Stephen Carl Mathai, M.D., M.H.S.

Headshot of Stephen Carl Mathai
  • Director, Inpatient Pulmonary Service, Johns Hopkins Hospital
  • Associate Professor of Medicine


Pulmonary and Critical Care Medicine

Research Interests

Scleroderma-associated pulmonary hypertension; Idiopathic pulmonary fibrosis; Pulmonary complications of connective tissue disease; Pulmonary hypertension more

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Outside of Maryland & Washington D.C.

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The Johns Hopkins Hospital

Appointment Phone: 410-550-5864
1830 E. Monument Street
1830 Building 5th Floor Pulmonary
Baltimore, MD 21287
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Johns Hopkins Outpatient Center (now called Levi Watkins, Jr., M.D., Outpatient Center)

Appointment Phone: 410-550-5864
601 N. Caroline St.
Baltimore, MD 21287
Johns Hopkins Outpatient Center (now called Levi Watkins, Jr., M.D., Outpatient Center) - Google Maps

Johns Hopkins Bayview Medical Center

Appointment Phone: 410-550-5864
4940 Eastern Avenue
Baltimore, MD 21224
Phone: 410-955-3467
Johns Hopkins Bayview Medical Center - Google Maps


Stephen C. Mathai, MD, MHS is an Associate Professor of Medicine and part of the Johns Hopkins Pulmonary Hypertension Program. Dr. Mathai received his undergraduate degree from Rutgers College and medical degree from Jefferson Medical College. He pursued residency training in Internal Medicine at Thomas Jefferson University Hospital, where he also served as Chief Medical Resident. Dr. Mathai came to Johns Hopkins for fellowship training in Pulmonary and Critical Care Medicine. During his 5-year fellowship, he obtained a Masters of Health Science degree from the Johns Hopkins Bloomberg School of Public Health and successfully competed for an individual Ruth L. Kirschstein National Research Service Award. Subsequently, he received a K23 award for his research in pulmonary vascular disease in scleroderma. He currently serves as Co-Principal Investigator for the Johns Hopkins PVDOMICS program supported by the NIH and is principal investigator for a clinical trial of therapy for scleroderma associated pulmonary hypertension supported by the Department of Defense Peer Reviewed Medical Research Program. He is also the Co-Director of the Ann Dana Kusch Multidisciplinary Program for Interstitial Lung Disease and Pulmonary Hypertension.

Dr. Mathai has been active in numerous committees and holds several leadership positions in academic societies. He is the current chair of the Pulmonary Vascular Disease Network for the American College of Chest Physicians and has served on the steering committee for this organization for the past 4 years. He has served on several committees for the Pulmonary Circulation Assembly of the American Thoracic Society, including the Program Committee and Nominations Committee. He has organized symposia and delivered presentations related to pulmonary hypertension at numerous international meetings. He is the author of more than 100 publications and has given invited research lectures nationally and internationally.  Dr. Mathai is also an active member of patient advocacy organizations. Currently, he is a member of the Scientific Leadership Council of the Pulmonary Hypertension Association where he serves as national chairperson of the Preceptorship Program Planning Committee. He is also a member of the Rare Disease Advisory Panel for the Patient Centered Outcomes Research Institute. Dr. Mathai also serves as the faculty leader of the inpatient pulmonary service, the Carol Johns Service, where he is responsible for the education of the internal medicine housestaff and pulmonary fellows. He has also received the Frederick L. Brancati Award for mentorship from the Department of Medicine at Johns Hopkins. more


  • Director, Inpatient Pulmonary Service, Johns Hopkins Hospital
  • Co-Director, Ann Dana Kusch Multidisciplinary Program for Interstitial Lung Disease and Pulmonary Hypertension Research
  • Associate Professor of Medicine

Departments / Divisions

Centers & Institutes



  • MD; Sidney Kimmel Medical College of Thomas Jefferson University (1999)


  • Medicine; Thomas Jefferson University Hospital (2003)


  • Pulmonary and Critical Care Medicine; Johns Hopkins University School of Medicine (2008)

Board Certifications

  • American Board of Internal Medicine (Critical Care Medicine) (2010)
  • American Board of Internal Medicine (Pulmonary Disease) (2009)

Research & Publications

Selected Publications

View all on PubMed

Chin K, Mathai SC. “Exercise echocardiography in connective tissue disease.” J Am Coll Cardiol. 2015 Jul 28;66(4):385-7. doi: 10.1016/j.jacc.2015.05.038. 

Kelemen BW, Mathai SC, Tedford RJ, Damico RL, Corona-Villalobos C, Kolb TM, Chaisson NF, Harris TH, Zimmerman SL, Kamel IR, Kass DA, Hassoun PM. “Right ventricular remodeling in idiopathic and scleroderma-associated pulmonary arterial hypertension: two distinct phenotypes.” Pulm Circ. 2015 Jun;5(2):327-34. doi: 10.1086/680356.

