical dysplasia (CIN2/3)

Selected Publications

Peng, S.; Tomson, T.T.; Trimble, C.; He, L.; Hung, C.F.; Wu, T.C. A combination of DNA vaccines targeting human papillomavirus type 16 E6 and E7 generates potent antitumor effects. Gene Ther. 2006 Feb;13(3):257-265.

Peng, S.; Trimble, C.; He, L.; Tsai, Y.C.; Lin, C.T.; Boyd, D.A.; Pardoll, D.; Hung, C.F.; Wu, T.C. Characterization of HLA-A2-restricted HPV-16 E7-specific CD8(+) T-cell immune responses induced by DNA vaccines in HLA-A2 transgenic mice. Gene Ther. 2006 Jan;13(1):67-77.

Peng, S.; Trimble, C.; Wu, L.; Pardoll, D.; Roden, R.; Hung, C.F.; Wu, T.C. HLA-DQB1*02-restricted HPV-16 E7 peptide-specific CD4+ T-cell immune responses correlate with regression of HPV-16-associated high-grade squamous intraepithelial lesions. Clin Cancer Res. 2007 Apr 15;13(8):2479-2487.

Partridge, E.E.; Abu-Rustum, N.; Campos, S.; Fahey, P.J.; Greer, B.E.; Lele, S.M.; Lieberman, R.W.; Lipscomb, G.H.; Morgan, M.; Nava, M.E.; Reynolds, R.K.; Singh, D.K.; Smith-McCune, K.; Teng, N.; Trimble, C.L.; Valea, F.; Wilczynski, S.; National Comprehensive Cancer, N. Cervical cancer screening. J Natl Compr Canc Netw. 2008 Jan;6(1):58-82.

Peng, S.; Trimble, C.; Alvarez, R.D.; Huh, W.K.; Lin, Z.; Monie, A.; Hung, C.F.; Wu, T.C. Cluster intradermal DNA vaccination rapidly induces E7-specific CD8+ T-cell immune responses leading to therapeutic antitumor effects. Gene Ther. 2008 Aug;15(16):1156-1166.

Trimble, C.L. Human papillomavirus vaccination should be offered to young males: Counterpoint. Cancer Epidemiol Biomarkers Prev. 2008 Apr;17(4):809.
Tseng, C.W.; Hung, C.F.; Alvarez, R.D.; Trimble, C.; Huh, W.K.; Kim, D.; Chuang, C.M.; Lin, C.T.; Tsai, Y.C.; He, L.; Monie, A.; Wu, T.C. Pretreatment with cisplatin enhances E7-specific CD8+ T-Cell-mediated antitumor immunity induced by DNA vaccination. Clin Cancer Res. 2008 May 15;14(10):3185-3192.

Tseng, C.W.; Monie, A.; Trimble, C.; Alvarez, R.D.; Huh, W.K.; Buchsbaum, D.J.; Straughn, J.M., Jr.; Wang, M.C.; Yagita, H.; Hung, C.F.; Wu, T.C. Combination of treatment with death receptor 5-specific antibody with therapeutic HPV DNA vaccination generates enhanced therapeutic anti-tumor effects. Vaccine. 2008 Aug 12;26(34):4314-4319.

Tseng, C.W.; Trimble, C.; Zeng, Q.; Monie, A.; Alvarez, R.D.; Huh, W.K.; Hoory, T.; Wang, M.C.; Hung, C.F.; Wu, T.C. Low-dose radiation enhances therapeutic HPV DNA vaccination in tumor-bearing hosts. Cancer Immunol Immunother. 2008 Sep 25.

Trimble, C.L.; Frazer, I.H. Development of therapeutic HPV vaccines. Lancet Oncol. 2009 Oct;10(10):975-980.

Trimble, C.L.; Peng, S.; Kos, F.; Gravitt, P.; Viscidi, R.; Sugar, E.; Pardoll, D.; Wu, T.C. A phase I trial of a human papillomavirus DNA vaccine for HPV16+ cervical intraepithelial neoplasia 2/3. Clin Cancer Res. 2009 Jan 1;15(1):361-367.

Trimble, C.L.; Peng, S.; Thoburn, C.; Kos, F.; Wu, T.C. Naturally occurring systemic immune responses to HPV antigens do not predict regression of CIN2/3. Cancer Immunol Immunother. 2009 Dec 13.

Tseng, C.W.; Trimble, C.; Zeng, Q.; Monie, A.; Alvarez, R.D.; Huh, W.K.; Hoory, T.; Wang, M.C.; Hung, C.F.; Wu, T.C. Low-dose radiation enhances therapeutic HPV DNA vaccination in tumor-bearing hosts. Cancer Immunol Immunother. 2009 May;58(5):737-748.

Yen, H.R.; Harris, T.J.; Wada, S.; Grosso, J.F.; Getnet, D.; Goldberg, M.V.; Liang, K.L.; Bruno, T.C.; Pyle, K.J.; Chan, S.L.; Anders, R.A.; Trimble, C.L.; Adler, A.J.; Lin, T.Y.; Pardoll, D.M.; Huang, C.T.; Drake, C.G. Tc17 CD8 T cells: functional plasticity and subset diversity. J Immunol. 2009 Dec 1;183(11):7161-7168.

