- Co-Director, Integrated Physiology Core of Diabetes Research Center
- Associate Professor of Psychiatry and Behavioral Sciences
Sheng Bi, M.D., M.M.
Neural mechanisms of ingestive behavior; Central modulation of fat browning, brown fat thermogenesis and energy expenditure; Neural mechanisms of feeding effects of exercise; Hypothalamic regulation of glucose homeostasis; Obesity; Metabolic syndrome; Insulin resistance and Diabetes ...read more
The overall goal of our research projects is to elucidate the neural mechanisms underlying the controls of food intake and energy expenditure and in the regulation of glucose homeostasis. Currently, we have four main projects: (1) to decipher the hypothalamic-brainstem systems in controlling ingestive behavior, (2) to tease out the neural signaling pathways in modulating fat browning and brown fat thermogenesis, (3) to identify neural circuits and molecules involved in the hypothalamic regulation of hepatic glucose production and insulin sensitivity, and (4) to unravel the neural mechanisms of feeding effects of exercise such as exercise-induced anorexia. We conduct researches using both in vivo animal and in vitro cell culture models with various techniques at genetic, molecular, cellular, neurochemical, pharmacological and behavioral levels. Overall, we aim to explore potential molecules and/or approaches for the prevention and treatment of disordered feeding behaviors, obesity and associated comorbidities.
Currently, we are seeking self-motivated and talented young scientists to join our research team.
Bi S. Stress prompts brown fat into combustion. Cell Metabolism. 5;20(2):205-7, 2014.
Bi S, Li L. Browning of white adipose tissue: role of hypothalamic signaling. Ann N Y Acad Sci. 1302:30-4, 2013.
Bi S. Dorsomedial hypothalamic NPY modulation of adiposity and thermogenesis. Physiol Behav. 121:56-60, 2013.
Zheng F, Kim YJ, Chao PT, Bi S. Overexpression of neuropeptide Y in the dorsomedial hypothalamus causes hyperphagia and obesity in rats. Obesity (Silver Spring). 21(6):1086-92, 2013.
Zhu G, Yan J, Smith WW, Moran TH, Bi S. Roles of dorsomedial hypothalamic cholecystokinin signaling in the controls of meal patterns and glucose homeostasis. Physiol Behav. 105(2):234-41, 2012.
Chao PT, Yang L, Aja S, Moran TH, Bi S. Knockdown of NPY Expression in the Dorsomedial Hypothalamus Promotes Development of Brown Adipocytes and Prevents Diet-Induced Obesity. Cell Metabolism. 13(5):573-83, 2011.
Yang L, Scott KA, Hyun J, Tamashiro KL, Tray N, Moran TH, Bi S. Role of dorsomedial hypothalamic neuropeptide Y in modulating food intake and energy balance. J Neurosci. 29(1):179-90, 2009.
Chen J, Scott KA, Zhao Z, Moran TH, Bi S. Characterization of the feeding inhibition and neural activation produced by dorsomedial hypothalamic cholecystokinin administration. Neuroscience. 152:178–188, 2008.
Bi S, Chen J, Behles RR, Hyun J, Kopin A, Moran TH. Differential body weight and feeding responses to high fat diets in rats and mice lacking cholecystokinin 1 receptors. Am J Physiol Regul Integr Comp Physiol. 293(1):R55-63, 2007.
Kawaguchi M, Scott KA, Moran TH, Bi S. Dorsomedial hypothalamic corticotropin-releasing factor (CRF) mediation of exercise-induced anorexia. Am J Physiol Regul Integr Comp Physiol. 288:R1800-5, 2005.
Bi S, Scott KA, Hyun J, Ladenheim EE, Moran TH. Running wheel activity prevents hyperphagia and obesity in OLETF rats: role of hypothalamic signaling. Endocrinology. 146:1676-85, 2005.
Turning 'Bad' Fat Into 'Good': A Future Treatment For Obesity?, News Releases, Johns Hopkins Medicine 2011
Scientists turn 'bad fat' into 'good fat', Health, BBC News 2011
A fat-burning solution, Nature Reviews Molecular Cell Biology 12, 346 (June 2011)
Master Molecule Rules Fat and More, Hopkins Brain Wise, Winter 2012