- Associate Professor of Oncology
Departments / Divisions
- Oncology - Genitourinary Cancer Disease
Sushant Krishna Kachhap, Ph.D.
Prostate Cancer Biology
My research focuses on prostate cancer biology and deciphering molecular mechanisms responsible for metastasis and DNA repair in prostate cancer with the goal to target these pathways. Our work has targeted androgen signaling, DNA repair, and metastatic pathways with novel therapeutics and combined it with existing therapeutic modalities to achieve a better therapeutic index. We have also deciphered the molecular function of NDRG1, a prostate metastasis suppressor that is involved in vesicular transport. Our work continues to identify novel molecular targets for prostate cancer therapy.
Molecular and Cellular Biology of Prostate and Breast Cancer
Mark C. Markowski, Eugene Shenderov, Mario A. Eisenberger, Sushant Kachhap, Samuel R. Denmeade, Emmanuel S. Antonarakis (2020). Extreme Responses to Immune Checkpoint Blockade Following Bipolar Androgen Therapy and Enzalutamide in Patients with Metastatic Castration Resistant Prostate Cancer. The Prostate 2020;80(5):407-411
Hao Geng, Changhui Xue, Janet Mendonca, Xiao-Xin Sun, Qiong Liu , Patrick N. Reardon , Yingxiao Chen, Kendrick Qian , Vivian Hua , Alice Chen , Freddy Pan , Julia Yuan , Sang Dang , Tomasz M. Beer, Mu-Shui Dai, Sushant K. Kachhap, David Z. Qian., (2018). Interplay between hypoxia and androgen controls a metabolic switch conferring resistance to androgen/AR-targeted therapy. Nature Communications. 26;9 (1):4972
Sharma, A., Mendonca, J., Ying, J., Kim, H. S., Verdone, J. E., Zarif, J. C., Carducci, M., Hammers, H., Pienta, K. J., and Kachhap, S. (2017) The prostate metastasis suppressor gene NDRG1 differentially regulates cell motility and invasion. Mol Oncol 11, 655-669
Teply, B.A., Kachhap, S., Eisenberger, M.A., Denmeade, S.R., 2017. Extreme Response to High-dose Testosterone in BRCA2- and ATM-mutated Prostate Cancer. Eur Urol 71, 499
Croessmann, S., Wong, H. Y., Zabransky, D. J., Chu, D., Mendonca, J., Sharma, A., Mohseni, M., Rosen, D. M., Scharpf, R. B., Cidado, J., Cochran, R. L., Parsons, H. A., Dalton, W. B., Erlanger, B., Button, B., Cravero, K., Kyker-Snowman, K., Beaver, J. A., Kachhap, S., Hurley, P. J., Lauring, J., and Park, B. H. (2015) NDRG1 links p53 with proliferation-mediated centrosome homeostasis and genome stability. Proc Natl Acad Sci U S A 112, 11583-11588