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Anne Margaret Murphy, M.D.
Vice Chair for Basic and Translational Research, Department of Pediatrics
Professor of Pediatrics
Expertise: Cardiology, Hypertrophic Cardiomyopathy, Inherited Heart Diseases, Pediatric Cardiology, Pediatric Congenital Heart Disease
Research Interests: Long-term management of children; Adolescents and young adults with congenital heart defects; Cardiovascular genetics; Hypertrophic cardiomyopathy; Molecular biology of cardiac muscle ...read more
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Dr. Anne Murphy is a Professor of Pediatrics at the Johns Hopkins University School of Medicine. Her areas of clinical expertise include pediatric congenital heart disease, hypertrophic cardiomyopathy, inherited heart diseases and general pediatric cardiology. She participates in the HCMNet a network that conducts studies and clinical trials in hypertrophic cardiomyopathy.
Dr. Murphy also serves as the Vice Chair for Basic and Translational Research for the Department of Pediatrics.
She earned her M.D. from Johns Hopkins University School of Medicine and completed her residency at The Johns Hopkins Hospital. She performed a fellowship at Cincinnati Children’s Hospital. She was an attending pediatric cardiologist at St. Louis Children's Hospital prior to her appointment at Johns Hopkins.
Dr. Murphy maintains a clinical practice as well as a research laboratory. Her laboratory has received grants from the American Heart Association, the National Institutes of Health and the Children's Cardiomyopathy Foundation. She has received the Rowe Award for Cardiology Research from the Society for Pediatric Research and the Meritorious Achievement Award from the American Heart Association Council on Cardiovascular Disease in the Young. Her research on the molecular basis of myocardial stunning was named one of the top 10 research achievements for 1999 by the American Heart Association.
Dr. Murphy is a fellow of the American College of Cardiology and a member of the Society for Pediatric Research.
- Vice Chair for Basic and Translational Research, Department of Pediatrics
- Professor of Pediatrics
- MD, Johns Hopkins University School of Medicine (1981)
- Johns Hopkins University School of Medicine / Pediatrics (1984)
- Cincinnati Childrens Hospital Medical Center / Pediatric Cardiology (1988)
- American Board of Pediatrics / Pediatrics (1986)
Research & Publications
The Murphy lab focuses on the biology of the cardiac sarcomere-the molecular motor of the heart. We study how the proteins of the sarcomere are modified in diseases such as hypertrophic and dilated cardiomyopathy. This provides mechanistic understanding of the contribution of sarcomere dysfunction to disease and provides opportunities to intervene on these serious heart diseases.
Mahle WT, Murphy AM, Li JS, Law YM, Newburger JW, Daniels SR, Bernstein D, Marino BS, Ross RD. "Task Force 8: Pediatric Cardiology Fellowship Training in Research and Scholarly Activity." J Am Coll Cardiol. 2015 Mar 9.
Wijnker PJ, Li Y, Zhang P, Foster DB, Remedios CD, Van Eyk JE, Stienen GJ, Murphy AM, van der Velden J. "A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis." J Mol Cell Cardiol. 2015 Mar 11;82:93-103.
Ross RD, Brook M, Feinstein JA, Koenig P, Lang P, Spicer R, Vincent JA, Lewis AB, Martin GR, Bartz PJ, Fischbach PS, Fulton DR, Matherne GP, Reinking B, Srivastava S, Printz B, Geva T, Shirali GS, Weinberg P, Wong PC, Armsby LB, Vincent RN, Foerster SR, Holzer RJ, Moore JW, Marshall AC, Latson L, Dubin AM, Walsh EP, Franklin W, Kanter RJ, Saul JP, Shah MJ, Van Hare GF, Feltes TF, Roth SJ, Almodovar MC, Andropoulos DB, Bohn DJ, Costello JM, Gajarski RJ, Mott AR, Stout K, Valente AM, Cook S, Gurvitz M, Saidi A, Webber SA, Hsu DT, Ivy DD, Kulik TJ, Pahl E, Rosenthal DN, Morrow R, Mahle WT, Murphy AM, Li JS, Law YM, Newburger JW, Daniels SR, Bernstein D, Marino BS. "2015 SPCTPD/ACC/AAP/AHA Training Guidelines for Pediatric Cardiology Fellowship Programs (Revision of the 2005 Training Guidelines for Pediatric Cardiology Fellowship Programs)." Circulation. 2015 Mar 13.
Mahle WT, Murphy AM, Li JS, Law YM, Newburger JW, Daniels SR, Bernstein D, Marino BS, Ross RD. "Task Force 8: Pediatric Cardiology Fellowship Training in Research and Scholarly Activity." Circulation. 2015 Mar 13
Westenbrink BD, Ling H, Divakaruni AS, Gray CB, Zambon AC, Dalton ND, Peterson KL, Gu Y, Matkovich SJ, Murphy AN, Miyamoto S, Dorn GW 2nd, Heller Brown J. "Mitochondrial reprogramming induced by CaMKIIδ mediates hypertrophy decompensation."Circ Res. 2015 Feb 27;116(5):e28-39.
Activities & Honors
- Rowe Award for Cardiology Research, Society for Pediatric Research
- Clinician-Scientist Award, American Heart Association
- Meritorious Achievement Award, American Heart Association Council on Cardiovascular Disease in the Young, 2016
- Fellow American College of Cardiology
- Society for Pediatric Research