Shawn Edward Lupold, Ph.D.

Headshot of Shawn Edward Lupold
  • Catherine Iola and J. Smith Michael Distinguished Professor of Urology
  • Professor of Urology

Research Interests

Prostate Cancer; microRNA and noncoding RNA biology; the tumor immune microenvironment; experimental therapeutics; and high-throughput library development and screening ...read more

Background

Dr. Lupold is the Catherine Iola and J. Smith Michael Distinguished Professor in Urology and Oncology at the Johns Hopkins University School of Medicine. He also has appointments in the Department of Radiation Oncology and Molecular Radiation Sciences and the Cellular and Molecular Medicine (CMM) Graduate Training Program. His research focuses on the molecular biology of prostate cancer, aiming to elucidate disease mechanisms and develop future diagnostic, prognostic, and therapeutic approaches.  Areas of interest include microRNA and noncoding RNA biology, the tumor immune microenvironment, experimental therapeutics, and high-throughput library development and screening.

Dr. Lupold received his B.S. from the University of Maryland, College Park, and trained as a pre-doctoral IRTA fellow at the Laboratory of Human Carcinogenesis at the National Cancer Institute and National Institutes of Health. He received his Ph.D. in Pharmacology and Molecular Sciences from the Johns Hopkins University School of Medicine Biochemistry, Cellular, and Molecular Biology (BCMB) graduate program. He completed a postdoctoral fellowship in prostate cancer gene therapeutics at the Brady Urological Research Institute at Johns Hopkins.

Dr. Lupold has led multiple private, NIH, and DOD funded research projects on the study of prostate cancer molecular biology, detection, and targeting.  He has published extensively on prostate cancer biology and holds several patents for discoveries associated with prostate-specific cell targeting and detection. He has received recognition for his work including the Society of Basic Urologic Research Young Investigator Award and collaborative work that received the Johns Hopkins Institute for Clinical and Translational Research (ICTR) Team Science Award. Dr. Lupold has also served as Associate Editor of the American Journal of Clinical and Experimental Urology and The Prostate, as a member of the American Urological Association Research Council, and as Treasurer, Vice President, and President of the Society of Basic Urologic Research. 

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Titles

  • Catherine Iola and J. Smith Michael Distinguished Professor of Urology
  • Co-Director, Prostate Cancer Program
  • Professor of Urology
  • Assistant Professor of Radiation Oncology and Molecular Radiation Sciences
  • Professor of Oncology

Departments / Divisions

Centers & Institutes

Education

Degrees

  • Ph.D.; Johns Hopkins University School of Medicine (Maryland) (2001)
  • B.S.; University of Maryland (College Park) (Maryland) (1992)

Additional Training

Johns Hopkins Deans Leadership Development Program 2013

Johns Hopkins Executive Leadership Development Program 2024

Research & Publications

Research Summary

The Lupold Lab focuses on the molecular biology of prostate cancer, aiming to elucidate disease mechanisms and develop future diagnostic, prognostic, and therapeutic approaches. Areas of interest include microRNA and noncoding RNA biology, the tumor immune microenvironment, experimental therapeutics, and high-throughput library development and screening.

Selected Publications

View all on PubMed

Aggravated Androgen Receptor Activity in Otherwise Indolent Prostate Cancer. Lupold SE, Isaacs WB, Luo J. Eur Urol. 2023 Nov;84(5):461-462. doi: 10.1016/j.eururo.2023.08.006. Epub 2023 Aug 25

Longitudinal measurement of subcutaneous and intratibial human prostate cancer xenograft growth and response to ionizing radiation by plasma Alu and LINE-1 ctDNA: A comparison to standard methods. Mishra A, Zennami K, Velarde E, Thorek DLJ, Yegnasubramanian S, DeWeese TL, Lupold SE. Prostate. 2021 Aug;81(11):745-753. doi: 10.1002/pros.24171. Epub 2021 May 25

