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Mei Wan, Ph.D.

Photo of Dr. Mei Wan, Ph.D.
  • Frank J. Frassica Professor of Orthopaedic Surgery
  • Professor of Orthopaedic Surgery

Research Interests

Cellular Senescence; Lineage Fate Change of Mesenchymal Stem/stromal Cells; Skeletal Diseases; Bone-Vascular Interplay

Background

Dr. Mei Wan is the Frank J. Frassica Professor of Orthopaedic Surgery. Her primary research interest is to characterize the mechanisms by which the bone/bone marrow cells change their cell fate and how these changes contribute to skeletal disorders such as osteoporosis and osteoarthritis. Another line of her research interest is to understand the mechanisms underlying the interplay between the skeleton and other organ systems such as vascular system and brain.

Dr. Wan earned her Ph.D. degree from Hebei Medical University in Shijiazhuang, China. She completed her postgraduate training at the University of Alabama at Birmingham. Prior to joining Johns Hopkins, Dr. Wan was an Associate Professor of Pathology at the University of Alabama at Birmingham.

She serves on the editorial boards of The Journal of Bone and Mineral Research and Bone Research. She served as a standing committee member on the VA Endocrinology-B Merit Review study section and has been on the committee of multiple NIH study section panels.

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Titles

  • Frank J. Frassica Professor of Orthopaedic Surgery
  • Professor of Orthopaedic Surgery

Departments / Divisions

Centers & Institutes

Research & Publications

Research Summary

Dr. Wan’s long-term research goal is to understand the mechanisms by which bone cells and bone marrow stem/progenitor cells change their cell state and how the changes contribute to the development of skeletal diseases. Specifically, her research team aims to define the role of cellular senescence in skeletal growth and age-associated skeletal disorders such as osteoporosis and osteoarthritis.

Another line of her research is to understand the cellular and molecular basis by which the bone-derived cues regulate the aging process of vascular system. Dr. Wan and her team are investigating the mechanistic link underlying “bone-vascular axis” and attempt to identify key skeleton-derived pro-aging factors for vascular aging.

Selected Publications

View all on Pubmed

Li C, Zhen G, Xie L, Crane JL, Farber E, Farber CR, Gao P, Cao X, and Wan M. RhoA Determines Lineage Fate of MSCs by Modulating CTGF-VEGF Complex in Extracellular Matrix. Nature Communications 2016; Apr 29;7:11455. PMID: 27126736

Li C, Chai Y, Wang L, Gao B, Chen H, Zhou FQ, Luo X, Crane JL, Yu B, Cao X, and Wan M. Programmed Cell Senescence in Skeleton during Late Puberty. Nature Communications 2017; 8(1):1312. PMID:29101351

Wang L, Chai Y, Li C, Liu H, Su W, Liu X, Yu B, Lei W, Yu B, Crane JL, Cao X, and Wan M. Oxidized Phospholipids Are Ligands for LRP6. Bone research 2018 Jul 18; 6:22. PMID:30038821

Su W, Liu G, Liu X, Zhou Y, Sun Q, Zhen G, Wang X, Hu Y, Gao P, Demehri S, Cao X, and Wan M. Angiogenesis Stimulated by Elevated PDGF-BB in Subchondral Bone Contributes to Osteoarthritis Development. JCI Insight 2020; 5(8): e135446. PMID:32208385

Liu X, Chai Y, Liu G, Su W, Guo Q, Lv X, Gao P, Yu B, Ferbeyre G, Cao X, and Wan M. Osteoclasts Protect Bone Blood Vessels Against Senescence through the Angiogenin/Plexin-B2 Axis. Nature Communications 2021 (in press)

Activities & Honors

Memberships

  • American Heart Association
  • American Society for Bone & Mineral Research
  • Endocrinology Society

Professional Activities

  • Editorial board, The Journal of Bone and Mineral Research, 2010
  • Editorial board, Bone Research, 2012
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