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Sudath S.H. Hapuarachchige, M.S., Ph.D.

Headshot of Sudath S.H. Hapuarachchige
  • Assistant Professor of Radiology and Radiological Science

Research Interests

Development of image-guided and targeted drug delivery systems as theranostics for cancer therapy; Development of novel chemical strategies for smart-release of drugs ...read more

Background

Sudath Hapuarachchige, Ph.D. is an Assistant Professor of Radiology and Radiological Science in Johns Hopkins University School of Medicine. Dr. Hapuarachchige received his Bachelor of Science (B.Sc.) degree from the Department of Chemistry, University of Colombo and accomplished his MS and Ph.D. in synthetic organic chemistry in the Department of Chemistry and Biochemistry, New Mexico State University, USA. Dr. Hapuarachchige's research is focused on the development of (a) image-guided drug delivery systems for theranostic applications in cancer therapy, (b) novel chemical strategies for smart-release of drugs, and (c) antibody-drug conjugates for efficacious drug delivery. Dr. Hapuarachchige is the recipient of Alfred Blalock Young Investigator Award in 2015 and Outstanding Young Faculty in Research Award in 2020 from the Johns Hopkins University School of Medicine.

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Titles

  • Assistant Professor of Radiology and Radiological Science
  • Assistant Professor of Oncology

Departments / Divisions

Centers & Institutes

Education

Degrees

  • M.S.; New Mexico State University (New Mexico) (2006)
  • Ph.D.; New Mexico State University (New Mexico) (2010)
  • B.Sc.; University of Colombo (Sri Lanka) (2001)

Research & Publications

Technology Expertise Keywords

Targeted drug delivery in cancer, Image-guided drug delivery, Theranostics, Controlled-release of drugs

Clinical Trials

Learn more about clinical trials at Johns Hopkins Medicine.

Selected Publications

Huang CT, Guo X, Bařinka C, Lupold SE, Pomper MG, Gabrielson K, Raman V, Artemov D, Hapuarachchige S. Development of 5D3-DM1: A novel anti-prostate-specific membrane antigen antibody-drug conjugate for PSMA-positive prostate cancer therapy. Mol Pharm. 2020; 17(9): 3392-3402

Hapuarachchige S, Huang CT, Donnelly MC, Bařinka C, Lupold SE, Pomper MG, Artemov D. Cellular Delivery of Bioorthogonal pretargeting therapeutics in PSMA-positive prostate cancer. Mol Pharm. 2020; 17(1): 98-108

Hapuarachchige S, Kato Y, Artemov D. Bioorthogonal two-component drug delivery in HER2(+) breast cancer mouse models. Sci Rep. 2016; 6: 24298

Hapuarachchige S, Zhu W, Kato Y, Artemov D. Bioorthogonal, two-component delivery systems based on antibody and drug-loaded nanocarriers for enhanced internalization of nanotherapeutics. Biomaterials. 2014; 35(7): 2346-2354

Hapuarachchige S, Montaño G, Ramesh C, Rodriguez D, Henson LH, Williams CC, Kadavakkollu S, Johnson DL, Shuster CB, Arterburn JB. Design and synthesis of a new class of membrane-permeable triazaborolopyridinium fluorescent probes. J Am Chem Soc. 2011; 133(17): 6780-6790

Contact for Research Inquiries

Johns Hopkins University School of Medicine
720 Rutland Avenue
Traylor 217-F
Baltimore, MD 21205 map

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Activities & Honors

Honors

  • Honors graduate award for outstanding academic achievement, NMSU, 2006
  • ACS Travel Award, American Chemical Society, 2009
  • Honors graduate award for outstanding academic achievement, NMSU, 2010
  • Educational Trainee Award, ISMRM, 2012
  • Faculty scholars in cancer research, AACR, 2013
  • Educational Trainee Award, ISMRM, 2013
  • Summa cum laude award (Targeted drug delivery), ISMRM, 2013
  • Ruth D. Vogel Professional Development Award, JHU, 2014
  • Educational Trainee Award, ISMRM, 2015
  • Magna cum Laude Award (Molecular Imaging), ISMRM, 2015
  • Alfred Blalock Young Investigator Award, JHU, 2015
  • Best Poster in Radiology Research, JHU, 2017
  • Best Research Image, JHU, 2018
  • Best Poster in Radiology Research, JHU, 2018
  • Outstanding Young Faculty in Research, Johns Hopkins Medicine, Radiology, 2020
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