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David Joel Hackam, M.D., Ph.D.

Photo of Dr. David Joel Hackam, M.D., Ph.D.

Surgeon-in-Chief, Johns Hopkins Children's Center

Professor of Surgery

Male

Expertise: Crohn's Disease, Diaphragmatic Hernia, General Surgery, Necrotizing Enterocolitis, Neonatal Surgery, Pediatric Surgery, Short Bowel Syndrome, Tracheoesophageal Fistula ...read more

Research Interests: Traumatic intestinal injury; Tracheoesophageal fistula; Diaphragmatic hernia; Phagocytosis in neonatal inflammation; Intestinal epithelial cells under conditions of inflammation; Short bowel syndrome; Crohn's disease; Necrotizing enterocolitis ...read more

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Locations

The Johns Hopkins Hospital (Main Entrance)
Appointment Phone: 410-955-5210

1800 Orleans St.
The Charlotte R. Bloomberg Children's Center Building, Suite 7310
Baltimore, MD 21287 map
Phone: 410-955-5210

York – WellSpan
Appointment Phone: 717-812-4390

300 Pine Grove Commons
Suite 300
York, PA 17403 map

Background

David J. Hackam, M.D., Ph.D., is the Garrett Family Professor of Pediatric Surgery at The Johns Hopkins University, and Pediatric Surgeon-in-Chief and co-Director of the Johns Hopkins Children’s Center.

Dr. Hackam’s clinical practice focuses on complex neonatal surgery. His laboratory is focused on unraveling the molecular mechanisms that underlie several important surgical diseases, including necrotizing enterocolitis and inflammatory bowel disease, and seeks to develop novel therapeutic strategies to prevent or reverse these disease processes. Dr. Hackam’s team has developed techniques of intestinal stem cell isolation and culture, and are working with tissue engineers and chemists towards the development of an artificial intestine, which has been tested in large and small pre-clinical models.  

Dr. Hackam’s work has led to the filing of several international patents, and has been funded by the National Institutes of Health as well as several industry collaborations. Dr. Hackam seeks to work with industry partners, as well as nurses, doctors and families of patients around the country, in order to develop novel regimens to safely and effectively deliver appropriate nutrition to the most vulnerable infants, who are at risk for the development of intestinal disease.

...read more

Titles

  • Surgeon-in-Chief, Johns Hopkins Children's Center
  • Professor of Surgery
  • Professor of Cell Biology

Education

Degrees

  • MD, University of Western Ontario (1992)

Residencies

  • Toronto General Hospital / General Surgery (2000)

Fellowships

  • Children's Hospital of Pittsburgh-UPMC / Pediatric Surgery (2002)

Board Certifications

  • American Board of Surgery / General Surgery (2001)
  • American Board of Surgery / Pediatric Surgery (2004)

Research & Publications

Lab

David Hackam’s laboratory focuses on necrotizing enterocolitis (NEC), a devastating disease of premature infants and the leading cause of death and disability from gastrointestinal disease in newborns.

Lab Website: The Hackam Lab

Selected Publications

View all on Pubmed

Neal MD, Sodhi CP, Jia H, Dyer M, Egan C, Yazji I, Good M, Afrazi A, Marino R, Slagle D, Ma C, Branca MF, Prindle T, Grant Z, Ozolek J, Hackam DJ. Toll like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53-upregulated modulator of apoptosis. J Biol Chem. 2012 Sep 6. [Epub ahead of print]

Misty Good, Richard Siggers, Chhinder P. Sodhi, Amin Afrazi, Feras Alkhudari, Charlotte E. Egan, Matthew D. Neal, Ibrahim Yazji, Hongpeng Jia, Joyce Lin, Maria F. Branca, Congrong Ma, Thomas Prindle, Zachary Grant, Sapana Shah, Dennis Slagle II, Jose Paredes, John Ozolek, George Gittes, David J. Hackam. Amniotic Fluid Inhibits Toll Like Receptor 4 Signaling in the Fetal and Neonatal Intestinal Epithelium. Proceedings of the National Academy of Sciences (PNAS). In Press 2012.

