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Ross C Donehower, M.D.

Photo of Dr. Ross C Donehower, M.D.
  • Director, Medical Oncology/Hematogy Fellowship Training Program
  • Professor of Oncology


Anal Cancer, Bile Duct Cancer, Carcinoid Syndrome, Carcinoid Tumors, Cholangiocarcinoma, Clinical Trials, Colon Cancer, Colorectal Cancer, Gastric Cancer, Gastroesophageal Junction Cancer, Gastrointestinal Cancers, Gastrointestinal Tumors, Hepatocellular Cancer, Liver Cancer, Medical Oncology, Neuroendocrine Tumors, Pancreatic Cancer, Rectal Cancer, Small Bowel Cancer, Small Intestine Cancer, Stomach Cancer more

Research Interests

Gastrointestinal Cancers ; New Anticancer Drug Development ; Pharmacology

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Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

Appointment Phone: 410-955-8964
401 N. Broadway
Baltimore, MD 21231 map

Johns Hopkins Medicine - Green Spring Station

Appointment Phone: 410-583-2970
10753 Falls Road
Pavilion II
Lutherville-Timonium, MD 21093 map



  • Director, Medical Oncology/Hematogy Fellowship Training Program
  • Director, Division of Medical Oncology
  • Virginia and D.K. Ludwig Professor in Clinical Investigation of Cancer
  • Professor of Oncology
  • Professor of Medicine

Departments / Divisions

Centers & Institutes



  • MD, University of Minnesota Medical School (1974)


  • Johns Hopkins University School of Medicine / Internal Medicine (1976)


  • National Institutes of Health / Medical Oncology (1980)

Board Certifications

  • American Board of Internal Medicine / Internal Medicine (1977)
  • American Board of Internal Medicine / Medical Oncology (1979)

Research & Publications

Selected Publications

Gilbert, J.; Carducci, M.A.; Baker, S.D.; Dees, E.C.; Donehower, R. A Phase I study of the oral antimetabolite, CS-682, administered once daily 5 days per week in patients with refractory solid tumor malignancies. Invest New Drugs. 2006 Nov;24(6):499-508.

Messersmith, W.A.; Baker, S.D.; Lassiter, L.; Sullivan, R.A.; Dinh, K.; Almuete, V.I.; Wright, J.J.; Donehower, R.C.; Carducci, M.A.; Armstrong, D.K. Phase I trial of bortezomib in combination with docetaxel in patients with advanced solid tumors. Clin Cancer Res. 2006 Feb 15;12(4):1270-1275.

Sommer, M.; Poliak, N.; Upadhyay, S.; Ratovitski, E.; Nelkin, B.D.; Donehower, L.A.; Sidransky, D. DeltaNp63alpha overexpression induces downregulation of Sirt1 and an accelerated aging phenotype in the mouse. Cell Cycle. 2006 Sep;5(17):2005-2011.

Blakeley, J.; Laterra, J. Neurotoxicities. In: Ettinger, D.S.; Donehower, R., editors, Current Cancer in Therapeutics: Springer; 2007.

Dunbar, E.; Laterra, J. Malignant glioma. In: Ettinger, D.S.; Donehower, R., editors: Current Cancer Therapeutics; 2007. p. In press.

Li, J.; Zhao, M.; Jimeno, A.; He, P.; Ramana Reddy, M.V.; Hidalgo, M.; Donehower, R.C.; Rudek, M.A. Validation and implementation of a liquid chromatography/tandem mass spectrometry assay to quantitate ON 01910.Na, a mitotic progression modulator, in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Sep 1;856(1-2):198-204.

Messersmith, W.A.; Rudek, M.A.; Baker, S.D.; Zhao, M.; Collins, C.; Colevas, A.D.; Donehower, R.C.; Carducci, M.A.; Wolff, A.C. Phase I study of continuous weekly dosing of dimethylamino benzoylphenylurea (BPU) in patients with solid tumours. Eur J Cancer. 2007 Jan;43(1):78-86.

