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Antonio Carlos Wolff, M.D.

Photo of Dr. Antonio Carlos Wolff, M.D.
  • Professor of Oncology
Male

Languages: English, French, Portuguese, Spanish

Expertise

Breast Cancer, Cancer Survivorship, Clinical Practice Guidelines, Medical Oncology, New Therapies in Breast Cancer, Quality Care, Quality Measures, Risk Assessment and Early Detection ...read more

Research Interests

Breast Cancer

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Insurance Information

Maryland

410-955-8964

Outside of Maryland

410-464-6641
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International Patients

+1-410-502-7683
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Locations

Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

Appointment Phone: 410-955-8964
401 N. Broadway
Harry and Jeanette Weinberg Building
Baltimore, MD 21231 map
Phone: 410-614-4192

Johns Hopkins Medicine - Green Spring Station

Appointment Phone: 410-955-8964
10753 Falls Road
Johns Hopkins Kimmel Cancer Center, Pavilion II Suite 415
Lutherville, MD 21093 map
Phone: 410-583-2970

Background

Dr. Antonio Wolff is a Professor of Oncology at Johns Hopkins University (JHU) and Director, Breast Cancer Trials in the Women’s Malignancies Program at the Johns Hopkins Kimmel Comprehensive Cancer Center (Baltimore, MD, USA). He received his medical degree at the Universidade Federal do Rio de Janeiro in Brazil and trained in medical oncology at Johns Hopkins. He is an Associate Editor of the Journal of Clinical Oncology, Chair of the ECOG-ACRIN Breast Cancer Committee, and Chief Operating Officer for the Translational Breast Cancer Research Consortium (TBCRC). He is a Fellow of the American Society of Clinical Oncology (FASCO) and past Chair of its Clinical Practice Guidelines Committee. His research interests include new treatment strategies, the development and implementation of prognostic and predictive biomarkers (tissue, blood, and imaging) in clinical practice, and on how to improve the survivorship experience of breast cancer patients and their caregivers. He is a Susan G. Komen Scholar, recipient of a Cancer Clinical Investigator Team Leadership Award from the US National Cancer Institute, and was recognized in 2017 by Clarivate Analytics (Thomson Reuters) as one of the world’s most highly cited researchers (top 1% in clinical medicine). He maintains an active clinical practice dedicated to the care of patients with breast cancer and was inducted in 2018 as a member of the JHU Miller Coulson Academy of Clinical Excellence. In 2018, Dr. Wolff was recognized as one of 125 Living the Hopkins Mission Honorees, who were selected for their outstanding dedication to the institution’s core values of excellence and discovery, leadership and integrity, diversity and inclusion, and respect and collegiality, as part of the 125th anniversary celebration of the JHU School of Medicine.

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Titles

  • Professor of Oncology

Departments / Divisions

Centers & Institutes

Education

Degrees

  • MD, Faculdade de Medicina da Universidade Federal do Rio de Janeiro (1986)

Residencies

  • MedStar Good Samaritan Hospital / Internal Medicine (1990)
  • The Mount Sinai Hospital / Internal Medicine (1991)

Fellowships

  • Washington University School of Medicine in St Louis / Hematology and Oncology (1992)
  • Johns Hopkins University School of Medicine / Medical Oncology (1995)

Board Certifications

  • American Board of Internal Medicine / Medical Oncology (1995)

Research & Publications

Clinical Trial Keywords

breast cancer, biomarkers, survivorship

Selected Publications

Carlson, R.W.; Brown, E.; Burstein, H.J.; Gradishar, W.J.; Hudis, C.A.; Loprinzi, C.; Mamounas, E.P.; Perez, E.A.; Pritchard, K.; Ravdin, P.; Recht, A.; Somlo, G.; Theriault, R.L.; Winer, E.P.; Wolff, A.C. NCCN Task Force Report: Adjuvant Therapy for Breast Cancer. J Natl Compr Canc Netw. 2006 Mar;4 Suppl 1:S1-26.

