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Stuart Grossman, M.D.

Headshot of Stuart Grossman
  • Co-Director, Brain Cancer Research Program, Sidney Kimmel Cancer Center
  • Professor of Oncology


Brain Tumors, Medical Oncology, Neuro-Oncology, Pain Management more

Research Interests

brain cancer; cancer pain

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Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

Appointment Phone: 410-955-8964
401 N. Broadway
Baltimore, MD 21231 map
Phone: 410-955-8837 | Fax: 410-614-9335


Stuart Grossman, M.D., professor of oncology at the Johns Hopkins Kimmel Cancer Center, is co-Leader of the Brain Cancer Program and has directed the clinical and research neuro-oncology efforts at Johns Hopkins since 1981. He has served as Principal Investigator and Director of the Central Operations office of the National Cancer Institute-funded phase I/II brain tumor consortia (New Approaches to Brain Tumor Therapy CNS Consortium and the Adult Brain Tumor Consortium) for the past 22 years. He has led many phase I, II, and III institutional and cooperative group translational and clinical brain cancer research projects. 

Dr. Grossman's expertise is in brain cancers, translational and clinical research, and directing large, multicenter, multidisciplinary clinical trial groups and training programs.

Dr. Grossman was an intern and resident at Strong Memorial Hospital in Rochester, NY, and a fellow at the Johns Hopkins University School of Medicine. He received his M.D. from the University of Rochester. more


  • Co-Director, Brain Cancer Research Program, Sidney Kimmel Cancer Center
  • Professor of Oncology
  • Professor of Medicine
  • Professor of Neurosurgery

Departments / Divisions

Centers & Institutes



  • MD; University of Rochester School of Medicine and Dentistry (1973)


  • Internal Medicine; Strong Memorial Hospital of the University of Rochester (1976)


  • Medical Oncology; Johns Hopkins University School of Medicine (1981)

Board Certifications

  • American Board of Internal Medicine (Internal Medicine) (1976)
  • American Board of Internal Medicine (Medical Oncology) (1983)

Research & Publications

Clinical Trial Keywords

cancer pain; brain tumors

Selected Publications

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Blakeley, J.O.; Grossman, S.A. Management of pineal region tumors. Current Treatment Options in Oncology. 2006 Nov;7(6):505-516.

Chu, L.C.; Eberhart, C.G.; Grossman, S.A.; Herman, J.G. Epigenetic silencing of multiple genes in primary CNS lymphoma. Int J Cancer. 2006 Nov 15;119(10):2487-2491.

Gerber, D.E.; Grossman, S.A. Does decompressive surgery improve outcome in patients with metastatic epidural spinal-cord compression? Nature clinical practiceNeurology. 2006 Jan;2(1):10-11.

Gerber, D.E.; Grossman, S.A.; Streiff, M.B. Management of venous thromboembolism in patients with primary and metastatic brain tumors. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2006 Mar 10;24(8):1310-1318.

Grossman, S.A.; Carson, K.A.; Batchelor, T.T.; Lesser, G.; Mikkelsen, T.; Alavi, J.B.; Phuphanich, S.; Hammour, T.; Fisher, J.D.; Supko, J.G. The effect of enzyme-inducing antiseizure drugs on the pharmacokinetics and tolerability of procarbazine hydrochloride. Clinical Cancer Res:An Official Journal of the American Association for Cancer Res. 2006 Sep 1;12(17):5174-5181.

Mathew, B.S.; Carson, K.A.; Grossman, S.A. Initial response to glucocorticoids. Cancer. 2006 Jan 15;106(2):383-387.

Weaver, K.D.; Grossman, S.A.; Herman, J.G. Methylated tumor-specific DNA as a plasma biomarker in patients with glioma. Cancer investigation. 2006 Feb;24(1):35-40.