PDCD4 Is an Androgen-Repressed Tumor Suppressor that Regulates Prostate Cancer Growth and Castration Resistance. Zennami K, Choi SM, Liao R, Li Y, Dinalankara W, Marchionni L, Rafiqi FH, Kurozumi A, Hatano K, Lupold SE. Mol Cancer Res. 2019 Feb;17(2):618-627. doi: 10.1158/1541-7786.MCR-18-0837. Epub 2018 Dec 5

Cell-type specific expression of oncogenic and tumor suppressive microRNAs in the human prostate and prostate cancer. Kumar B, Rosenberg AZ, Choi SM, Fox-Talbot K, De Marzo AM, Nonn L, Brennen WN, Marchionni L, Halushka MK, Lupold SE. Sci Rep. 2018 May 8;8(1):7189. doi: 10.1038/s41598-018-25320-z

Differential long-term stability of microRNAs and RNU6B snRNA in 12-20 year old archived formalin-fixed paraffin-embedded specimens. Peskoe SB, Barber JR, Zheng Q, Meeker AK, De Marzo AM, Platz EA, Lupold SE. BMC Cancer. 2017 Jan 6;17(1):32. doi: 10.1186/s12885-016-3008-4

Patents

Nucleic Acid Ligands to the Prostate Specific Membrane Antigen
Patent # US 6,933,114 | 

Peptides for Targeting the Prostate Specific Membrane Antigen
Patent # US 7,749,986 | 

Adenoviral fiber exchange shuttle system
Patent # US 8,088,621 | 

Compositions and methods for generating and screening adenoviral libraries
Patent # US 9,018,138 | 

Compositions and methods for detecting and quantifying circulating tumor cells (CTCs)
Patent # USPA 20140017668 | 

Compositions and methods for retargeting virus constructs
Patent # US 9,458,473 | 

Radiation sensitization agents for prostate cancer
Patent # US 9,029,340 | 

A PSMA-based Gene Reporter-probe System.
Patent # US 11,124,845 | 

Contact for Research Inquiries

600 N Wolfe St.
Park 209
Baltimore, MD 21287 map

Academic Affiliations & Courses

Graduate Program Affiliation

Cellular and Molecular Medicine (CMM)

Courses and Syllabi

  • Topics in Interdisciplinary Medicine (TIME) - Cancer course (ME:800.651)
    Johns Hopkins University School of Medicine
    2017 - 2023

Activities & Honors

Honors

  • Phyllis and Brian L. Harvey Scholar, Patrick C. Walsh Prostate Cancer Research Fund, 2009
  • Society for Basic Urologic Research Young Investigator Award, 2009
  • Department of Defense PCRP New Investigator Award, 2008
  • BioVision.Nxt Fellow, 2007
  • Virginia and Warren Schwerin Scholar, Patrick C. Walsh Prostate Cancer Research Fund, 2006
  • CPDR Distinguished Lecturer, 2005
  • Prostate Cancer Foundation Career Development Award, 2004
  • Pre-doctoral Intramural Research Training Award (IRTA), 1993
  • The Hinman Urologic Education Endowed Fund Scholar, The James Buchanan Brady Urological Institute, 2013 - 2016
  • The Catherine Iola and J. Smith Michael Distinguished Professorship in Urology, The James Buchanan Brady Urological Institute, 2016
  • Team Science Award, Johns Hopkins Institute for Clinical and Translational Research, 2021
  • Member at Large, Society of Basic Urologic Research, 2013 - 2015
  • Treasurer, Society of Basic Urologic Research, 2016 - 2020
  • President Elect, Society of Basic Urologic Research, 2022 - 2023
  • President, Society of Basic Urologic Research, 2023 - 2024

Memberships

  • American Association for Cancer Research, 1999
  • American Society of Gene and Cell Therapy, 2003 - 2013
  • Society for Basic Urologic Research, 2006
  • American Urological Associciation, 2015

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