Una D McCann, M.D.

Headshot of Una D McCann
  • Associate Program Director JHBMC GCRC
  • Professor of Psychiatry and Behavioral Sciences

Languages: English, Spanish


Adult Psychiatry, Anxiety Disorders, Obsessive-Compulsive Disorder, Post Traumatic Stress, Psychiatry, Psychiatry and Behavioral Sciences ...read more

Research Interests

Amphetamine-induced Monoamine Neurotoxicity; Neurobiology of Anxiety Disorders ...read more

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Insurance Information

Main Phone

Outside of Maryland & Washington D.C.

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International Patients

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Johns Hopkins Bayview Medical Center

Appointment Phone: 410-550-1933
5500 Lombard Street
Baltimore, MD 21224
Johns Hopkins Bayview Medical Center - Google Maps

The Johns Hopkins Hospital (Main Entrance)

Appointment Phone: 410-955-5104
1800 Orleans St.
Sheikh Zayed Tower
Baltimore, MD 21287
The Johns Hopkins Hospital (Main Entrance) - Google Maps


Dr. Una McCann is a psychiatric specialist in Baltimore, caring for patients with anxiety disorders, obsessive-compulsive disorders and post-traumatic stress. Dr. McCann serves as Associate Program Director at the Johns Hopkins Bayview Medical Center Graduate Clinical Research Center. She is also Director of the Anxiety Disorders Program and Co-Director of the Center for Interdisciplinary Sleep Medicine and Research at Johns Hopkins School of Medicine.

Dr. McCann received her undergraduate degree in psychology from Princeton University. She earned her M.D. from Duke University School of Medicine. She completed her residency at Stanford University School of Medicine, where she also performed a fellowship in psychiatry. Dr. McCann joined the Johns Hopkins faculty in 1999.

Her research interests include amphetamine-induced monoamine neurotoxicity and the neurobiology of anxiety disorders.

Dr. McCann is a member of the Society for Neuroscience. She speaks both English and Spanish.

...read more


  • Associate Program Director JHBMC GCRC
  • Director, Anxiety Disorders Program
  • Professor of Psychiatry and Behavioral Sciences
  • Professor of Neurology

Departments / Divisions

Centers & Institutes



  • MD; Duke University School of Medicine (1984)


  • Psychiatry; Stanford University School of Medicine (1988)


  • Psychiatry; Stanford University School of Medicine (1988)

Board Certifications

  • American Board of Psychiatry And Neurology (Psychiatry) (1990)

Research & Publications

Research Summary

Dr. McCann’s two active areas of research are in amphetamine-induced monoamine neurotoxicity (i.e., MDMA, methamphetamine, ephedrine or amphetamine-induced monoaminergic neurotoxicity) and the neurobiology of anxiety disorders. Methods used in both research spheres include neuropharmacology, PET, MRI, fMRI, polysomnography, pharmacological challenge and neuropsychiatric assessment. Studies of amphetamine neurotoxicity also include preclinical studies using microarrays, cell culture, rodents and primates.

Core Facility:

  • Interdisciplinary Sleep, Research and Education (CISRE), Center for

Selected Publications

Williams MS, Ziegelstein RC, McCann UD, Gould NF, Ashvetiya T, Vaidya D. “Platelet Serotonin Signaling in Patients With Cardiovascular Disease and Comorbid Depression.” Psychosom Med. 2019 May;81(4):352-362

Garg A, Kapoor S, Goel M, Chopra S, Chopra M, Kapoor A, McCann UD, Behera C. “Functional Magnetic Resonance Imaging in Abstinent MDMA Users: A Review.” Curr Drug Abuse Rev. 2015;8(1):15-25

Mueller M, Yuan J, McCann UD, Hatzidimitriou G, Ricaurte GA. “Single oral doses of (±) 3,4-methylenedioxymethamphetamine ('Ecstasy') produce lasting serotonergic deficits in non-human primates: relationship to plasma drug and metabolite concentrations.” Int J Neuropsychopharmacol. 2013 May;16(4):791-801

Mueller M, Maldonado-Adrian C, Yuan J, McCann UD, Ricaurte GA. “Studies of (±) 3,4-methylenedioxymethamphetamine (MDMA) metabolism and disposition in rats and mice: relationship to neuroprotection and neurotoxicity profile.” J Pharmacol Exp Ther. 2013 Feb;344(2):479-88

Rao V, Mielke M, Xu X, Smith GS, McCann UD, Bergey A, Doshi V, Pham DL, Yousem D, Mori S. “Diffusion tensor imaging atlas-based analyses in major depression after mild traumatic brain injury.” J Neuropsychiatry Clin Neurosci. 2012 Summer;24(3):309-15

Academic Affiliations & Courses

Courses and Syllabi

  • Cognitive Behavior Therapy Training (Psychiatry PGY-III)
  • Anxiety Disorders Seminar
  • Psychiatry PGY-III Lecture Series
  • Medical Students Psychiatry Rotation
  • GIM Psychiatry Lecture Series
  • Introduction to Clinical Research Practicum
    2002 - 2003
  • Introduction to Clinical Research Course
    2001 - 2003

Activities & Honors


  • U.S. Army Commissioned Officers Award, 1995
  • Moos Fellowship for Clinical Research in Psychiatry, Stanford University, 1987 - 1988
  • Sigma Xi Award in Psychology, 1980
  • Howard Hughes Foundation Student Scholar, Peter Bent Brigham Hospital, 1980
  • Phi Beta Kappa and Sigma Xi Societies, 1980


  • Society for Neuroscience, 1988

Professional Activities

  • Editorial board member, Journal of Women’s Health and Gender Based Medicine
  • Editorial board member, Women in Medicine
  • Editorial board member, Addiciones
  • Editorial board member, Journal of Addiction
  • Editorial board member, Journal of Sleep Disorders: Treatment and Care
  • Editorial board member, WebmedCentral Plus
  • Editorial board member, Psychotherapy and Psychological Disorders
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