Trimble, C.L.; Clark, R.A.; Thoburn, C.; Hanson, N.C.; Tassello, J.; Frosina, D.; Kos, F.; Teague, J.; Jiang, Y.; Barat, N.C.; Jungbluth, A.A. Human papillomavirus 16-associated cervical intraepithelial neoplasia in humans excludes CD8 T cells from dysplastic epithelium. J Immunol. 2010 Dec 1;185(11):7107-7114.

Trimble, C.L.; Peng, S.; Thoburn, C.; Kos, F.; Wu, T.C. Naturally occurring systemic immune responses to HPV antigens do not predict regression of CIN2/3. Cancer Immunol Immunother. 2010 May;59(5):799-803

Zaino RJ, Trimble CL, Silverberg S, Kauderer J, Curtin J.  Reproducibility of the diagnosis of atypical endometrial hyperplasia (AEH): A Gynecologic Oncology Group (GOG) Study. Cancer 2006; 106(4):804-11.

Trimble CL, Kauderer J, Silverberg S, Curtin J, Lim PC, Burke JJ, Zaino RJ. Concurrent endometrial carcinoma (EC) in women with a biopsy diagnosis of atypical endometrial hyperplasia (AEH): a Gynecologic Oncology Group (GOG) study. Cancer 2006; 106(4):812-9. 

Trimble CL, Peng S, Kos F, Gravitt P, Viscidi R, Sugar E, Pardoll DM, Wu TC. A phase I trial of human papillomavirus (HPV) DNA vaccine for HPV16+ cervical intraepithelial neoplasia 2/3. Clin Cancer Res 2009; 15(1):361-7.

Yen HR, Harris TJ, Wata S, Grosso JF, Getnet D, Goldberg MV, Liang KL, Bruno TC, Pyle KJ, Chan SL, Anders RA, Trimble CL, Adler AJ, Lin TY, Pardoll DM, Huang CT, Drake CG. Tc17 CD8 T cells: functional plasticity and subset diversity. J Immunol 2009; 183, 7161-7168.

Trimble CL, Clark RA, Thoburn C, Hanson NC, Tassello J, Frosina D, Kos F, Teague J, Jiang JE, Barat NC, Jungbluth AA. Human papillomavirus 16-associated cervical intraepithelial neoplasia in humans excludes CD8 T cells from dysplastic epithelium.  J Immunol 2010; 185(11):7107-7114

Chou B, Krill LS, Horton BB, Barat CE, Trimble, CL. Disparities in human papillomavirus vaccine completion among vaccine initiators.  Obstet Gynecol 2011; 118(1):14-20.

Levenback CF, Ali S, Coleman RL, Gold MA, Fowler JM, Judson P, Bell MC, De Geest K, Spirtos N, Potkul RK, Leitao MM, Bakkum-Gamez JN, Rossi EC, Lentz SS, Burke II JJ, Van Le L, Trimble CL. Lymphatic Mapping and Sentinel Lymph Node Biopsy in Women with Squamous Carcinoma of the Vulva: A Gynecologic Oncology Group Study. J Clin Oncol 2012; 30(31):3786-91.

Wallbillich JJ, Rhodes H, Milbourne A, Munsell M, Frumovitz M, Brown J, Trimble CL, Schmeler KM. Vulvar intraepithelial neoplasia (VIN2/3): comparing clinical outcomes and evaluating risk factors for recurrence.  Gynecol Oncol, 2012; 127(2):312-5.

Coleman RL, Ali S, Levenback CF, Gold MA, Fowler JM, Judson PL, Bell MC, De Geest K, Spirtos NM, Potkul RK, Leitao MM Jr, Bakkum-Gamez JN, Rossi EC, Lentz SS, Burke JJ 2nd, Van Le L, Trimble CL.  Is bilateral lymphadenectomy for midline squamous carcinoma of the vulva always necessary?  An analysis from Gynecologic Oncology Group (GOG) 173.  Gynecol Oncol, 2013; 128:155-159.

Maldonado L, Teague JE, Morrow MP, Yotova I, Wu TC, Wang C, Desmarais C, Boyer JD, Tycko B, Robins HS, Clark RA, Trimble CL.  Intramuscular therapeutic vaccination targeting HPV16 induces T cell responses that localize in mucosal lesions. Sci Transl Med 2014; 6,(221):221ra13.

Trimble CL, Method M, Leitao M, Lu K, Ioffee O, Hampton M, Higgins R, Zaino R, Mutter GL.  Management of endometrial precancers. Obstet Gynecol,; 2012 Nov;120(5):1160-1175.

Stanley M, Pinto LA, Trimble C.  Human papillomavirus vaccines – immune responses. Vaccine 2012 Nov 20; Supple5:F83-7. 

 

Trimble CL. HPV Infection-Associated Cancers: Next-Generation Technology for Diagnosis and Treatment. Cancer Immunology at the Crossroads series, Cancer Immunol Res, 2014 Oct;2(10):937-942. 

 

Videos & Media

Recent News Articles and Media Coverage

  • Creating Vaccines to Kick Cancer's Butt, Tedx Talk (12/2015)
  • A Bed Of Mouse Cells Helps Human Cells Thrive In The Lab, NPR (01/2015)
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