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Zack Z. Wang, Ph.D.

Zack Z. Wang, Ph.D.

Headshot of Zack Z. Wang
  • Director, Ross Flow Cytometry Core Facility
  • Associate Professor of Medicine

Research Interests

Hematopoietic development of pluripotent stem cells; Molecular regulation of vascular differentiation from human ES and iPS cells; EphB4-ephrinB2 signaling in stem cell differentiation ...read more

Background

Dr. Zack Wang is an Associate Professor of Medicine in the Division of Hematology/ Department of Medicine. He studies the hematopoietic development of pluripotent stem cells, molecular regulation of vascular differentiation from human ES and iPS cells.

Dr. Wang holds a bachelor’s degree from the East China University of Science and Technology and a PhD from the Boston University School of Medicine. He completed postdoctoral research at the Center of Regenerative Medicine at Massachusetts General Hospital and Harvard University Stem Cell Institute.

Dr. Wang started his independent research in Maine Medical Center in 2005, and relocated his lab to Johns Hopkins University in 2012.

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Titles

  • Director, Ross Flow Cytometry Core Facility
  • Associate Professor of Medicine

Departments / Divisions

Centers & Institutes

Education

Degrees

  • Ph.D.; Boston University (Massachusetts) (1998)
  • B.S.; East China University of Science and Technology (China) (1982)

Research & Publications

Research Summary

The long-term research goal of the Wang laboratory is to understand the molecular mechanisms that regulate cardiovascular and hematopoietic differentiation of pluripotent stem cells (PSCs), including embryonic stem (ES) cells and induced-pluripotent stem (iPS) cells. Pluripotent stem cells hold great potential for regenerative medicine, and gene therapy. Defining the molecular links between differentiation outcomes will provide important information for designing rational methods of stem cell manipulation.  

Core Facility:

Selected Publications

View all on PubMed

Shen J, Xu Y, Zhang S, Lyu S, Huo Y, Zhu Y, Tang K, Mou J, Li X, Hoyle DL, Wang M, Wang J, Li X, Wang ZZ, Cheng T. Single-cell transcriptome of early hematopoiesis guides arterial endothelial-enhanced functional T cell generation from human PSCs. Sci Adv. 2021 Sep 3;7(36):eabi9787. doi: 10.1126/sciadv.abi9787. Epub 2021 Sep 3. PubMed PMID: 34516916; PubMed Central PMCID: PMC8442917

Kruse RL, Huang Y, Lee A, Zhu X, Shrestha R, Laeyendecker O, Littlefield K, Pekosz A, Bloch EM, Tobian AAR, Wang ZZ. A Hemagglutination-Based Semiquantitative Test for Point-of-Care Determination of SARS-CoV-2 Antibody Levels. J Clin Microbiol. 2021 Nov 18;59(12):e0118621. doi: 10.1128/JCM.01186-21. Epub 2021 Sep 1. PubMed PMID: 34469185; PubMed Central PMCID: PMC8601214

Shen J, Zhu Y, Lyu C, Feng Z, Lyu S, Zhao Y, Hoyle DL, Ji G, Miao W, Zhang X, Cheng L, Brodsky RA, Cheng T, Wang ZZ. Sequential cellular niches control the generation of enucleated erythrocytes from human pluripotent stem cells. Haematologica. 2020;105(2):e48-e51. doi: 10.3324/haematol.2018.211664. Print 2020. PubMed PMID: 31197070; PubMed Central PMCID: PMC7012464.

Shen J, Lyu C, Zhu Y, Feng Z, Zhang S, Hoyle DL, Ji G, Brodsky RA, Cheng T, Wang ZZ. Defining early hematopoietic-fated primitive streak specification of human pluripotent stem cells by the orchestrated balance of Wnt, activin, and BMP signaling. J Cell Physiol. 2019 Feb 10;. doi: 10.1002/jcp.28272. [Epub ahead of print] PubMed PMID: 30740687; PubMed Central PMCID: PMC6689260

Bai H, Gao Y, Hoyle DL, Cheng T, Wang ZZ. Suppression of Transforming Growth Factor-β Signaling Delays Cellular Senescence and Preserves the Function of Endothelial Cells Derived from Human Pluripotent Stem Cells. Stem Cells Transl Med. 2017 Feb;6(2):589-600. doi: 10.5966/sctm.2016-0089. Epub 2016 Sep 20. PubMed PMID: 28191769; PubMed Central PMCID: PMC5442820

Contact for Research Inquiries

720 Rutland Avenue
Ross Research Building, Room 1029
Baltimore, MD 21205 map
Phone: 410-614-0041

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