Venkataramana K Sidhaye, M.D.

Dr. Sidhaye’s research focuses on lung epithelial biology. As a principal investigator on several university and NIH sponsored grants, she has strong methodological training in bench and translational investigation. Using primary human differentiated lung cell culture models exposed to environmental particles involved in lung disease, including cigarette smoke, air pollution such as ambient/household air PM2.5, and aerosolized pollutants such as oils and dispersants, she has created in vitro exposure system to assess cellular and molecular dysregulation that leads to disease development.  Using these systems she can expose primary human cells to a variety of aerosolized particles while live imaging of cellular function including measuring cilary beat frequency and track intracellular proteins.  Her focus has been on molecular mechanisms by which critical epithelial proteins regulate cellular function, including cell-cell adhesive proteins such as E-cadherin, cytoskeletal proteins including actin-myosin and microtubules, as well as proteins involved in secretion and maintenance of airway surface liquid.

https://www.sidhayelabjhmi.com