Dr. Bhujwalla’s research is dedicated to the applications of molecular and functional imaging to understand and target cancer and the tumor microenvironment.
Significant research contributions include:
- Developing ‘theranostic agents’ for image-guided precision targeting of cancer including delivery of siRNA, cDNA, prodrug enzymes, and phototherapy agents,
- Understanding the role of inflammation and cyclooxygenase-2 (COX-2) in cancer using molecular and functional imaging,
- Developing noninvasive imaging techniques to detect COX-2 expression in tumors,
- Understanding the role of hypoxia and choline metabolism in stem-like breast cancer cells,
- Using molecular and functional imaging to understand the role of the tumor microenvironment including the extracellular matrix, hypoxia, vascularization, and choline phospholipid metabolism in cancer invasion and metastasis,
- Molecular and functional imaging characterization of cancer-induced cachexia to understand the cachexia-cascade and identify novel targets in the treatment of this condition,
- Development of cancer cell membrane coated nanoparticles to disrupt cancer cell-stromal cell interactions and induce an immune response.
Cancer Functional Imaging Core
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View all on PubMed
1. Aboagye, E. and Bhujwalla, Z. M. Malignant Transformation Alters Membrane Phospholipid Metabolism of Human Mammary Epithelial Cells. Cancer Research, 59: 80-84, 1999. PRIOR TO 2008
2. Stasinopoulos I, O'Brien DR, Wildes F, Glunde K, and Bhujwalla ZM. Silencing of cyclooxygenase-2 inhibits metastasis and delays tumor onset of poorly differentiated metastatic breast cancer cells. Mol Cancer Res. 5: 435-42, 2007.
3. Chen Z, Penet MF, Nimmagadda S, Li C, Banerjee SR, Winnard PT Jr, Artemov D, Glunde K, Pomper MG, Bhujwalla ZM. PSMA-Targeted Theranostic Nanoplex for Prostate Cancer Therapy. ACS Nano. 6: 7752-62, 2012. PMCID:PMC4066818
4. Krishnamachary B, Penet MF, Nimmagadda S, Mironchik Y, Raman V, Solaiyappan M, Semenza GL, Pomper MG, Bhujwalla ZM. Hypoxia regulates CD44 and its variant isoforms through HIF-1α in triple negative breast cancer. PLoS One. 7: e44078, 2012. PMCID:PMC3429433
5. Winnard PT Jr, Bharti S, Penet MF, Marik R, Mironchik Y, Wildes F, Maitra A, Bhujwalla ZM. Detection of Pancreatic Cancer-induced Cachexia using a Fluorescent Myoblast Reporter System and Analysis of Metabolite Abundance. Cancer Res. 2016; 6(6):1441-50. PMCID: PMC4794402