Brahmer, J.R. Lung Cancer. In: Donehower, R.; Ettinger, D., editors. 5th Edition ed, Current Cancer Therapeutics. New York, NY: Churchill-Livingstone; 2008.

Brandes, J.C.; Yung, R.C. Pulmonary and Cardiovascular Complications of Cancer Therapy. In: Ettinger, D.; Donehower, R., editors, Current Cancer Therapeutics, Fifth Edition: Current Medicine, LLC; 2008.

Herman, J.M.; Swartz, M.J.; Hsu, C.C.; Winter, J.; Pawlik, T.M.; Sugar, E.; Robinson, R.; Laheru, D.A.; Jaffee, E.; Hruban, R.H.; Campbell, K.A.; Wolfgang, C.L.; Asrari, F.; Donehower, R.; Hidalgo, M.; Diaz, L.A., Jr.; Yeo, C.; Cameron, J.L.; Schulick, R.D.; Abrams, R. Analysis of fluorouracil-based adjuvant chemotherapy and radiation after pancreaticoduodenectomy for ductal adenocarcinoma of the pancreas: results of a large, prospectively collected database at the Johns Hopkins Hospital. J Clin Oncol. 2008 Jul 20;26(21):3503-3510.

Jimeno, A.; Li, J.; Messersmith, W.A.; Laheru, D.; Rudek, M.A.; Maniar, M.; Hidalgo, M.; Baker, S.D.; Donehower, R.C. Phase I study of ON 01910.Na, a novel modulator of the Polo-like kinase 1 pathway, in adult patients with solid tumors. J Clin Oncol. 2008 Dec 1;26(34):5504-5510.

Jimeno, A.; Messersmith, W.A.; Lee, C.K.; Ma, W.W.; Laheru, D.; Donehower, R.C.; Baker, S.D.; Hidalgo, M. Phase I study of troxacitabine administered by continuous infusion in subjects with advanced solid malignancies. Ann Oncol. 2008 Feb;19(2):374-379.

Jimeno, A.; Rudek, M.A.; Kulesza, P.; Ma, W.W.; Wheelhouse, J.; Howard, A.; Khan, Y.; Zhao, M.; Jacene, H.; Messersmith, W.A.; Laheru, D.; Donehower, R.C.; Garrett-Mayer, E.; Baker, S.D.; Hidalgo, M. Pharmacodynamic-guided modified continuous reassessment method-based, dose-finding study of rapamycin in adult patients with solid tumors. J Clin Oncol. 2008 Sep 1;26(25):4172-4179.

Jimeno, A.; Rudek, M.A.; Purcell, T.; Laheru, D.A.; Messersmith, W.A.; Dancey, J.; Carducci, M.A.; Baker, S.D.; Hidalgo, M.; Donehower, R.C. Phase I and pharmacokinetic study of UCN-01 in combination with irinotecan in patients with solid tumors. Cancer Chemother Pharmacol. 2008 Mar;61(3):423-433.

Laheru, D.; Croghan, G.; Bukowski, R.; Rudek, M.; Messersmith, W.; Erlichman, C.; Pelley, R.; Jimeno, A.; Donehower, R.; Boni, J.; Abbas, R.; Martins, P.; Zacharchuk, C.; Hidalgo, M. A phase I study of EKB-569 in combination with capecitabine in patients with advanced colorectal cancer. Clin Cancer Res. 2008 Sep 1;14(17):5602-5609.

Le, D.; Kim, P.; Jaffee, E.M. Current Cancer Therapeutics. In: David Ettinger, R.D., editor, Cancer Vaccines. Philadelphia: Current Medicine, LLC; 2008.

Messersmith, W.A.; Jimeno, A.; Ettinger, D.; Laheru, D.; Brahmer, J.; Lansey, D.; Khan, Y.; Donehower, R.C.; Elsayed, Y.; Zannikos, P.; Hidalgo, M. Phase I trial of weekly trabectedin (ET-743) and gemcitabine in patients with advanced solid tumors. Cancer Chemother Pharmacol. 2008 Dec;63(1):181-188.