Carlson, R.W.; Moench, S.J.; Hammond, M.E.; Perez, E
.A.; Burstein, H.J.; Allred, D.C.; Vogel, C.L.; Goldstein, L.J.; Somlo, G.; Gradishar, W.J.; Hudis, C.A.; Jahanzeb, M.; Stark, A.; Wolff, A.C.; Press, M.F.; Winer, E.P.; Paik, S.; Ljung, B.M. HER2 testing in breast cancer: NCCN Task Force report and recommendations. J Natl Compr Canc Netw. 2006 Jul;4 Suppl 3:S1-22; quiz S23-24.

Khatcheressian, J.L.; Wolff, A.C.; Smith, T.J.; Grunfeld, E.; Muss, H.B.; Vogel, V.G.; Halberg, F.; Somerfield, M.R.; Davidson, N.E. American Society of Clinical Oncology 2006 update of the breast cancer follow-up and management guidelines in the adjuvant setting. J Clin Oncol. 2006 Nov 1;24(31):5091-5097.

Wolff, A.C.; Davidson, N.E. Still waiting after 110 years: the optimal use of ovarian ablation as adjuvant therapy for breast cancer. J Clin Oncol. 2006 Nov 1;24(31):4949-4951.

Wolff, A.C.; Jones, R.J.; Davidson, N.E.; Jeter, S.C.; Stearns, V. Myeloid toxicity in breast cancer patients receiving adjuvant chemotherapy with pegfilgrastim support. J Clin Oncol. 2006 May 20;24(15):2392-2394; author reply 2394-2395.

Briest, S.; Wolff, A.C. Insights on adjuvant endocrine therapy for premenopausal and postmenopausal breast cancer. Expert review of anticancer therapy. 2007 Sep;7(9):1243-1253.

Carlson, R.W.; Anderson, B.O.; Burstein, H.J.; Carter, W.B.; Edge, S.B.; Farrar, W.B.; Goldstein, L.J.; Gradishar, W.J.; Hayes, D.F.; Hudis, C.A.; Jahanzeb, M.; Ljung, B.M.; Kiel, K.; Marks, L.B.; McCormick, B.; Nabell, L.M.; Pierce, L.J.; Reed, E.C.; Silver, S.M.; Smith, M.L.; Somlo, G.; Theriault, R.L.; Ward, J.H.; Winer, E.P.; Wolff, A.C. Invasive breast cancer. J Natl Compr Canc Netw. 2007 Mar;5(3):246-312.

Cianfrocca, M.; Wolff, A.C. Optimizing endocrine therapy for premenopausal and postmenopausal women with breast cancer. Oncology (Williston Park). 2007 Jan;21(1):63-69; discussion 69, 72, 75 passim.

Messersmith, W.A.; Rudek, M.A.; Baker, S.D.; Zhao, M.; Collins, C.; Colevas, A.D.; Donehower, R.C.; Carducci, M.A.; Wolff, A.C. Phase I study of continuous weekly dosing of dimethylamino benzoylphenylurea (BPU) in patients with solid tumours. Eur J Cancer. 2007 Jan;43(1):78-86.

Moore, H.C.; Green, S.J.; Gralow, J.R.; Bearman, S.I.; Lew, D.; Barlow, W.E.; Hudis, C.; Wolff, A.C.; Ingle, J.N.; Chew, H.K.; Elias, A.D.; Livingston, R.B.; Martino, S. Intensive dose-dense compared with high-dose adjuvant chemotherapy for high-risk operable breast cancer: Southwest Oncology Group/Intergroup study 9623. J Clin Oncol. 2007 May 1;25(13):1677-1682.

Ouwerkerk, R.; Jacobs, M.A.; Macura, K.J.; Wolff, A.C.; Stearns, V.; Mezban, S.D.; Khouri, N.F.; Bluemke, D.A.; Bottomley, P.A. Elevated tissue sodium concentration in malignant breast lesions detected with non-invasive 23Na MRI. Breast Cancer Res Treat. 2007 Dec;106(2):151-160.

