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Bruce Jeffrey Trock, M.P.H., Ph.D.

Photo of Dr. Bruce Jeffrey Trock, M.P.H., Ph.D.
  • Director, Division of Epidemiology, Brady Urological Institute at Johns Hopkins
  • Professor of Urology

Research Interests

Prostate cancer; Prognostic and predictive biomarkers; Prostate cancer outcomes; Precision medicine; Biostatistical models of aging and cancer. ...read more

Background

Dr. Bruce Jeffrey Trock is the Frank Hinman Jr. endowed Professor of Urology, and is Professor of Epidemiology and Oncology at the Johns Hopkins School of Medicine. He serves as the Director of the Division of Epidemiology in the Brady Urological Institute at Johns Hopkins. His research focuses on prostate cancer.  Prior to joining Johns Hopkins, Dr. Trock was a tenured associate professor at Georgetown University’s Lombardi Cancer Center, where he was also Director of the Cancer Biomarker Resource, with prior positions at the Fox Chase Cancer Center, and the University of Pennsylvania.

In addition to his faculty appointments at Johns Hopkins, Dr. Trock is the Director of the Biostatistics Core for the Johns Hopkins Specialized Program of Research Excellence (SPORE) in Prostate Cancer.  He also was the founding Director, and is now Co-Director of the Prostate Cancer Biorepository Network, a collaboration between the Johns Hopkins University School of Medicine, the New York University School of Medicine, University of Washington, the Institute of Cancer Research (London), Washington University,  and the United States Department of Defense that provides high quality, well-annotated prostate cancer tissues and biospecimens to prostate cancer researchers worldwide.

Dr. Trock has authored or co-authored more than 270 published articles and has been principal or co-principal investigator on numerous research grants.

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Titles

  • Director, Division of Epidemiology, Brady Urological Institute at Johns Hopkins
  • Frank Hinman, Jr. Professor of Urology
  • Professor of Epidemiology
  • Professor of Oncology
  • Professor of Urology
  • Professor of Oncology

Departments / Divisions

Centers & Institutes

Education

Degrees

  • Ph.D., Johns Hopkins Bloomberg School of Public Health (Maryland) (1986)
  • M.P.H., University of Michigan (Michigan) (1979)
  • B.S., Michigan State University (Michigan) (1976)
  • B.S., University of Michigan (Michigan) (1974)

Research & Publications

Research Summary

Dr. Trock’s research goal is the use of biomarkers to better understand prostate cancer etiology, and to advance a precision medicine approach to prostate cancer prognosis and predicting response to therapies.  His academic contributions bridge epidemiology, biostatistics, basic sciences, and clinical trials, with a clear translational focus.   He is also interested in statistical issues involving biomarkers and statistical models to explore the relationship between aging and prostate cancer, as well as common pathways linking breast and prostate cancer etiology.

Selected Publications

View all on Pubmed

Tan M, Shao C, Bishop JA, Feng Z, Trock BJ, Westra WH, Ha PK. "Aquaporin-1 Promoter Hypermethylation Is Associated with Improved Prognosis in Salivary Gland Adenoid Cystic Carcinoma." Otolaryngol Head Neck Surg. 2014 Feb 3. [Epub ahead of print]

Inoue LY, Trock BJ, Partin AW, Carter HB, Etzioni R. "Modeling grade progression in an active surveillance study." Stat Med. 2013 Oct 9. doi: 10.1002/sim.6003. [Epub ahead of print].

Darshan M, Zheng Q, Fedor HL, Wyhs N, Yegnasubramanian S, Lee P, Melamed J, Netto GJ, Trock BJ, De Marzo AM, Sfanos KS. "Biobanking of derivatives from radical retropubic and robot-assisted laparoscopic prostatectomy tissues as part of the prostate cancer biorepository network." Prostate. 2014 Jan;74(1):61-9. doi: 10.1002/pros.22730. Epub 2013 Sep 21].

Kaye DR, Hyndman ME, Segal RL, Mettee LZ, Trock BJ, Feng Z, Su LM, Bivalacqua TJ, Pavlovich CP. "Urinary outcomes are significantly affected by nerve sparing quality during radical prostatectomy." Urology. 2013 Dec;82(6):1348-53. doi: 10.1016/j.urology.2013.06.067. Epub 2013 Oct 3

Patel HD, Feng Z, Landis P, Trock BJ, Epstein JI, Carter HB. "Prostate Specific Antigen Velocity Risk Count Predicts Biopsy Reclassification for Men with Very Low Risk Prostate Cancer." J Urol. 2013 Sep 20. pii: S0022-5347(13)05468-2. doi: 10.1016/j.juro.2013.09.029. [Epub ahead of print].

Contact for Research Inquiries

600 N. Wolfe St.
Jefferson Street. Building, Rm. 149
Baltimore, MD 21287-8915 map

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Activities & Honors

Memberships

  • American Association for Cancer Research
  • American Society of Preventive Oncology
  • Society for Epidemiologic Research

Professional Activities

  • Director, Prostate Cancer Biorepository Network

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