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Serena M. Bagnasco, M.D.

Photo of Dr. Serena M. Bagnasco, M.D.

Director, Renal Biopsy Service, The Johns Hopkins Hospital

Associate Professor of Pathology

Female

Languages: English, Italian

Expertise: Pathology, Pathology and Laboratory Medicine, Renal Pathology, Transplant Pathology

Research Interests: Kidney molecular physiology and pathology

Locations

The Johns Hopkins Hospital

600 N. Wolfe Street
Department of Pathology
Baltimore, MD 21287 map

Background

Dr. Serena Bagnasco is an associate professor of pathology at the Johns Hopkins University School of Medicine. Her areas of clinical expertise include pathology and transplant pathology. Dr. Bagnasco serves as director of the Hopkins Renal Pathology Service.

Dr. Bagnasco obtained her M.D. degree from the University of Genova in Italy, and spent several years in the Laboratory of Kidney and Electrolyte Metabolism NIH/NHLBI for her post-doctoral training in kidney physiology. She completed a residency in anatomic pathology at Northwestern University in Chicago, and a clinical fellowship in renal pathology at Johns Hopkins.

Her research interests are in the field of renal physiology and pathophysiology. She has studied how renal cells adapt to the environment of the kidney medulla, characterized by high concentration of salt and urea. More recently she has focused on the pathology of renal transplant, and the use of digital pathology in the analysis of kidney biopsies.

Dr. Bagnasco is on the editorial board of several peer reviewed journal including  The American Journal of Physiology, is Academic Editor for PlosOne. Dr. Bagnasco has authored more than 60 articles in scientific journals.

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Titles

  • Director, Renal Biopsy Service, The Johns Hopkins Hospital
  • Associate Professor of Pathology

Departments / Divisions

Education

Degrees

  • MD, Universita' Degli Studi Di Genova (1979)

Residencies

  • Northwestern University Feinberg School of Medicine / Anatomic Pathology (1990)

Fellowships

  • Johns Hopkins University School of Medicine (1993)

Board Certifications

  • American Board of Pathology / Anatomic Pathology (1990)

Research & Publications

Research Summary

Dr. Bagnasco's research interests are in the field of renal physiology / pathophysiology, and pathology.

She has studied the mechanisms of adaptation of renal cells to the environment of the kidney medulla, characterized by high concentration of salt and urea.

She and her team have defined the genomic organization of the gene that encodes the major renal urea transporters, which are essential for the process of urine concentration in the mammalian kidney. They are currently studying the pathways regulating expression and function of these transporters in the kidney and at extrarenal sites.

She is involved in collaborative studies and has published several articles on the pathology of transplanted kidney.

Selected Publications

View all on Pubmed

Nakayama Y, Peng T, Sands JM, Bagnasco SM. The TonE/TonEBP pathway mediates tonicity-responsive regulation of UT-A urea transporter expression. Journal of Biological Chemistry. 2000;275:38275-38280.

Pisitkun T, Gandolfo MT, Knepper M, Bagnasco SM. Application of system biology principles to protein biomarker discovery: urinary exosomal proteome in renal transplantation. Proteomics Clin. Appl. 2012;6(5-6):268-78.

Bagnasco SM, Zachary AA, Racusen LC, Arend LJ, Carter-Monroe N, Alachkar N, Nazarian SM, Lonze BE, Montgomery RA, Kraus ES. Time Course of Pathologic Changes in Kidney Allografts of Positive Crossmatch HLA-Incompatible Transplant Recipients. Transplantation. 2014; 97:440-445.

Mariani LH, Martini S, Barisoni L, Canetta PA, Troost JP, Hodgin JB, Palmer M, Rosenberg AZ, Lemley KV, Chien HP, Zee J, Smith A, Appel GB, Trachtman H, Hewitt SM, Kretzler M, Bagnasco SM: Interstitial fibrosis scored on whole slide digital imaging of kidney biopsies is a predictor of outcome in proteinuric glomerulopathies. Nephrol Dial Transplant. 2018, 33:310-318

Haas M, Loupy A, Lefaucheur C, Roufosse C, Glotz D, Seron D, Nankivell BJ, Halloran PF, Colvin RB, Akalin E, Alachkar N, Bagnasco S, Bouatou Y, Becker JU, Cornell LD, van Huyen JPD, Gibson IW, Kraus ES, Mannon RB, Naesens M, Nickeleit V, Nickerson P, Segev DL, Singh HK, Stegall M, Randhawa P, Racusen L, Solez K, Mengel M. The Banff 2017 kidney meeting report: revised diagnostic criteria for chronic active T cell-mediated rejection, antibody-mediated rejection, and prospects for integrative endpoints for next-generation clinical trials. Am J Transplant. 2018;18:293-307

Contact for Research Inquiries

Johns Hopkins School of Medicine
Pathology Building, Room 711
600 North Wolfe Street
Baltimore, MD 21287 map

Activities & Honors

Professional Activities

  • Editorial Board, The American Journal of Physiology - Renal
  • Editorial Board, Clinical Transplantation
  • Academic Editor, PlosOne
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