Mei Wan, Ph.D.

Headshot of Mei Wan
  • Frank J. Frassica Professor of Orthopaedic Surgery
  • Professor of Orthopaedic Surgery

Research Interests

Cellular Senescence; Skeletal Disorders; Bone-Vascular Crosstalk; Bone-Brain Crosstalk ...read more

Background

Dr. Mei Wan is the Frank J. Frassica Professor of Orthopaedic Surgery. Her research has primarily focused on the mechanisms underlying the senescence of bone and bone marrow cells and the role of these senescent cells in skeletal disorders. Additionally, she has a keen interest in unraveling the impact of bone-derived signals on the aging processes of the central nervous system and vascular system.

Dr. Mei Wan has served as a Ph.D. program faculty for multiple JHU graduate programs, including BME, CMM, and Pathobiology.

Dr. Wan earned her Ph.D. degree from Hebei Medical University. She completed her postgraduate training at the University of Alabama at Birmingham. Prior to joining Johns Hopkins, Dr. Wan was an Associate Professor of Pathology at the University of Alabama at Birmingham.

Dr. Mei Wan has served on the editorial board for Bone Research and as a Reviewing Editor for eLife. Furthermore, she was previously a part of the editorial boards of The Journal of Bone and Mineral Research. In addition to her editorial roles, Dr. Wan has served as a standing member on the NIH SBSR study section.

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Titles

  • Frank J. Frassica Professor of Orthopaedic Surgery
  • Professor of Orthopaedic Surgery
  • Professor of Biomedical Engineering

Departments / Divisions

Centers & Institutes

Research & Publications

Research Summary

Dr. Wan's research has primarily focused on the mechanisms underlying the senescence of bone and bone marrow cells and the role of these senescent cells in skeletal disorders. Additionally, she has a keen interest in unraveling the impact of bone-derived signals on the aging processes of the central nervous system and vascular system.

Selected Publications

View all on PubMed

Li C, Chai Y, Wang L, Gao B, Chen H, Zhou FQ, Luo X, Crane JL, Yu B, Cao X, and Wan M. Programmed Cell Senescence in Skeleton during Late Puberty. Nature Communications 2017; 8(1):1312. PMID:29101351

Liu X, Chai Y, Liu G, Su W, Guo Q, Lv X, Gao P, Yu B, Ferbeyre G, Cao X, and Wan M. Osteoclasts Protect Bone Blood Vessels Against Senescence through the Angiogenin/Plexin-B2 Axis. Nature Communications 2021 ; 12:1706. PMCID: PMC7987975

Liu X, Gu Y, Kumar S, Amin S, Guo Q, Wang J, Fang C-L, Cao X, Wan M. Oxylipin-PPARγ-initiated adipocyte senescence propagates secondary senescence in the bone marrow. Cell Metabolism 2023 Apr 4;35(4):667-684.e6. PMCID: PMC10127143

Santhanam L, Liu G, Jandu S, Su W, Wodu BP, Savage W, Poe A, Liu X, Alexander LM, Cao X, Wan M. Skeleton-derived PDGF-BB mediates arterial stiffening. J Clin Invest. 2021; 130: e147116. PMCID: PMC8516464

Liu G, Wang J, Wei Z, Fang CL, Shen K, Qian C, Qi C, Li T, Gao P, Wong PC, Lu H, Cao X, Wan M. Elevated PDGF-BB from bone impairs hippocampal vasculature by inducing PDGFRβ shedding from pericytes. Advanced Science 2023 Apr 27; e2206938.PMID: 37102631

Academic Affiliations & Courses

Graduate Program Affiliation

BME Graduate Program

CMM Graduate Program

Pathobiology Graduate Program

Activities & Honors

Memberships

  • American Heart Association
  • American Society for Bone & Mineral Research
  • Endocrinology Society

Professional Activities

  • Editorial board, The Journal of Bone and Mineral Research, 2010 - 2014
  • Editorial board, Bone Research, 2012
  • Reviewing Editor, eLife, 2021
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