Yi H, Patel AK, Sodhi CP, Hackam DJ, Hackam AS. Novel Role for the Innate Immune Receptor Toll-Like Receptor 4 (TLR4) in the Regulation of the Wnt Signaling Pathway and Photoreceptor Apoptosis. PLoS One. 2012;7(5):e365560. Epub 2012 May 17.

Activities & Honors

Honors

  • Roberta Simmons Chair Honoree
  • Watson Award Nominee, Alpha Omega Alpha Medical Society (Nominated by University of Pittsburgh medical students)
  • Who's Who in Medical Sciences Education
  • Exceptional Patient Satisfaction Award, Children's Hospital of Pittsburgh
  • University of Pittsburgh School of Medicine, Excellence in Education Awards Nominee (Nominated by 1st & 2nd year medical students)
  • Outstanding Surgeon Award, Children's Hospital of Pittsburgh
  • Outstanding Surgeon Award Nominee, Children's Hospital of Pittsburgh
  • First Prize - Oral Presentation, Canadian Association of Pediatric Surgeons
  • William S. Fenwick Research Award, University of Toronto
  • First Prize - Oral Presentation, University of Toronto Annual Assembly of General Surgeons
  • Canadian Research Gold Medal for Specialty Residents in Surgery, Royal College of Physicians and Surgeons of Canada
  • Davis and Geck Award (Basic science contribution by clinical researcher), Canadian Association of General Surgeons
  • Andrew Sass-Kortsak Research Award (Nominated by all students/fellows), Hospital for Sick Children Research Institute
  • Basic Science Research Award (Abstract), Eastern Student Research Forum
  • Institute of Medical Science Research Award (Abstract), University of Toronto
  • Canadian Association of Pediatric Surgeons Resident Award, First Place - Oral Presentation at Annual Meeting
  • American Society for Cell Biology Predoctoral Research Award, Basic Science Competition - Abstract
  • First Prize - Basic Science Poster, Institute of Medical Science Scientific Day
  • Gallie-Batemen Research Award, University of Toronto
  • Resident Research Award for Novel Research Design and Experimentation, University of Toronto
  • University of Toronto Annual Assembly of General Surgeons, First Prize - Oral Presentation
  • Surgical Infection Society Resident Award, First Prize - Oral Presentation
  • Predoctoral Research Award, American Society of Cell Biology
  • Medical Research Council of Canada Research Fellowship
  • Resident Research Fellowship, Ethicon Society of University Surgeons
  • Hospital for Sick Children Research Fellowship
  • Province of Ontario Graduate Scholarship (Declined)
  • Laidlaw Prize - Honorable Mention, Institute of Medical Science
  • Gallie-Bateman Research Award, University of Toronto
  • Honorable Mention for Basic Science, Eastern Student Research Forum
  • Surgical Alumni Scholarship, University of Toronto
  • Research Fellowship, Hospital for Sick Children
  • Graduation Class of 1992, University of Western Ontario
  • Dean's Honor Roll, Academic Excellence in Medical School
  • Award of Academic Excellence, University of Western Ontario
  • Dean's Honor Roll, University of Western Ontario
  • Watson Chair Honoree, University of Pittsburgh School of Medicine Department of Surgery
  • American Surgical Association, Elected member
  • Hartwell Biomedical Research Collaboration Award, 2011

Memberships

  • Alpha Omega Alpha Honor Medical Society
  • American Academy of Pediatrics
  • American Association for the Advancement of Science
  • American College of Surgeons
    Candidate Member
  • American Gastroenterological Association
  • American Society for Biochemistry and Molecular Biology
  • American Society for Cell Biology
  • American Surgical Association
  • Association for Academic Surgery
    Active Member, Nominating Committee
  • Canadian Medical Association
  • Ontario Medical Association
  • Shock Society
  • Society of University Surgeons
    Treasurer
  • Surgical Infection Society
    Ad Hoc By-Laws Committee, Editorial Board

Professional Activities

  • President, Society of University Surgeons

Videos & Media

2017 NEC Symposium Highlight Reel

Recent News Articles and Media Coverage

Esteemed Surgeon-Scientist Named Pediatric Surgeon-in-Chief at Johns Hopkins

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