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Venkataramana K Sidhaye, M.D.

Headshot of Venkataramana K Sidhaye
  • Associate Director of the Physician-Scientist Pathway, Osler Residency Program
  • Associate Professor of Medicine


Pulmonary and Critical Care Medicine

Research Interests

Airway epithelial biology; Lung epithelial biology; Airway epithelial permeability; Aquaporins in the lung more

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The Johns Hopkins Hospital (Main Entrance)

Appointment Phone: 410-550-5864
1800 Orleans St.
Sheikh Zayed Tower
Baltimore, MD 21287 map

Johns Hopkins Outpatient Center

Appointment Phone: 410-550-5864
601 N. Caroline St.
Baltimore, MD 21287 map

Johns Hopkins Bayview Medical Center

Appointment Phone: 410-550-5864
4940 Eastern Avenue
Baltimore, MD 21224 map


Dr. Sidhaye is a specialist in Pulmonary and Critical Care Medicine. She is an expert in the diagnosis and management of medical causes of critical illness, including acute respiratory failure, hypotension and shock, pulmonary embolism, diabetic ketoacidosis and hyperosmolar states.

Her lab is focused on studying lung epithelial responses to insults from non-infectious particles such as cigarette smoke and particulate matter as well as infectious insults such as virus and bacteria.  A primary focus of the lab is in epithelial monolayer integrity and quantitative analysis of epithelial dysfunction with the goal of driving the epithelium towards health.

Dr. Sidhaye serves as the associate director of the Physician Scientist Pathway in the Osler Residency Program at Johns Hopkins.

She received her M.D. from the Feinberg School of Medicine at Northwestern University. She completed her residency at Northwestern and performed a fellowship in pulmonary and critical care medicine at Johns Hopkins. more


  • Associate Director of the Physician-Scientist Pathway, Osler Residency Program
  • Associate Professor of Medicine

Departments / Divisions



  • MD; Northwestern University Feinberg School of Medicine (1998)


  • Internal Medicine; Northwestern University Feinberg School of Medicine (2002)


  • Pulmonary and Critical Care Medicine; Johns Hopkins University School of Medicine (2006)

Board Certifications

  • American Board of Internal Medicine (Critical Care Medicine) (2007)
  • American Board of Internal Medicine (Pulmonary Disease) (2006)

Research & Publications

Research Summary

Dr. Sidhaye’s research focuses on lung epithelial biology. As a principal investigator on several university and NIH sponsored grants, she has strong methodological training in bench and translational investigation. Using primary human differentiated lung cell culture models exposed to environmental particles involved in lung disease, including cigarette smoke, air pollution such as ambient/household air PM2.5, and aerosolized pollutants such as oils and dispersants, she has created in vitro exposure system to assess cellular and molecular dysregulation that leads to disease development.  Using these systems she can expose primary human cells to a variety of aerosolized particles while live imaging of cellular function including measuring cilary beat frequency and track intracellular proteins.  Her focus has been on molecular mechanisms by which critical epithelial proteins regulate cellular function, including cell-cell adhesive proteins such as E-cadherin, cytoskeletal proteins including actin-myosin and microtubules, as well as proteins involved in secretion and maintenance of airway surface liquid.


Lab Website: The Sidhaye Lab
Core Facility:

  • Microscopy/Confocal Imaging Core

Technology Expertise Keywords

Epithelial Biology; Cell-cell Adhesion; E-cadherin; Actin; Cytoskeleton; Ciliary Beat Frequency; Collective Motion

Contact for Research Inquiries

615 N. Wolfe St. E7622
Baltimore, MD 21205 map
Phone: 410-502-9293

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Academic Affiliations & Courses

Graduate Program Affiliation

Cell and Molecular Medicine

Environmental Health Sciences and Engineering

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