Background
Titles
- Assistant Professor of Neurology
Departments / Divisions
- Neurology - Institute for Cell Engineering
- Assistant Professor of Neurology
Tae-In Kam, Ph.D.
Tae-In Kam, Ph.D.
Education
Degrees
- B.S.; Seoul National University (Korea) (2006)
- Ph.D.; Seoul National University (Korea) (2013)
Research & Publications
Research Summary
Molecular mechanisms of neuronal cell death in neurodegenerative diseases
Selected Publications
Kam TI*, Mao X*, Park H*, Chou SC, Karuppagounder SS, Umanah GE, Yun SP, Brahmarchari S, Panicker N, Chen R, Andrabi SA, Qi C, Poirier GG, Pletnikova O, Troncoso JC, Bekris LM, Leverenz JB, Pantelyat A, Ko HS, Rosenthal LS, Dawson TM#, Dawson VL#. Poly (ADP-ribose) drives pathologic a-synuclein neurodegeneration in Parkinson’s disease. Science 362(6414). pii: eaat8407 (2018)(*equal contribution)
Gwon Y*, Kam TI*, Kim SH, Song S, Park H, Lim B, Lee H, Lee W, Jo DG, Jung YK. TOM1 regulates neuronal accumulation of amyloid-β oligomers by FcγRIIb2 variant in Alzheimer’s disease. Journal of Neuroscience pii:1996-17 (2018) (*equal contribution)
Yun SP*, Kam TI*, Panicker N, Kim S, Oh Y, Park JS, Kwon SH, Park YJ, Karuppagounder SS, Park H, Kim S, Oh N, Kim NA, Lee S, Brahmachari S, Mao X, Lee JH, Kumar M, An D, Kang SU, Lee Y, Lee KC, Na DH, Kim D, Lee SH, Roschke V, Liddelow SA, Mari Z, Barres BA, Dawson VL, Lee S#, Dawson TM#, Ko HS#. Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease. Nature Medicine 24(7), 931-938 (2018) (*equal contribution)
Kam TI*, Park H*, Gwon Y*, Song S, Kim SH, Moon SW, Jo DG, Jung YK. FcγRIIb-SHIP2 axis links Aβ to tau pathology by disrupting phosphoinositide metabolism in Alzheimer's disease model. Elife pii:e18691 (2016) (*equal contribution)
Kam TI*, Song S*, Gwon Y, ParkH, Yan JJ, ImI, Choi JW, Choi TY, KimJ, SongDK, TakaiT, KimYC, Kim KS, Choi SY, Choi S, Klein WL, Yuan J, and Jung YK. FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer’s disease. Journal of Clinical Investigation 123(7), 2791-2802 (2013) (*equal contribution)
Patents
MIF Inhibitors And Methods of Use Thereof, Ted Dawson, Valina Dawson, Yingfei Wang, Jun Liu, Hanjing Peng, Hyejin Park, Tae-In Kam
Patent # PCT/US2017/049778 |
Detection of Par in The CSF Patients With Parkinson’s Disease, Ted Dawson, Valina Dawson, Tae-In Kam, Liana Rosenthal, Shaida Andrabi
Patent # PCT/US2018/035614 |
Activities & Honors
Honors
- Research Support scholarship, Seoul National University, Seoul, Korea, 2007
- Seoul Fellowship, Seoul Metropolitan Government, Seoul, Korea, 2008
- Best poster award, The 22nd Biennial Meeting of the ISN/APSN Joint Meeting, 2009
- Best poster award, The 5th Annual Meeting of Korean Society for Neurodegenerative Disease (KSND), Korea, 2011
- Best poster award, The 23rd Korean Society for Molecular and Cellular Biology, Korea, 2012
- Best poster award, The 6th Annual Meeting of Korean Society for Neurodegenerative Disease (KSND), Korea, 2012
- Excellence in Research award, Association of Korean Neuroscientists, San Diego, 2018
- Helen B. Taussig Young Investigator Award, Johns Hopkins University, Baltimore, 2019
Memberships
- Society for Neuroscience (SfN), 2015
- Baltimore Life Science Association (BLSA), 2014
- Alzheimer's Association International Conference (AAIC), 2008 - 2013
Videos & Media
Lectures and Presentations
-
A neurotoxic receptor in Alzheimer’s disease
Invited speaker, The 3th Annual Meeting of Korean Society for Neurodegenerative Disease (KSND), Korea (12/01/2009) -
FcγRIIb mediates Aβ neurotoxicity in Alzheimer’s disease
Invited speaker, The 8th Protein Kinesis and Disease Symposium, Korea (07/01/2010) -
FcγRIIb-SHIP2 axis links Aβ to tau pathology by disrupting phosphoinositide metabolism in Alzheimer's disease model
Invited speaker, The Korean Association for Geriatric Psychiatry (KAGP) Meeting, Seoul (11/01/2010) -
Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease.
Invited speaker, JPB foundation Joint Consortia Meeting, New York, NY (02/20/2018) -
Poly (ADP-ribose) drives pathologic a-synuclein neurodegeneration
Oral presentation, The PARP Family and ADP-ribosylation Meeting, Cold Spring Harbor, NY (04/05/2018) -
PAR-kinson’s disease?: Role of poly (ADP-rbiose) in Parkinson’s disease
Invited speaker, Johns Hopkins University Neuroscience research seminar, Baltimore, MD (10/02/2018) -
Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease
Oral presentation, Society for Neuroscience meeting, San Diego, CA (11/05/2018)
Recent News Articles and Media Coverage
Road to Cell Death More Clearly Identified for Parkinson’s Disease, Johns Hopkins Medicine (November 02, 2018)
Experimental drug stops Parkinson's disease progression and symptoms in mice, Hub (July 3, 2018)