Carson, K.A.; Grossman, S.A.; Fisher, J.D.; Shaw, E.G. Prognostic factors for survival in adult patients with recurrent glioma enrolled onto the new approaches to brain tumor therapy CNS consortium phase I and II clinical trials. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2007 Jun 20;25(18):2601-2606.

Gerber, D.E., T. Chan, S. A. Grossman, L. Kleinberg Intracranial Hemorrhage during GliaSite RTS manipulation in an anticoagulated patient. Journal Radiotherapy in Practice. 2007;6 (1):53-57.

Gerber, D.E.; Grossman, S.A.; Batchelor, T.; Ye, X. Calculated versus measured creatinine clearance for dosing methotrexate in the treatment of primary central nervous system lymphoma. Cancer chemotherapy and pharmacology. 2007 May;59(6):817-823.

Gerber, D.E.; Grossman, S.A.; Zeltzman, M.; Parisi, M.A.; Kleinberg, L. The impact of thrombocytopenia from temozolomide and radiation in newly diagnosed adults with high-grade gliomas. Neuro-oncology. 2007 Jan;9(1):47-52.

Gerber, D.E.; Segal, J.B.; Salhotra, A.; Olivi, A.; Grossman, S.A.; Streiff, M.B. Venous thromboembolism occurs infrequently in meningioma patients receiving combined modality prophylaxis. Cancer. 2007 Jan 15;109(2):300-305.

Kelloff, G.J.; Sullivan, D.C.; Baker, H.; Clarke, L.P.; Nordstrom, R.; Tatum, J.L.; Dorfman, G.S.; Jacobs, P.; Berg, C.D.; Pomper, M.G.; Birrer, M.J.; Tempero, M.; Higley, H.R.; Petty, B.G.; Sigman, C.C.; Maley, C.; Sharma, P.; Wax, A.; Ginsberg, G.G.; Dannenberg, A.J.; Hawk, E.T.; Messing, E.M.; Grossman, H.B.; Harisinghani, M.; Bigio, I.J.; Griebel, D.; Henson, D.E.; Fabian, C.J.; Ferrara, K.; Fantini, S.; Schnall, M.D.; Zujewski, J.A.; Hayes, W.; Klein, E.A.; DeMarzo, A.; Ocak, I.; Ketterling, J.A.; Tempany, C.; Shtern, F.; Parnes, H.L.; Gomez, J.; Srivastava, S.; Szabo, E.; Lam, S.; Seibel, E.J.; Massion, P.; McLennan, G.; Cleary, K.; Suh, R.; Burt, R.W.; Pfeiffer, R.M.; Hoffman, J.M.; Roy, H.K.; Wang, T.; Limburg, P.J.; El-Deiry, W.S.; Papadimitrakopoulou, V.; Hittelman, W.N.; MacAulay, C.; Veltri, R.W.; Solomon, D.; Jeronimo, J.; Richards-Kortum, R.; Johnson, K.A.; Viner, J.L.; Stratton, S.P.; Rajadhyaksha, M.; Dhawan, A. Workshop on imaging science development for cancer prevention and preemption. Cancer Biomark. 2007;3(1):1-33.

Mikkelsen, T.; Lush, R.; Grossman, S.A.; Carson, K.A.; Fisher, J.D.; Alavi, J.B.; Rosenfeld, S. Phase II clinical and pharmacologic study of radiation therapy and carboxyamido-triazole (CAI) in adults with newly diagnosed glioblastoma multiforme. Investigational new drugs. 2007 Jun;25(3):259-263.

Nabors, L.B.; Mikkelsen, T.; Rosenfeld, S.S.; Hochberg, F.; Akella, N.S.; Fisher, J.D.; Cloud, G.A.; Zhang, Y.; Carson, K.; Wittemer, S.M.; Colevas, A.D.; Grossman, S.A. Phase I and correlative biology study of cilengitide in patients with recurrent malignant glioma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2007 May 1;25(13):1651-1657.

