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Zhiliang Wei, Ph.D.

  • Assistant Professor of Radiology and Radiological Science

Research Interests

Brain Physiology; Disease Models; Alzheimer's Disease; Vascular Dementia; MR Imaging with Novel Molecular Mechanism ...read more

Background

Education

Degrees

  • Ph.D.; Xiamen University (China) (2015)

Research & Publications

Research Summary

Dr. Wei's research focuses on the development and applications of MRI methodologies for evaluating various brain physiological parameters in preclinical disease models. He has developed and optimized the non-contrast-agent MRI techniques to measure the oxygen extraction fraction (OEF), cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO2) in small animals. To gain better insight into the dynamic brain physiology of small animals, he has optimized an hyphenated method (MRI-HPLC) for evaluating cerebrovascular reactivity (CVR).

Selected Publications

Wei Z, Xu J, Liu P, Chen L, Li W, van Zijl PCM, Lu H. Quantitative assessment of cerebral venous blood T2 in mouse at 11.7T: Implementation, optimization, and age effect. Magn Reson Med 2018;80(2):521-528

Wei Z, Chen L, Lin Z, Jiang D, Xu J, Liu P, van Zijl PCM, Lu H. Optimization of phase-contrast MRI for the estimation of global cerebral blood flow of mice at 11.7T. Magn Reson Med 2019;81(4):2566-2575

Wei Z, Chen L, Hou X, van Zijl PCM, Xu J, Lu H. Age-related alterations in brain perfusion, venous oxygenation, and oxygen metabolic rate of mice: A 17-month longitudinal MRI study. Front Neurol 2020;11:559

Wei Z, Wang Q, Modi HR, Cho S-M, Geocadin R, Thakor NV, Lu H. Acute‐stage MRI cerebral oxygen consumption biomarkers predict 24‐hour neurological outcome in a rat cardiac arrest model. NMR Biomed 2020:e4377

Wei Z, Xu J, Chen L, Hirschler L, Barbier EL, Li T, Wong PC, Lu H. Brain metabolism in tau and amyloid mouse models of Alzheimer's disease: An MRI study. NMR Biomed 2021;e4568

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