Tan, S.H.; Wolff, A.C. Luteinizing hormone-releasing hormone agonists in premenopausal hormone receptor-positive breast cancer. Clin Breast Cancer. 2007 Feb;7(6):455-464.

Wolff, A.C.; Hammond, M.E.; Schwartz, J.N.; Hagerty, K.L.; Allred, D.C.; Cote, R.J.; Dowsett, M.; Fitzgibbons, P.L.; Hanna, W.M.; Langer, A.; McShane, L.M.; Paik, S.; Pegram, M.D.; Perez, E.A.; Press, M.F.; Rhodes, A.; Sturgeon, C.; Taube, S.E.; Tubbs, R.; Vance, G.H.; van de Vijver, M.; Wheeler, T.M.; Hayes, D.F. American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. J Clin Oncol. 2007 Jan 1;25(1):118-145.

Barone, B.B.; Yeh, H.C.; Snyder, C.F.; Peairs, K.S.; Stein, K.B.; Derr, R.L.; Wolff, A.C.; Brancati, F.L. Long-term all-cause mortality in cancer patients with preexisting diabetes mellitus: a systematic review and meta-analysis. JAMA. 2008 Dec 17;300(23):2754-2764.

Burstein, H.J.; Elias, A.D.; Rugo, H.S.; Cobleigh, M.A.; Wolff, A.C.; Eisenberg, P.D.; Lehman, M.; Adams, B.J.; Bello, C.L.; DePrimo, S.E.; Baum, C.M.; Miller, K.D. Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane. J Clin Oncol. 2008 Apr 10;26(11):1810-1816.
Higgins, M.J.; Wolff, A.C. Therapeutic options in the management of metastatic breast cancer. Oncology (Williston Park). 2008 May;22(6):614-623; discussion 623, 627-619.

Marchionni, L.; Wilson, R.F.; Wolff, A.C.; Marinopoulos, S.; Parmigiani, G.; Bass, E.B.; Goodman, S.N. Systematic review: gene expression profiling assays in early-stage breast cancer. Ann Intern Med. 2008 Mar 4;148(5):358-369.
Snyder, C.F.; Garrett-Mayer, E.; Brahmer, J.R.; Carducci, M.A.; Pili, R.; Stearns, V.; Wolff, A.C.; Dy, S.M.; Wu, A.W. Symptoms, supportive care needs, and function in cancer patients: how are they related? Qual Life Res. 2008 Jun;17(5):665-677.

Sparano, J.A.; Wang, M.; Martino, S.; Jones, V.; Perez, E.A.; Saphner, T.; Wolff, A.C.; Sledge, G.W., Jr.; Wood, W.C.; Davidson, N.E. Weekly paclitaxel in the adjuvant treatment of breast cancer. N Engl J Med. 2008 Apr 17;358(16):1663-1671.

Tan, S.H.; Wolff, A.C. The role of ovarian ablation in the adjuvant therapy of breast cancer. Curr Oncol Rep. 2008 Jan;10(1):27-37.

Wolff, A.C.; Berry, D.; Carey, L.A.; Colleoni, M.; Dowsett, M.; Ellis, M.; Garber, J.E.; Mankoff, D.; Paik, S.; Pusztai, L.; Smith, M.L.; Zujewski, J. Research issues affecting preoperative systemic therapy for operable breast cancer. J Clin Oncol. 2008 Feb 10;26(5):806-813.

Allred, D.C.; Carlson, R.W.; Berry, D.A.; Burstein, H.J.; Edge, S.B.; Goldstein, L.J.; Gown, A.; Hammond, M.E.; Iglehart, J.D.; Moench, S.; Pierce, L.J.; Ravdin, P.; Schnitt, S.J.; Wolff, A.C. NCCN Task Force Report: Estrogen Receptor and Progesterone Receptor Testing in Breast Cancer by Immunohistochemistry. J Natl Compr Canc Netw. 2009 Sep;7 Suppl 6:S1-S21; quiz S22-23.

