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Una D McCann, M.D.

Associate Program Director JHBMC GCRC
Professor of Psychiatry and Behavioral Sciences

Female

Languages: English, Spanish

Expertise

Adult Psychiatry, Anxiety Disorders, Obsessive-Compulsive Disorders, Post Traumatic Stress, Psychiatry, Psychiatry and Behavioral Sciences ...read more

Research Interests

Amphetamine-induced Monoamine Neurotoxicity; Neurobiology of Anxiety Disorders ...read more

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+1-410-502-7683

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Locations

Johns Hopkins Bayview Medical Center

Appointment Phone: 410-550-1933

5500 Lombard Street
Baltimore, MD 21224 map

The Johns Hopkins Hospital (Main Entrance)

Appointment Phone: 410-955-5104

1800 Orleans St.
Sheikh Zayed Tower
Baltimore, MD 21287 map

Background

Dr. Una McCann is a psychiatric specialist in Baltimore, caring for patients with anxiety disorders, obsessive-compulsive disorders and post-traumatic stress. Dr. McCann serves as Associate Program Director at the Johns Hopkins Bayview Medical Center Graduate Clinical Research Center. She is also Director of the Anxiety Disorders Program and Co-Director of the Center for Interdisciplinary Sleep Medicine and Research at Johns Hopkins School of Medicine.

Dr. McCann received her undergraduate degree in psychology from Princeton University. She earned her M.D. from Duke University School of Medicine. She completed her residency at Stanford University School of Medicine, where she also performed a fellowship in psychiatry. Dr. McCann joined the Johns Hopkins faculty in 1999.

Her research interests include amphetamine-induced monoamine neurotoxicity and the neurobiology of anxiety disorders.

Dr. McCann is a member of the Society for Neuroscience. She speaks both English and Spanish.

Titles

Associate Program Director JHBMC GCRC
Director, Anxiety Disorders Program
Professor of Psychiatry and Behavioral Sciences
Professor of Neurology

Departments / Divisions

Centers & Institutes

Education

Degrees

MD; Duke University School of Medicine (1984)

Residencies

Psychiatry; Stanford University School of Medicine (1988)

Fellowships

Psychiatry; Stanford University School of Medicine (1988)

Board Certifications

American Board of Psychiatry And Neurology (Psychiatry) (1990)

Research & Publications

Research Summary

Dr. McCann’s two active areas of research are in amphetamine-induced monoamine neurotoxicity (i.e., MDMA, methamphetamine, ephedrine or amphetamine-induced monoaminergic neurotoxicity) and the neurobiology of anxiety disorders. Methods used in both research spheres include neuropharmacology, PET, MRI, fMRI, polysomnography, pharmacological challenge and neuropsychiatric assessment. Studies of amphetamine neurotoxicity also include preclinical studies using microarrays, cell culture, rodents and primates.

Core Facility:

Interdisciplinary Sleep, Research and Education (CISRE), Center for

Selected Publications

Williams MS, Ziegelstein RC, McCann UD, Gould NF, Ashvetiya T, Vaidya D. “Platelet Serotonin Signaling in Patients With Cardiovascular Disease and Comorbid Depression.” Psychosom Med. 2019 May;81(4):352-362

Garg A, Kapoor S, Goel M, Chopra S, Chopra M, Kapoor A, McCann UD, Behera C. “Functional Magnetic Resonance Imaging in Abstinent MDMA Users: A Review.” Curr Drug Abuse Rev. 2015;8(1):15-25

Mueller M, Yuan J, McCann UD, Hatzidimitriou G, Ricaurte GA. “Single oral doses of (±) 3,4-methylenedioxymethamphetamine ('Ecstasy') produce lasting serotonergic deficits in non-human primates: relationship to plasma drug and metabolite concentrations.” Int J Neuropsychopharmacol. 2013 May;16(4):791-801

Mueller M, Maldonado-Adrian C, Yuan J, McCann UD, Ricaurte GA. “Studies of (±) 3,4-methylenedioxymethamphetamine (MDMA) metabolism and disposition in rats and mice: relationship to neuroprotection and neurotoxicity profile.” J Pharmacol Exp Ther. 2013 Feb;344(2):479-88

Rao V, Mielke M, Xu X, Smith GS, McCann UD, Bergey A, Doshi V, Pham DL, Yousem D, Mori S. “Diffusion tensor imaging atlas-based analyses in major depression after mild traumatic brain injury.” J Neuropsychiatry Clin Neurosci. 2012 Summer;24(3):309-15

Academic Affiliations & Courses

Courses and Syllabi

Cognitive Behavior Therapy Training (Psychiatry PGY-III)
2004
Anxiety Disorders Seminar
2004
Psychiatry PGY-III Lecture Series
2004
Medical Students Psychiatry Rotation
2004
GIM Psychiatry Lecture Series
2002
Introduction to Clinical Research Practicum
2002 - 2003
Introduction to Clinical Research Course
2001 - 2003

Activities & Honors

Honors

U.S. Army Commissioned Officers Award, 1995
Moos Fellowship for Clinical Research in Psychiatry, Stanford University, 1987 - 1988
Sigma Xi Award in Psychology, 1980
Howard Hughes Foundation Student Scholar, Peter Bent Brigham Hospital, 1980
Phi Beta Kappa and Sigma Xi Societies, 1980

Memberships

Society for Neuroscience, 1988

Professional Activities

Editorial board member, Journal of Women’s Health and Gender Based Medicine
Editorial board member, Women in Medicine
Editorial board member, Addiciones
Editorial board member, Journal of Addiction
Editorial board member, Journal of Sleep Disorders: Treatment and Care
Editorial board member, WebmedCentral Plus
Editorial board member, Psychotherapy and Psychological Disorders

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