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William Reid Thompson III, M.D.

Headshot of William Reid Thompson III
  • Associate Professor of Pediatrics


Cardiomyopathy, Chemotherapy-Induced Cardiomyopathy, Hypertrophic Cardiomyopathy, Muscular Dystrophies, Pediatric Cardiology, Pediatric Congenital Heart Disease more

Research Interests

Stress echo; Use of AI in screening for heart disease; Evaluation of ventricular function; Exploring new methods of teaching cardiac auscultation more

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The Johns Hopkins Hospital (Main Entrance)

Appointment Phone: 443-997-5437
1800 Orleans St.
The Charlotte R. Bloomberg Children's Center Building, Pediatric Cardiology, M2201
Baltimore, MD 21287 map


Dr. W. Reid Thompson is an Associate Professor of Pediatrics at the Johns Hopkins University School of Medicine. His areas of clinical expertise include pediatric cardiology, cardiomyopathy, muscular dystrophy, and echocardiography. Dr. Thompson is a member of the pediatric cardiovascular team at the Heart and Vascular Institute at Johns Hopkins.

Dr. Thompson was born in Chapel Hill, North Carolina. He was a Morehead Scholar at the University of North Carolina, where he was also Phi Eta Sigma and Phi Beta Kappa. He received his M.D. from the Wake Forest University Bowman Gray School of Medicine in Winston-Salem, North Carolina. He completed his residency at Johns Hopkins Hospital and performed a fellowship in pediatric cardiology at The Children’s Hospital – Harvard Medical School.

Dr. Thompson's research interests include evaluation of ventricular function in patients with muscular dystrophy, Barth syndrome, and status post chemotherapy. He also studies novel methods of teaching and diagnosing heart disease through cardiac auscultation. 

Dr. Thompson is a physician at the Johns Hopkins Hospital as well as the Kennedy Krieger Institute. He is certified by the National Board of Medical Examiners, the American Board of Pediatrics, and the American Board of Pediatrics Sub-Board in Cardiology. He was awarded an Individual National Research Service Award by the National Institutes of Health. He was also an American Heart Association Bugher Fellow and a Child Health Research Center New Program Development Awardee. more


  • Associate Professor of Pediatrics

Departments / Divisions

Centers & Institutes



  • MD; Wake Forest University School of Medicine (1984)


  • Pediatrics; Johns Hopkins University School of Medicine (1987)

Board Certifications

  • American Board of Pediatrics (Pediatric Cardiology) (1994)

Research & Publications

Selected Publications

Bilchick KC, Plitt D, Salerno M, Dori Y, Crawford TO, Drachman D, Thompson WR. Prevalence and distribution of regional scar in dysfunctional myocardial segments in Duchenne Muscular Dystrophy based on myocardial tagging and echocardiographic assessments of circumferential strain. J Cardiovasc Magn Reson. 2011; 11:13-20

Leung DG, Herzka DA, Thompson WR, He B, Bibat G, Tennekoon G, Russell SD, Schuleri KH, Lardo AC, Kass DA, Thompson RE, Judge DP, Wagner KR. Sildenafil does not improve cardiomyopathy in Duchenne/Becker muscular dystrophy. Ann Neurol. 2014; 76(4):541-9

Thompson WR, DeCroes B, McClellan R, Rubens J, Vaz FM, Kristaponis K, Avranmopoulos D, Vernon HJ. New targets for monitoring and therapy in Barth Syndrome. Genet Med. 2016; doi:10.1038/gim.2015.204

Tran JC, Ruble K, Loeb DM, Chen ARS, Thompson WR. Automated functional imaging by 2-D speckle tracking echocardiography reveals high incidence of abnormal longitudinal strain in a cohort of pediatric oncology patients. Pediatr Blood Cancer. 2016; 63(6): 1075-80

De Meo R, Matusz PJ, Knebel J-F, Murray MM, Thompson WR, Clarke S. What makes medical students better listeners? Curr Biol. 2016;26:R519-20

Activities & Honors


  • Individual National Research Service Award, National Institutes of Health
  • Bugher Fellow, American Heart Association
  • New Program Development Award, Child Health Research Center
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