Jimeno, A.; Chan, A.; Cusatis, G.; Zhang, X.; Wheelhouse, J.; Solomon, A.; Chan, F.; Zhao, M.; Cosenza, S.C.; Ramana Reddy, M.V.; Rudek, M.A.; Kulesza, P.; Donehower, R.C.; Reddy, E.P.; Hidalgo, M. Evaluation of the novel mitotic modulator ON 01910.Na in pancreatic cancer and preclinical development of an ex vivo predictive assay. Oncogene. 2009 Jan 29;28(4):610-618.

Lin, J.; Gilbert, J.; Rudek, M.A.; Zwiebel, J.A.; Gore, S.; Jiemjit, A.; Zhao, M.; Baker, S.D.; Ambinder, R.F.; Herman, J.G.; Donehower, R.C.; Carducci, M.A. A phase I dose-finding study of 5-azacytidine in combination with sodium phenylbutyrate in patients with refractory solid tumors. Clin Cancer Res. 2009 Oct 1;15(19):6241-6249.

Garrido-Laguna, I.; Tan, A.C.; Uson, M.; Angenendt, M.; Ma, W.W.; Villaroel, M.C.; Zhao, M.; Rajeshkumar, N.V.; Jimeno, A.; Donehower, R.; Iacobuzio-Donahue, C.; Barrett, M.; Rudek, M.A.; Rubio-Viqueira, B.; Laheru, D.; Hidalgo, M. Integrated preclinical and clinical development of mTOR inhibitors in pancreatic cancer. Br J Cancer. 2010 Aug 24;103(5):649-655.
Husain, H.; Cosgrove, D.; Donehower, R. Adenocarcinoma of Unknown Primary. In: Group, B., editor. Vol. Online Database-Not Supported Through NIH Funding, BMJ Point of Care: BMJ Group; 2010.

Lin, J.; Donehower, R.C. Make quality cancer survivorship care possible in the era of workforce shortage. J Oncol Pract. 2010 Jan;6(1):52-53.

Ma, W.W.; Herman, J.M.; Jimeno, A.; Laheru, D.; Messersmith, W.A.; Wolfgang, C.L.; Cameron, J.L.; Pawlik, T.M.; Donehower, R.C.; Rudek, M.A.; Hidalgo, M. A tolerability and pharmacokinetic study of adjuvant erlotinib and capecitabine with concurrent radiation in resected pancreatic cancer. Transl Oncol. 2010;3(6):373-379.

Messersmith, W.A.; Jimeno, A.; Jacene, H.; Zhao, M.; Kulesza, P.; Laheru, D.A.; Kahn, Y.; Spira, A.; Dancey, J.; Iacobuzio-Donahue, C.; Donehower, R.C.; Carducci, M.; Rudek, M.A.; Hidalgo, M. Phase I trial of oxaliplatin, infusional 5-fluorouracil, and leucovorin (FOLFOX4) with erlotinib and bevacizumab in colorectal cancer. Clin Colorectal Cancer. 2010 Dec;9(5):297-304.

Weekes, C.D.; Nallapareddy, S.; Rudek, M.A.; Norris-Kirby, A.; Laheru, D.; Jimeno, A.; Donehower, R.C.; Murphy, K.M.; Hidalgo, M.; Baker, S.D.; Messersmith, W.A. Thymidylate synthase (TYMS) enhancer region genotype-directed phase II trial of oral capecitabine for 2nd line treatment of advanced pancreatic cancer. Invest New Drugs. 2010 Mar 23.

Villarroel, M.C.; Rajeshkumar, N.V.; Garrido-Laguna, I.; De Jesus-Acosta, A.; Jones, S.; Maitra, A.; Hruban, R.H.; Eshleman, J.R.; Klein, A.; Laheru, D.; Donehower, R.; Hidalgo, M. Personalizing Cancer Treatment in the Age of Global Genomic Analyses: PALB2 Gene Mutations and the Response to DNA Damaging Agents in Pancreatic Cancer. Mol Cancer Ther. 2011 Jan;10(1):3-8.

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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