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Paula Jill Hurley, Ph.D.

Photo of Dr. Paula Jill Hurley, Ph.D.

Assistant Professor of Urology

Research Interests: Factors in the tumor microenvironment that mediate metastatic progression; plasma tumor DNA as a biomarker.



  • Assistant Professor of Urology
  • Assistant Professor of Oncology

Departments / Divisions



  • B.A., Lawrence University (Wisconsin) (1967)
  • Ph.D., University of Chicago (Illinois) (2004)

Research & Publications

Selected Publications

Hurley PJ, Wilsker D, Bunz F. Human cancer cells require ATR for cell cycle progression following exposure to ionizing radiation. Oncogene 2007;26(10):2535-42. PubMed PMID: 17043649.

Hurley PJ, Bunz F. ATM and ATR: components of an integrated circuit. Cell Cycle 2007. Feb 15; 6(4):414-7. PubMed PMID: 17312392.

Hurley PJ, Marchionni L, Simons BW, Ross AE, Peskoe S, Miller RM, Erho NG, Vergara IA, Ghadessi M, Huang Z, Gurel B, Park BH, Davicioni E, Jenkins RB, Platz EA, Berman DM, Schaeffer EM. SPARCL1/Hevin is down regulated in aggressive prostate cancers and is prognostic for poor clinical outcome. PNAS 2012. Sep 109(37):14977-82. PubMed PMID: 22927397. PMCID: PMC2443123.

Hurley PJ,Hughes RM, Simons BW, Huang J, Miller RM, Shinder B, Haffner MC, Esopi D, Kimura Y, Jabbari J, Ross AE, Erho N, Vergara IA, Faraj SF, Davicioni E, Netto GJ, Yegnasubramanian S, An SS, Schaeffer EM. Androgen Regulated SPARCL1 in the Tumor Microenvironment Inhibits Metastatic Progression. Cancer Res. 2015. Oct 75(20):4322-34. PubMed PMID: 26294211. PCMID: PMC4609262.

Hurley PJ, Sundi D, Simons BW, Hughes RM, Miller RM, Shinder B, Benzon B, Faraj SF, Netto GJ, Vergara IA, Erho N, Davicioni E, Karnes RJ, Yan Guifang, Ewing C, Isaacs SD, Berman DM, Rider JR, Jordahl KM, Mucci LA, Park BH, Isaacs WB, Marchionni L, Ross AE, Schaeffer EM. Germline ASPN Variants in the Tumor Microenvironment and Risk of Metastatic Prostate Cancer Progression. Clinical Cancer Research 2016. Jan 22(2):448-58. Pubmed PMID: 26446945. PMCID: PMC4715968.

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