Bourji KI, Khair RM, Damico RL, Kolb TM, Mathai SC, Hassoun PM. “Vascular receptor autoantibodies in pulmonary arterial hypertension.” Am J Respir Crit Care Med. 2015 Mar 1;191(5):602. doi: 10.1164/rccm.201412-2267LE.

Matura LA, Ventetuolo CE, Palevsky HI, Lederer DJ, Horn EM, Mathai SC, Pinder D, Archer-Chicko C, Bagiella E, Roberts KE, Tracy RP, Hassoun PM, Girgis RE, Kawut SM. “Interleukin-6 and tumor necrosis factor-α are associated with quality of life-related symptoms in pulmonary arterial hypertension.” Ann Am Thorac Soc. 2015 Mar;12(3):370-5. doi: 10.1513/AnnalsATS.201410-463OC. PMID: 25615959

Damico R, Kolb TM, Valera L, Wang L, Housten T, Tedford RJ, Kass DA, Rafaels N, Gao L, Barnes KC, Benza RL, Rand JL, Hamid R, Loyd JE, Robbins IM, Hemnes AR, Chung WK, Austin ED, Drummond MB, Mathai SC, Hassoun PM. “Serum endostatin is a genetically determined predictor of survival in pulmonary arterial hypertension.” Am J Respir Crit Care Med. 2015 Jan 15;191(2):208-18. doi: 10.1164/rccm.201409-1742OC.

Dezube R, Terry P, Akulian J, Mathai SC, Boyle M, Khasab T, Yarmus L. Chronic expanding hematoma of the lung. Am J Respir Crit Care Med. 2013 Dec 1;188(11):e71. doi: 10.1164/rccm.201304-0723IM. No abstract available. PMID: 24289786

Bonner N, Abetz L, Meunier J, Sikirica M, Mathai SC. Development and validation of the living with pulmonary hypertension questionnaire in pulmonary arterial hypertension patients. Health Qual Life Outcomes. 2013 Oct 3;11:161. doi: 10.1186/1477-7525-11-161. PMID: 24088389 

Khanna D, Gladue H, Channick R, Chung L, Distler O, Furst DE, Hachulla E, Humbert M, Langleben D, Mathai SC, Saggar R, Visovatti S, Altorok N, Townsend W, FitzGerald J, McLaughlin VV. Recommendations for screening and detection of connective tissue disease-associated pulmonary arterial hypertension. Arthritis Rheum. 2013 Dec;65(12):3194-201. doi: 10.1002/art.38172. PMID: 24022584

Tedford RJ, Mudd JO, Girgis RE, Mathai SC, Zaiman AL, Housten-Harris T, Boyce D, Kelemen BW,  Bacher AC, Shah AA, Hummers LK, Wigley FM, Russell SD, Saggar R, Saggar R, Maughan WL, Hassoun PM, Kass DA. Right ventricular dysfunction in systemic sclerosis-associated pulmonary arterial hypertension. Circ Heart Fail. 2013 Sep 1;6(5):953-63. PMID: 23797369

Mathai SC, Wise RA, Puhan MA, Lam D. Reply from the authors. Am J Respir Crit Care Med. 2013 Mar 15;187(6):659. No abstract available. PMID: 23614142

Yarmus LB, Akulian JA, Gilbert C, Mathai SC, Sathiyamoorthy S, Sahetya S, Harris K, Gillespie C, Haas A, Feller-Kopman D, Sterman D, Lee HJ. Comparison of moderate versus deep sedation for endobronchial ultrasound transbronchial needle aspiration. Ann Am Thorac Soc. 2013 Apr;10(2):121-6. doi: 10.1513/AnnalsATS.201209-074OC. PMID: 23607840

Mathai SC. A look to the past, present, and future of pulmonary hypertension. Int J Clin Pract Suppl. 2013 May;(179):1. doi: 10.1111/ijcp.12173. No abstract available. PMID: 23578067

Mathai SC, Hassoun PM. Drs. Mathai and Hassoun reply. J Rheumatol. 2013 Jan;40(1):91. No abstract available. PMID: 23401876 

Mathai SC. Solvitur ambulando…or maybe not? Chest. 2013 Feb 1;143(2):285-7. doi: 10.1378/chest.12-1819. No abstract available. PMID: 23381304

Shehata ML, Harouni AA, Skrok J, Basha TA, Boyce D, Lechtzin N, Mathai SC, Girgis R, Osman NF, Lima JA, Bluemke DA, Hassoun PM, Vogel-Claussen J. Regional and global biventricular function in pulmonary arterial hypertension: a cardiac MR imaging study. Radiology. 2013 Jan;266(1):114-22. doi: 10.1148/radiol.12111599. Epub 2012 Nov 14. PMID: 23151825

Activities & Honors


  • Frederick L. Brancati Award for Mentorship

Professional Activities

  • Chair, Pulmonary Vascular Disease Network, American College of Chest Physicians
  • Rare Disease Advisory Panel, Patient Centered Outcomes Research Institute
  • Scientific Leadership Council, Pulmonary Hypertension Association
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