Baker, S.D.; Verweij, J.; Cusatis, G.A.; van Schaik, R.H.; Marsh, S.; Orwick, S.J.; Franke, R.M.; Hu, S.; Schuetz, E.G.; Lamba, V.; Messersmith, W.A.; Wolff, A.C.; Carducci, M.A.; Sparreboom, A. Pharmacogenetic pathway analysis of docetaxel elimination. Clin Pharmacol Ther. 2009 Feb;85(2):155-163.

Balmanoukian, A.; Zhang, Z.; Jeter, S.; Slater, S.; Armstrong, D.K.; Emens, L.A.; Fetting, J.H.; Wolff, A.C.; Davidson, N.E.; Jacobs, L.; Lange, J.; Tsangaris, T.N.; Zellars, R.; Gabrielson, E.; Stearns, V. African American women who receive primary anthracycline- and taxane-based chemotherapy for triple-negative breast cancer suffer worse outcomes compared with white women. J Clin Oncol. 2009 Aug 1;27(22):e35-37; author reply e38-39.

Carlson, R.W.; Allred, D.C.; Anderson, B.O.; Burstein, H.J.; Carter, W.B.; Edge, S.B.; Erban, J.K.; Farrar, W.B.; Goldstein, L.J.; Gradishar, W.J.; Hayes, D.F.; Hudis, C.A.; Jahanzeb, M.; Kiel, K.; Ljung, B.M.; Marcom, P.K.; Mayer, I.A.; McCormick, B.; Nabell, L.M.; Pierce, L.J.; Reed, E.C.; Smith, M.L.; Somlo, G.; Theriault, R.L.; Topham, N.S.; Ward, J.H.; Winer, E.P.; Wolff, A.C. Breast cancer. Clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2009 Feb;7(2):122-192.

Connolly, R.; Wolff, A.C. Pregnancy and fertility with breast cancer: what are the options? Oncology (Williston Park). 2009 May;23(6):478, 481.

Emens, L.A.; Asquith, J.M.; Leatherman, J.M.; Kobrin, B.J.; Petrik, S.; Laiko, M.; Levi, J.; Daphtary, M.M.; Biedrzycki, B.; Wolff, A.C.; Stearns, V.; Disis, M.L.; Ye, X.; Piantadosi, S.; Fetting, J.H.; Davidson, N.E.; Jaffee, E.M. Timed sequential treatment with cyclophosphamide, doxorubicin, and an allogeneic granulocyte-macrophage colony-stimulating factor-secreting breast tumor vaccine: a chemotherapy dose-ranging factorial study of safety and immune activation. J Clin Oncol. 2009 Dec 10;27(35):5911-5918.

Kantsiper, M.; McDonald, E.L.; Geller, G.; Shockney, L.; Snyder, C.; Wolff, A.C. Transitioning to breast cancer survivorship: perspectives of patients, cancer specialists, and primary care providers. J Gen Intern Med. 2009 Nov;24 Suppl 2:S459-466.

Muss, H.B.; Berry, D.A.; Cirrincione, C.T.; Theodoulou, M.; Mauer, A.M.; Kornblith, A.B.; Partridge, A.H.; Dressler, L.G.; Cohen, H.J.; Becker, H.P.; Kartcheske, P.A.; Wheeler, J.D.; Perez, E.A.; Wolff, A.C.; Gralow, J.R.; Burstein, H.J.; Mahmood, A.A.; Magrinat, G.; Parker, B.A.; Hart, R.D.; Grenier, D.; Norton, L.; Hudis, C.A.; Winer, E.P. Adjuvant chemotherapy in older women with early-stage breast cancer. N Engl J Med. 2009 May 14;360(20):2055-2065.

