Dr. Kickler's clinical research involves the study of pathologic blood clotting in variety of clinical disorders. Current research is in Pharmacogenomics of anti-coagulant agents, the role of platelet activation in coronary artery restenosis, atherosclerosis in HIV infection, and platelet activation in response to chronic cocaine ingestion.
He is also studying novel biomarkers of coagulation activation in patients with anti-phospholipid syndrome. Dr. Kickler directs the hematology laboratories and coagulation laboratories which are used to evaluate patients seen in the Hematology Clinic and Hemophilia Center.
He teaches laboratory hematology to hematology fellows and attends in the fellows clinic.
- Gluckman TJ, Segal JB, Fredde NL, Saland KE, Jani JT, Walenga JM, Prechel MM, Citro KM, Zidar DA, Fox E, Schulman SP, Kickler TS, Rade JJ. "Incidence of antiplatelet factor 4/heparin antibody induction in patients undergoing percutaneous coronary revascularization." Am J Cardiol. 2005 Mar 15;95(6):744-7.
- Slichter SJ, Davis K, Enright H, Braine H, Gernsheimer T, Kao KJ, Kickler T, Lee E, McFarland J, McCullough J, Rodey G, Schiffer CA, Woodson R. "Factors affecting posttransfusion platelet increments, platelet refractoriness, and platelet transfusion intervals in thrombocytopenic patients. Blood. 2005 May 15;105(10):4106-14. Epub 2005 Feb 3.
- Streiff MB, Segal J, Grossman SA, Kickler TS, Weir EG. “ABO blood group is a potent risk factor for venous thromboembolism in patients with malignant gliomas.” Cancer. 2004 Apr 15;100(8):1717-23.
- Ganesh K, Billings Y, Sharma K, Dayhoff J, Fales HM, Kickler TS, Nabel EG. “A novel MALDI-TOF mass spectroscopic proteomic technique for serumbiomarker assessment in venous thromboembolism.” Circulation. 2003;108(17):560.
- Brotman DJ, Segal JB, Jani JT, Petty BG, Kickler TS. “Limitations of D-dimer testing in unselected inpatients with suspected venous thromboembolism.” Am J Med. 2003 Mar;114(4):276-82.
Takemoto, C.M, Jani J, Streiff Mj, Chen J, Kickler, T. Activated partial thromboplastin time and anti-xa measurements in heparin monitoring: biochemical basis for discordance. Am J Clin Pathol. 139:450-6, 2013.
Kakououse N, Kickler T, Rade J. J Thromb Haemost 11(10) 1814-22, 2013 . Hematocrit alters Verify P2Y12 assay results independently of intrinsic platelet reactivity and clopridogrel responsiveness.
DeFillipis AP, Oloyede OS, Guallar E, Blumenthal RS, Kickler TS, Rade JJ. Thromboxane generation in absence of Cox-1 activity in patients with myocardial infarction. Circulation 77(11) 2786-93, 2014.
Lai H, Stitzer M, Treisman G, Moore R, Brinker J, Gerstenblith G, Kickler TS, Li J, Chen S, Fishman E, Lai S. Cocaine abstinence and reduced use associated with lowered marker of endothelial dysfunction in African Americans, J Addict Med. 2015 Jul 7.
Streiff MB, Ye X, Kickler TS, Desideri S, Jani J, Fisher J, Grossman SA. A prospective multicenter study of venous thromboembolism in patients with newly diagnosed high grade glioma, hazard rates and risk factors. J Neurooncol. 2015 Jun 23.
Gavriilaki E, Yuan X, Ye Z, Ambinder AJ, Shanbhag SP, Streiff MB, Kickler TS Brodsky RA Modified Ham test for atypical hemolytic uremic syndrome. .Blood. 2015 Jun 4;125(23):3637-46.