William B. Guggino, Ph.D.

Headshot of William B. Guggino
  • Director, Department of Physiology
  • Professor of Physiology

Research Interests

Protein trafficking and localization; Epithelial cell biology; Polycystic kidney disease; Gene therapy; Ion channels; Cystic fibrosis ...read more


Dr. William B. Guggino is a professor of physiology and pediatrics at Johns Hopkins University School of Medicine. He is the director of the Department of Physiology.

An acclaimed cystic fibrosis (CF) researcher, Dr. Guggino also serves as director of the NIH Health Heart, Lung, and Blood Institute’s Cystic Fibrosis Gene Therapy Center (housed at Johns Hopkins) and the Cystic Fibrosis Research Development Program.

Dr. Guggino has dedicated most of his professional life to Johns Hopkins, and his commitment to science is equaled only by his passion for teaching. He has trained and mentored scores of young clinician-scientists in unraveling CF''s mysteries and bringing promising new therapies to patients.

He also has served since 1982 as director of curriculum for first-year medical students, as well as course director in organ-systems physiology and histology.

Among his many accomplishments, Dr. Guggino co-authored with Peter Agre, M.D., a seminal paper published in Science in 1992 detailing the discovery of the first water channel protein. That line of research won Dr. Agre the 2003 Nobel Prize in Chemistry.

Dr. Guggino’s work has been recognized with honors that include the prestigious Doris F. Tulcin Cystic Fibrosis Research Award – which marked his achievements in both research and education – and the Johns Hopkins Excellence in Teaching Award.

Dr. Guggino earned his Ph.D. in zoology from the University of North Carolina at Chapel Hill and his M.S. in comparative physiology from Long Island University. He also holds a B.S. in biology from Brooklyn College.

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  • Director, Department of Physiology
  • Professor of Physiology
  • Professor of Pediatrics

Departments / Divisions

Centers & Institutes


Additional Training

  • Yale University School of Medicine, New Haven, CT, 1982, Renal Physiology

Research & Publications

Research Summary

Dr. Guggino’s research interests include cystic fibrosis (CF), ion channels, gene therapy, polycystic kidney disease, epithelial cell biology, and protein trafficking and localization.

His lab currently is investigating the structure and function of chloride and water channels; trafficking and molecular organization of transport proteins in epithelial cell membranes; and genetic therapies for the correction of defective ion transport in CF cells and patients.

Researchers also are working to identify CF’s specific defect in chloride channel regulation. CF is the most common autosomal recessive disease in North America.


Lab Website: William B. Guggino Lab

Selected Publications

Cebotaru L and Guggino WB. Complement yourself: Transcomplementation rescues partially folded mutant proteins. BiophysRev 6: 169-180, 2014

Cebotaru L, Liu Q, Yanda MK, Boinot C, Outeda P, Huso DL, Watnick T, Guggino WB, and Cebotaru V. Inhibition of histone deacetylase 6 activity reduces cyst growth in polycystic kidney disease. Kidney international 90: 90-99, 2016

Lopes‐Pacheco M, Sabirzhanova I, Rapino D, Morales MM, Guggino WB, and Cebotaru L. Correctors Rescue CFTR Mutations in Nucleotide‐Binding Domain 1 (NBD1) by Modulating Proteostasis. ChemBioChem 17: 493-505, 2016

Santoso NG, Cebotaru L, and Guggino WB. Polycystin-1, 2, and STIM1 interact with IP(3)R to modulate ER Ca release through the PI3K/Akt pathway. Cell Physiol Biochem 27: 715-726, 2011

Wang H, Cebotaru L, Lee H, Yang Q, Pollard B, Pollard H, and Guggino W. CFTR Controls the Activity of NF-κB by Enhancing the Degradation of TRADD. Cell Physiol Biochem 40: 1063-1078, 2016.

Contact for Research Inquiries

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Academic Affiliations & Courses

Graduate Program Affiliation

Cellular and Molecular Medicine

Activities & Honors


  • Excellence in Teaching Award, Johns Hopkins
  • Doris F. Tulcin Cystic Fibrosis Research Award, 2005
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