Partridge, A.H.; Wolff, A.C.; Marcom, P.K.; Kaufman, P.A.; Zhang, L.; Gelman, R.; Moore, C.; Lake, D.; Fleming, G.F.; Rugo, H.S.; Atkins, J.; Sampson, E.; Collyar, D.; Winer, E.P. The impact of sharing results of a randomized breast cancer clinical trial with study participants. Breast Cancer Res Treat. 2009 May;115(1):123-129.

Snyder, C.F.; Frick, K.D.; Kantsiper, M.E.; Peairs, K.S.; Herbert, R.J.; Blackford, A.L.; Wolff, A.C.; Earle, C.C. Prevention, screening, and surveillance care for breast cancer survivors compared with controls: changes from 1998 to 2002. J Clin Oncol. 2009 Mar 1;27(7):1054-1061.
Snyder, C.F.; Frick, K.D.; Peairs, K.S.; Kantsiper, M.E.; Herbert, R.J.; Blackford, A.L.; Wolff, A.C.; Earle, C.C. Comparing care for breast cancer survivors to non-cancer controls: a five-year longitudinal study. J Gen Intern Med. 2009 Apr;24(4):469-474.

Snyder, C.F.; Garrett-Mayer, E.; Blackford, A.L.; Brahmer, J.R.; Carducci, M.A.; Pili, R.; Stearns, V.; Wolff, A.C.; Dy, S.M.; Wu, A.W. Concordance of cancer patients'' function, symptoms, and supportive care needs. Qual Life Res. 2009 Oct;18(8):991-998.

Stein, K.B.; Snyder, C.F.; Barone, B.B.; Yeh, H.C.; Peairs, K.S.; Derr, R.L.; Wolff, A.C.; Brancati, F.L. Colorectal Cancer Outcomes, Recurrence, and Complications in Persons With and Without Diabetes Mellitus: A Systematic Review and Meta-Analysis. Dig Dis Sci. 2009 Sep 3.
Zellars, R.C.; Stearns, V.; Frassica, D.; Asrari, F.; Tsangaris, T.; Myers, L.; DiPasquale, S.; Lange, J.R.; Jacobs, L.K.; Emens, L.A.; Armstrong, D.K.; Fetting, J.H.; Garrett-Mayer, E.; Davidson, N.E.; Wolff, A.C. Feasibility trial of partial breast irradiation with concurrent dose-dense doxorubicin and cyclophosphamide in early-stage breast cancer. J Clin Oncol. 2009 Jun 10;27(17):2816-2822.

Barone, B.B.; Yeh, H.C.; Snyder, C.F.; Peairs, K.S.; Stein, K.B.; Derr, R.L.; Wolff, A.C.; Brancati, F.L. Postoperative mortality in cancer patients with preexisting diabetes: systematic review and meta-analysis. Diabetes Care. 2010 Apr;33(4):931-939.

Chavez-Macgregor, M.; Litton, J.; Chen, H.; Giordano, S.H.; Hudis, C.A.; Wolff, A.C.; Valero, V.; Hortobagyi, G.N.; Bondy, M.L.; Gonzalez-Angulo, A.M. Pathologic complete response in breast cancer patients receiving anthracycline- and taxane-based neoadjuvant chemotherapy: evaluating the effect of race/ethnicity. Cancer. 2010 Sep 1;116(17):4168-4177.

Chumsri, S.; Jeter, S.; Jacobs, L.K.; Nassar, H.; Armstrong, D.K.; Emens, L.A.; Fetting, J.H.; Lange, J.R.; Riley, C.; Tsangaris, T.N.; Wolff, A.C.; Zellars, R.; Zhang, Z.; Stearns, V. Pathologic complete response to preoperative sequential doxorubicin/cyclophosphamide and single-agent taxane with or without trastuzumab in stage II/III HER2-positive breast cancer. Clin Breast Cancer. 2010 Feb;10(1):40-45.