Peng, T.; Blakeley, J.; Cingolani, E.; Griffiths, E.; Grossman, S.A. Herpes simplex encephalitis in a patient with recurrent pituitary adenoma receiving radiation therapy. American journal of clinical oncology. 2007 Dec;30(6):664-665.

Weingart, J.; Grossman, S.A.; Carson, K.A.; Fisher, J.D.; Delaney, S.M.; Rosenblum, M.L.; Olivi, A.; Judy, K.; Tatter, S.B.; Dolan, M.E. Phase I trial of polifeprosan 20 with carmustine implant plus continuous infusion of intravenous O6-benzylguanine in adults with recurrent malignant glioma: new approaches to brain tumor therapy CNS consortium trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2007 Feb 1;25(4):399-404.

Blakeley, J.; Grossman, S. Anaplastic oligodendroglioma. Current treatment options in neurology. 2008 Jul;10(4):295-307.

Brem, S.S.; Bierman, P.J.; Black, P.; Brem, H.; Chamberlain, M.C.; Chiocca, E.A.; DeAngelis, L.M.; Fenstermaker, R.A.; Friedman, A.; Gilbert, M.R.; Glass, J.; Grossman, S.A.; Heimberger, A.B.; Junck, L.; Linette, G.P.; Loeffler, J.J.; Maor, M.H.; Moots, P.; Mrugala, M.; Nabors, L.B.; Newton, H.B.; Olivi, A.; Portnow, J.; Prados, M.; Raizer, J.J.; Shrieve, D.C.; Sills, A.K., Jr. Central nervous system cancers. Journal of the National Comprehensive Cancer Network : JNCCN. 2008 May;6(5):456-504.

Chen, H.; Shah, A.S.; Girgis, R.E.; Grossman, S.A. Transmission of glioblastoma multiforme after bilateral lung transplantation. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2008 Jul 1;26(19):3284-3285.

Easter, J.S.; Grossman, S.A.; Woodruff, M.M.; Rosen, C.L. When the rules do not work: head injury without loss of consciousness. The Journal of emergency medicine. 2008 Jul;35(1):77-80.

Gerstner, E.R.; Carson, K.A.; Grossman, S.A.; Batchelor, T.T. Long-term outcome in PCNSL patients treated with high-dose methotrexate and deferred radiation. Neurology. 2008 Jan 29;70(5):401-402.

Grossman, S.A.; Carson, K.A.; Phuphanich, S.; Batchelor, T.; Peereboom, D.; Nabors, L.B.; Lesser, G.; Hausheer, F.; Supko, J.G.; New Approaches to Brain Tumor Therapy, C.N.S.C. Phase I and pharmacokinetic study of karenitecin in patients with recurrent malignant gliomas. Neuro-oncology. 2008 Aug;10(4):608-616.

Grossman, S.A.; Olson, J.; Batchelor, T.; Peereboom, D.; Lesser, G.; Desideri, S.; Ye, X.; Hammour, T.; Supko, J.G.; New Approaches to Brain Tumor Therapy, C.N.S.C. Effect of phenytoin on celecoxib pharmacokinetics in patients with glioblastoma. Neuro-oncology. 2008 Apr;10(2):190-198.

Blakeley, J.O.; Olson, J.; Grossman, S.A.; He, X.; Weingart, J.; Supko, J.G.; New Approaches to Brain Tumor Therapy, C. Effect of blood brain barrier permeability in recurrent high grade gliomas on the intratumoral pharmacokinetics of methotrexate: a microdialysis study. Journal of neuro-oncology. 2009 Jan;91(1):51-58.

De Jesus, A.; Grossman, S.A.; Paun, O. Cytomegalovirus associated colonic pseudotumor: a consequence of iatrogenic immunosuppression in a patient with primary brain tumor receiving radiation and temozolomide. Journal of neuro-oncology. 2009 Sep;94(3):445-448.

