Dr. Troncoso’s research focuses on the neuropathology of normal aging and the pathology, pathogenesis and therapy of neurodegenerative disorders.
His research encompasses clinical-pathological correlations, morphological studies using unbiased stereology and investigations of the pathogenesis of neurodegenerative disorders in relevant genetically engineered mouse models and in vitro systems.
Dr. Troncoso’s laboratory has conducted apoE genotyping for more than a decade, serving the Division of Neuropathology and other investigators in the JHMI research community.
Clinical and Neuropathology Core, Udall Center
- Iacono D, Resnick SM, O'Brien R, Zonderman AB, An Y, Pletnikova O, Rudow G, Crain B, Troncoso JC. "Mild cognitive impairment and asymptomatic Alzheimer disease subjects: equivalent β-amyloid and tau loads with divergent cognitive outcomes." J Neuropathol Exp Neurol. 2014 Apr;73(4):295-304. doi: 10.1097/NEN.0000000000000052.
- Riudavets MA, Bartoloni L, Troncoso JC, Pletnikova O, St George-Hyslop P, Schultz M, Sevlever G, Allegri RF. "Familial dementia with frontotemporal features associated with M146V presenilin-1 mutation." Brain Pathol. 2013 Sep;23(5):595-600. doi: 10.1111/bpa.12051. Epub 2013 Apr 25.
- Driscoll I, Troncoso JC, Rudow G, Sojkova J, Pletnikova O, Zhou Y, Kraut MA, Ferrucci L, Mathis CA, Klunk WE, O'Brien RJ, Davatzikos C, Wong DF, Resnick SM. "Correspondence between in vivo (11)C-PiB-PET amyloid imaging and postmortem, region-matched assessment of plaques." Acta Neuropathol. 2012 Dec;124(6):823-31. doi: 10.1007/s00401-012-1025-1. Epub 2012 Aug 5.
- Airavaara M, Pletnikova O, Doyle ME, Zhang YE, Troncoso JC, Liu QR. "Identification of novel GDNF isoforms and cis-antisense GDNFOS gene and their regulation in human middle temporal gyrus of Alzheimer disease." J Biol Chem. 2011 Dec 30;286(52):45093-102. doi: 10.1074/jbc.M111.310250. Epub 2011 Nov 11.
West MJ, Coleman PD, Flood DG, Troncoso JC. Differences in the pattern of hippocampal neuronal loss in normal aging and Alzheimer's disease. Lancet 344:769-772, 1994.
Troncoso JC, Martin LJ, Dal Forno G, Kawas CH. Neuropathology in controls and demented subjects from the Baltimore Longitudinal Study of Aging. Neurobiol. Aging 17:365-371, 1996.
Vehmas AK, Borchelt DR, Price DL, McCarthy D, Wills-Karp M, Peper M, Rudow G, Luyinbazi J, Siew L, Troncoso J. Beta-amyloid peptide vaccination results in marked changes in serum and brain A-beta levels in APPswe/PS1?E9 mice, as detected by SELDI-TOF-based ProteinChip® technology. DNA and Cell Biology 20:713-721, 2001.
West MJ, Kawas CH, Stewart WF, Rudow GL, Troncoso JC. Hippocampal neurons in pre-clinical Alzheimers disease. Neurobiology of Aging 25(9):1205-12, 2004.
Pletnikova O, West N, Lee MK, Rudow G, Skolasky RL, Dawson TM, Marsh L, Troncoso JC. Aβ deposition enhances cortical α-synuclein lesions in Parkinsons disease. Accepted for publication in Neurobiology of Aging.