Xiaobu Ye is an Assistant Professor of Neurosurgery and Oncology/Biostatistics at the Johns Hopkins School of Medicine (JHMI). She earned her degrees in medicine and an MS in Biostatistics in 1983 and 1994, respectively. She was a faculty member at the Medical University of South Carolina before joining the Division of Oncology Biostatistics at JHMI in 2002.

The main focus of her work has been implementing statistical methods in practical clinical research with an emphasis in clinical trials, relying heavily on scientific rationales in medicine, biology and principles of statistics. Statistical methods include the continual reassessment method (CRM), response surface method, an entropy-based approach, the Bayesian method, and other general statistical approaches to anti-cancer therapeutic development.

Dr. Ye also served as a Senior Statistician for the Center for Complementary and Alternative Medicine and SPORE grants at Johns Hopkins. She is the faculty biostatistician for a research training grant in neuro-oncology mentoring junior investigators in developing basic clinical research skills.

Since 2003, she has been a statistician for the NCI-funded brain tumor clinical trial consortium (ABTC), a collaboration of multiple academic institutions, pharmaceutical companies, and the NCI Cancer Therapy Evaluation Program (CTEP). She is a member of the NCI Brain Malignancies Steering Committee (BMSC) for biostatistics. more


  • Associate Professor of Neurosurgery
  • Associate Professor of Oncology

Departments / Divisions

Centers & Institutes



  • M.S.; Medical University of South Carolina (South Carolina) (1994)
  • M.D.; Zhejiang University (China) (1983)

Research & Publications

Selected Publications

View all on PubMed

  1. Local delivery of angiogenesis-inhibitor minocycline combined with radiotherapy and oral temozolomide chemotherapy in 9L glioma. Bow H, Hwang LS, Schildhaus N, Xing J, Murray L, Salditch Q, Ye X, Zhang Y, Weingart J, Brem H, Tyler B. J Neurosurg. 2014 Mar;120(3):662-9. doi: 10.3171/2013.11.JNS13556. Epub 2013 Dec 20. PMID: 24359008
  2. Establishing percent resection and residual volume thresholds affecting survival and recurrence for patients with newly diagnosed intracranial glioblastoma. Chaichana KL, Jusue-Torres I, Navarro-Ramirez R, Raza SM, Pascual-Gallego M, Ibrahim A, Hernandez-Hermann M, Gomez L, Ye X, Weingart JD, Olivi A, Blakeley J, Gallia GL, Lim M, Brem H, Quinones-Hinojosa A. Neuro Oncol. 2014 Jan;16(1):113-22. doi: 10.1093/neuonc/not137. Epub 2013 Nov 26. PMID: 24285550
  3. Association between severe treatment-related lymphopenia and progression-free survival in patients with newly diagnosed squamous cell head and neck cancer. Campian JL, Sarai G, Ye X, Marur S, Grossman SA. Head Neck. 2013 Oct 31. doi: 10.1002/hed.23535. [Epub ahead of print] PMID: 24174270
  4. Impact on seizure control of surgical resection or radiosurgery for cerebral arteriovenous malformations. Wang JY, Yang W, Ye X, Rigamonti D, Coon AL, Tamargo RJ, Huang J. Neurosurgery. 2013 Oct;73(4):648-55; discussion 655-6. doi: 10.1227/NEU.0000000000000071. PMID: 23842554
  5. Metastatic triple-negative breast cancers at first relapse have fewer tumor-infiltrating lymphocytes than their matched primary breast tumors: a pilot study. Cimino-Mathews A, Ye X, Meeker A, Argani P, Emens LA.Hum Pathol. 2013 Oct;44(10):2055-63. doi: 10.1016/j.humpath.2013.03.010. Epub 2013 May 21. PMID: 23701942


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