William H Sharfman, M.D.

Headshot of William H Sharfman
  • Director, Cutaneous Oncology
  • Associate Professor of Oncology

Specializes in: Adults (18+ years)



Cutaneous Oncology, Dermatology, Gastrointestinal Cancers, Immunotherapy, Lung Cancer, Melanoma, Merkel Cell Carcinoma, Neuroendocrine Tumors ...read more

Research Interests

Novel therapies for high risk and advanced melanoma patients; GI Cancers; Lung Cancer ...read more

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Outside of Maryland & Washington D.C.

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Johns Hopkins Medicine - Green Spring Station

Appointment Phone: 410-616-7660
10803 Falls Road
Pavilion III, Suite 1500
Lutherville, MD 21093 map
Phone: 410-583-2970 | Fax: 410-583-2980


Dr. William H. Sharfman is an associate professor of oncology and dermatology at the Johns Hopkins University School of Medicine. His areas of clinical expertise include cutaneous oncology, dermatology, gastrointestinal cancers and immunotherapy. He helped create the well-established Melanoma Program at the Johns Hopkins Kimmel Cancer Center in 1994. Dr. Sharfman serves as the director of cutaneous oncology and clinical co-director for oncology at the Johns Hopkins Melanoma Program.

He earned his M.D. from the University of Toledo College of Medicine. He completed his residency at Cleveland Clinic and performed a fellowship in hematology and oncology at Cleveland Clinic.

Dr. Sharfman's research interests include novel therapies for high risk and advanced melanoma patients; GI cancers; and lung cancer.

...read more


  • Director, Cutaneous Oncology
  • Clinical Co-Director for Oncology, Johns Hopkins Melanoma Program
  • Mary Jo Rogers Professor of Cancer Immunology and Melanoma Research
  • Associate Professor of Oncology
  • Associate Professor of Dermatology

Departments / Divisions

Centers & Institutes



  • MD; University of Toledo College of Medicine and Life Sciences (1982)


  • Internal Medicine; Cleveland Clinic Foundation (1985)


  • Hematology and Oncology; Cleveland Clinic Foundation (1989)

Board Certifications

  • American Board of Internal Medicine (Hematology) (1992)
  • American Board of Internal Medicine (Internal Medicine) (1986)
  • American Board of Internal Medicine (Medical Oncology) (1989)

Research & Publications

Research Summary

Dr. Sharfman’s research focuses on melanoma, including novel therapies for advanced melanoma patients.

Selected Publications

Lange, J.R.; Fecher, L.; Sharfman, W.H.; Alani, R.M.; Mikkilineni, R.; Topalian, S.L.; Balch, C.M. Melanoma. In: Abeloff MD, A.J., Niederhuber JE, Kastan MB, McKenna WG editor. 4th ed, Abeloffs Clinical Oncology. Philadelphia: Elsevier Inc.; 2008. p. 1229-1252.

Brahmer, J.R.; Drake, C.G.; Wollner, I.; Powderly, J.D.; Picus, J.; Sharfman, W.H.; Stankevich, E.; Pons, A.; Salay, T.M.; McMiller, T.L.; Gilson, M.M.; Wang, C.; Selby, M.; Taube, J.M.; Anders, R.; Chen, L.; Korman, A.J.; Pardoll, D.M.; Lowy, I.; Topalian, S.L. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol. 2010 Jul 1;28(19):3167-3175.

Videos & Media

Lectures and Presentations

  • Skin Cancer 101 with an Emphasis on Melanoma

Recent News Articles and Media Coverage

Two Regattas,” The New York Times, December 24, 2008

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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