Grossman, S.A.; Ye, X.; Chamberlain, M.; Mikkelsen, T.; Batchelor, T.; Desideri, S.; Piantadosi, S.; Fisher, J.; Fine, H.A. Talampanel with standard radiation and temozolomide in patients with newly diagnosed glioblastoma: a multicenter phase II trial. J Clin Oncol. 2009 Sep 1;27(25):4155-4161.

Holdhoff, M.; Supko, J.G.; Gallia, G.L.; Hann, C.L.; Bonekamp, D.; Ye, X.; Cao, B.; Olivi, A.; Grossman, S.A. Intratumoral concentrations of imatinib after oral administration in patients with glioblastoma multiforme. J Neurooncol. 2009 Sep 19;97(2):241-250.

McGirt, M.J.; Than, K.D.; Weingart, J.D.; Chaichana, K.L.; Attenello, F.J.; Olivi, A.; Laterra, J.; Kleinberg, L.R.; Grossman, S.A.; Brem, H.; Quinones-Hinojosa, A. Gliadel (BCNU) wafer plus concomitant temozolomide therapy after primary resection of glioblastoma multiforme. Journal of neurosurgery. 2009 Mar;110(3):583-588.

Grossman, R.; Mukherjee, D.; Chang, D.C.; Purtell, M.; Lim, M.; Brem, H.; Quinones-Hinojosa, A. Predictors of Inpatient Death and Complications among Postoperative Elderly Patients with Metastatic Brain Tumors. Annals of surgical oncology. 2010 (Journal Article).

Grossman, S.A.; Ye, X.; Piantadosi, S.; Desideri, S.; Nabors, L.B.; Rosenfeld, M.; Fisher, J.; Consortium, N.C. Survival of patients with newly diagnosed glioblastoma treated with radiation and temozolomide in research studies in the United States. Clinical cancer research : an official journal of the American Association for Cancer Research. 2010;16(8):2443-2449.

Holdhoff, M.; Supko, J.G.; Gallia, G.L.; Hann, C.L.; Bonekamp, D.; Ye, X.; Cao, B.; Olivi, A.; Grossman, S.A. Intratumoral concentrations of imatinib after oral administration in patients with glioblastoma multiforme. J Neurooncol. 2010 Apr;97(2):241-245.

Peereboom, D.M.; Supko, J.G.; Carson, K.A.; Batchelor, T.; Phuphanich, S.; Lesser, G.; Mikkelsen, T.; Fisher, J.; Desideri, S.; He, X.; Grossman, S.A.; New Approaches to Brain Tumor Therapy, C. A phase I/II trial and pharmacokinetic study of ixabepilone in adult patients with recurrent high-grade gliomas. Journal of neuro-oncology. 2010;100(2):261-268.

Phuphanich, S.; Supko, J.G.; Carson, K.A.; Grossman, S.A.; Burt Nabors, L.; Mikkelsen, T.; Lesser, G.; Rosenfeld, S.; Desideri, S.; Olson, J.J. Phase 1 clinical trial of bortezomib in adults with recurrent malignant glioma. Journal of neuro-oncology. 2010;100(1):95-103.

Rosenfeld, M.R.; Chamberlain, M.C.; Grossman, S.A.; Peereboom, D.M.; Lesser, G.J.; Batchelor, T.T.; Desideri, S.; Salazar, A.M.; Ye, X. A multi-institution phase II study of poly-ICLC and radiotherapy with concurrent and adjuvant temozolomide in adults with newly diagnosed glioblastoma. Neuro-oncology. 2010;12(10):1071-1077.

Zhou, J.; Tryggestad, E.; Wen, Z.; Lal, B.; Zhou, T.; Grossman, R.; Wang, S.; Yan, K.; Fu, D.X.; Ford, E.; Tyler, B.; Blakeley, J.; Laterra, J.; van Zijl, P.C. Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides. Nat Med. 2011 Jan;17(1):130-134.

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