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School of Medicine
Feng-Quan Zhou, Ph.D.
Associate Professor of Orthopaedic Surgery
Research Interests: Live cell imaging of signal transduction and cytoskeletal reorganization in neurons; Epigenetic regulation of neuronal morphogenesis during development and regeneration; Promoting axon regeneration after spinal cord or brain injuries; GSK3 signaling in neural development ...read more
Dr. Fengquan Zhou is an associate professor of orthopaedic surgery and neuroscience at the Johns Hopkins School of Medicine. He specializes in spinal cord injuries, autism and cell biology.
Dr. Zhou’s current research focuses on molecular mechanisms of axon growth and guidance during neural development, and axon regeneration after injuries to the central nervous system or peripheral nerves.
He received his undergraduate degree in biochemistry and molecular biology in 1992 from Nanjing University in China, where he also completed an M.S. in the same discipline in 1995. He then completed a Ph.D. in anatomy and cell biology at the State University of New York at Buffalo in 2001. After the conclusion of a postdoctoral fellowship in neuroscience at University of North Carolina at Chapel Hill, he joined the Johns Hopkins faculty in 2005.
Dr. Zhou’s research has won grant awards from the Whitehall Foundation, The March of Dimes Birth Defect Foundation, the Christopher and Dana Reeve Foundation, the Mental Health Research Association, the Alzheimer’s Association, and the Craig H. Neilsen Foundation. In 2013, Dr. Zhou was named associate editor of the Journal of Neuroscience.
- Associate Professor of Orthopaedic Surgery
- Associate Professor of Neuroscience
University of North Carolina at Chapel Hill, Chapel Hill, NC, 2005, Postdoctoral Fellow, Neuroscience
Research & Publications
The Zhou lab seeks to understand the molecular mechanisms underlying development of the mammalian nervous system. Specifically, this includes understanding how neurons generate their complex morphology and form proper circuitries during development, and how neurons regenerate to restore connections after brain or spinal cord injuries.
Lab Website: Zhou Lab
Saijilafu, Hur E-M, Liu C-M, Jiao Z-X, Xu W-L, and Zhou F-Q. "PI3K-GSK3 pathway regulates mammalian axon regeneration by induction of Smad1." Nature Communications. 2013 Oct; 4:2690. doi:10.1038/ncomms3690
Liu C-M, Wang R-Y, Saijilafu, Jiao Z-X, Zhang B-Y, and Zhou F-Q. "MicroRNA-138 and SIRT1 form a mutual negative feedback loop to regulate mammalian axon regeneration." Genes & Development. 2013 June; 27(13):1473-83. doi: 10.1101/gad.209619.112
Saijilafu, Zhang B-Y, and Zhou F-Q. "Signaling pathways that regulate axon regeneration." Neuroscience Bulletin. 2013 Aug; 29(4):411-20.
Byun J, Kim B-T, Kim Y-T, Hur E-M, and Zhou F-Q. "Slit2 inactivates GSK3beta to signal neurite outgrowth inhibition." PLoS One. 2012; 7(12):e51895.
Saijilafu and Zhou F-Q. "Genetic study of axon regeneration with cultured adult dorsal root ganglion neurons." Journal of Visualized Experiments (JoVE), 2012; (66): e4141. doi:10.3791/4141
Academic Affiliations & Courses
Graduate Program Affiliation
Department of Neuroscience
Activities & Honors
- Research Grant Award, The Graig H. Neilsen Foundation, 2011 - 2013
- New Investigator Research Award, Alzheimer's Association, 2010 - 2012
- Young Investigator Award, NARSAD - The Mental Health Research Association, 2008 - 2010
- Research Grant Award, Christopher and Dana Reeve Foundation, 2007 - 2008
- Basil O'Connor Starter Scholar Research Award, March of Dimes Birth Defect Foundation, 2007 - 2009
- Research Grant Award, Whitehall Foundation, 2006 - 2009
- Associate Editor, Journal of Neuroscience
Videos & Media
Recent News Articles and Media Coverage
A Clearer Path to Axon Regeneration for Brain and Spinal Cord Injuries | Orthopaedic Surgery (November 2017)