Hammond, M.E.; Hayes, D.F.; Dowsett, M.; Allred, D.C.; Hagerty, K.L.; Badve, S.; Fitzgibbons, P.L.; Francis, G.; Goldstein, N.S.; Hayes, M.; Hicks, D.G.; Lester, S.; Love, R.; Mangu, P.B.; McShane, L.; Miller, K.; Osborne, C.K.; Paik, S.; Perlmutter, J.; Rhodes, A.; Sasano, H.; Schwartz, J.N.; Sweep, F.C.; Taube, S.; Torlakovic, E.E.; Valenstein, P.; Viale, G.; Visscher, D.; Wheeler, T.; Williams, R.B.; Wittliff, J.L.; Wolff, A.C. American Society of Clinical Oncology/College Of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer. J Clin Oncol. 2010 Jun 1;28(16):2784-2795.

Hammond, M.E.; Hayes, D.F.; Wolff, A.C.; Mangu, P.B.; Temin, S. American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Immunohistochemical Testing of Estrogen and Progesterone Receptors in Breast Cancer. J Oncol Pract. 2010 Jul;6(4):195-197.

Jacobs, M.A.; Stearns, V.; Wolff, A.C.; Macura, K.; Argani, P.; Khouri, N.; Tsangaris, T.; Barker, P.B.; Davidson, N.E.; Bhujwalla, Z.M.; Bluemke, D.A.; Ouwerkerk, R. Multiparametric magnetic resonance imaging, spectroscopy and multinuclear ((2)(3)Na) imaging monitoring of preoperative chemotherapy for locally advanced breast cancer. Acad Radiol. 2010 Dec;17(12):1477-1485.

Partridge, A.H.; Archer, L.; Kornblith, A.B.; Gralow, J.; Grenier, D.; Perez, E.; Wolff, A.C.; Wang, X.; Kastrissios, H.; Berry, D.; Hudis, C.; Winer, E.; Muss, H. Adherence and persistence with oral adjuvant chemotherapy in older women with early-stage breast cancer in CALGB 49907: adherence companion study 60104. J Clin Oncol. 2010 May 10;28(14):2418-2422.

Snyder, C.F.; Blackford, A.L.; Brahmer, J.R.; Carducci, M.A.; Pili, R.; Stearns, V.; Wolff, A.C.; Dy, S.M.; Wu, A.W. Needs assessments can identify scores on HRQOL questionnaires that represent problems for patients: an illustration with the Supportive Care Needs Survey and the QLQ-C30. Qual Life Res. 2010 Aug;19(6):837-845.

Snyder, C.F.; Stein, K.B.; Barone, B.B.; Peairs, K.S.; Yeh, H.C.; Derr, R.L.; Wolff, A.C.; Carducci, M.A.; Brancati, F.L. Does pre-existing diabetes affect prostate cancer prognosis? A systematic review. Prostate Cancer Prostatic Dis. 2010 Mar;13(1):58-64.

Stein, K.B.; Snyder, C.F.; Barone, B.B.; Yeh, H.C.; Peairs, K.S.; Derr, R.L.; Wolff, A.C.; Brancati, F.L. Colorectal cancer outcomes, recurrence, and complications in persons with and without diabetes mellitus: a systematic review and meta-analysis. Dig Dis Sci. 2010 Jul;55(7):1839-1851.

Peairs, K.S.; Barone, B.B.; Snyder, C.F.; Yeh, H.C.; Stein, K.B.; Derr, R.L.; Brancati, F.L.; Wolff, A.C. Diabetes mellitus and breast cancer outcomes: a systematic review and meta-analysis. J Clin Oncol. 2011 Jan 1;29(1):40-46.

Activities & Honors

Memberships

  • American Association of Cancer Research
  • American Society of Clinical Oncology
  • European Society of Medical Oncology

Professional Activities

  • Associate Editor for Breast Cancer, The Journal of Clinical Oncology, 2012
  • Vice-Chair, ECOG-ACRIN Breast Cancer Committee

Videos & Media

The Impact of Breast Cancer Treatment on Your Long-Term Health

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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