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Seth Shay Martin, M.D., M.H.S.

Seth Shay Martin, M.D., M.H.S.

Headshot of Seth Shay Martin
  • Director of the Advanced Lipid Disorders Program and Digital Health Lab, Ciccarone Center for the Prevention of Cardiovascular Disease
  • Associate Professor of Medicine


Abdominal Aneurysms, Arterial Occlusive Disease, Atherosclerosis, Atherosclerosis Imaging, Cardiac Disease, Cardiology, Cardiovascular Disease, Cardiovascular Medicine, Cardiovascular Risk Stratification, Chest Pain, Clinical Cardiology, Clinical Lipidology, Coronary Artery Disease, Dyslipidemia, General Cardiology, Heart Attack, Heart Disease, High Blood Pressure (Hypertension), High Cholesterol, Inherited Heart Diseases, Ischemic Heart Disease, Preventive Cardiology, Risk Factor Modification, Stress Testing, Subclinical Atherosclerosis, Valvular Heart Disease more

Research Interests

Cardiovascular Risk Assessment; Dyslipidemia; Mobile Health Technology; Primary and secondary prevention of coronary heart disease; Individuals with a family history of heart disease; Improved strategies for management of cardiovascular risk factors; Preventive Cardiology; Atherosclerosis Imaging; Lipids more

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The Johns Hopkins Hospital

Appointment Phone: 410-502-0469
600 N. Wolfe Street
Carnegie 591
Baltimore, MD 21287 map
Fax: 410-367-2224


Dr. Seth Martin received a Bachelor of Science degree from Washington and Lee University, graduating summa cum laude and Phi Beta Kappa. He went on to earn his medical degree from the University of Pennsylvania and train in internal medicine at Duke University.

While completing a cardiology fellowship at the Johns Hopkins University School of Medicine, Dr. Martin was designated the Marie-Josée & Henry R. Kravis Cardiovascular Fellow and served as a Pollin Cardiovascular Prevention Fellow. During his fellowship, Dr. Martin obtained a Master of Health Science degree at the Johns Hopkins Bloomberg School of Public Health. He was also awarded the Howard S. Silverman Award for originality and creativity in medical research, and the American College of Cardiology recognized him as an Up and Coming Future Star of Cardiology.

Dr. Martin joined the Johns Hopkins cardiology faculty in 2015. He is a core faculty member at the Ciccarone Center for the Prevention of Cardiovascular Disease, where he directs the Advanced Lipid Disorders Program and co-directs the Digital Health Innovations Lab. Dr. Martin serves as co-director of the Johns Hopkins Center for Mobile Technologies to Achieve Equity in Cardiovascular Health (mTECH), which is part of the American Heart Association’s Strategically Focused Research Networks on Health Technology & Innovation. Dr. Martin is also a core faculty member in the Johns Hopkins Center for Health Equity, associate faculty member at the Welch Center for Prevention, Epidemiology and Clinical Research, and an affiliate faculty member at the Malone Center for Engineering in Healthcare.

With research grounded in preventive cardiology, Dr. Martin focuses on multiple complementary areas including digital/mobile health technology, lipidology, cardiovascular risk assessment, health equity, big data and precision medicine. Using a database of more than 1 million patients, Dr. Martin led the development of an improved LDL cholesterol algorithm that was externally validated in databases, cohort studies, and clinical trials, and has been clinically adopted at scale around the world in professional guidelines and practice.

A dedicated clinician and clinical educator, Dr. Martin is a member of the Johns Hopkins bedside medicine faculty. He is an attending physician at The Johns Hopkins Hospital on the general cardiology service, cardiology consult service and the Osler medical service. He is also a firm faculty clinical coach and educator for the Osler medical residency’s Janeway firm. At the Johns Hopkins Outpatient Center, he sees patients in the lipid and preventive cardiology clinics. 

Dr. Martin is invested in the careers of early-stage investigators to build a diverse biomedical research workforce to promote equity in health and healthcare. He has also mentored >70 trainees, including students, residents, fellows, and young faculty, in clinical research and innovation. In 2020, the Johns Hopkins Department of Medicine honored him with the Frederick L. Brancati Excellence in Mentoring Award.

Dr. Martin has published more than 230 articles in leading cardiology and medicine journals, as well as 15 book chapters. He contributed to an update on preventive cardiology published in Braunwald’s Heart Disease: A Textbook of Cardiovascular Medicine. He is an associate editor of the American College of Cardiology’s Dyslipidemia Clinical Community and the Journal of Clinical Lipidology, and he has been a guest editor for the journals Circulation and NPJ Digital Medicine.

Dr. Martin was selected as one of 125 individuals who personify Johns Hopkins Medicine’s mission to improve the health of the community and the world by setting the standard of excellence in medical education, research and clinical care, in celebration of the Johns Hopkins University School of Medicine’s 125th anniversary. more


  • Director of the Advanced Lipid Disorders Program and Digital Health Lab, Ciccarone Center for the Prevention of Cardiovascular Disease
  • Associate Professor of Medicine

Departments / Divisions

Centers & Institutes



  • MD; University of Pennsylvania School of Medicine (2008)


  • Internal Medicine; Duke University School of Medicine (2011)


  • Cardiology; Johns Hopkins University School of Medicine (2015)

Board Certifications

  • American Board of Internal Medicine (Cardiovascular Disease) (2014)

Research & Publications

Clinical Trials

mActive: A Blinded, Randomized mHealth Activity Trial

Selected Publications

View all on PubMed

Martin SS, Blaha MJ, Elshazly MB, Toth PP, Kwiterovich PO, Blumenthal RS, Jones SR. Comparison of a novel method vs the Friedewald equation for estimating low-density lipoprotein cholesterol levels from the standard lipid profile. JAMA. 2013 Nov 20;310(19):2061-8. doi: 10.1001/jama.2013.280532. PubMed PMID: 24240933; PubMed Central PMCID: PMC4226221

Sathiyakumar V, Park J, Golozar A, Lazo M, Quispe R, Guallar E, Blumenthal RS, Jones SR, Martin SS. Fasting Versus Nonfasting and Low-Density Lipoprotein Cholesterol Accuracy. Circulation. 2018 Jan 2;137(1):10-19. doi: 10.1161/CIRCULATIONAHA.117.030677. Epub 2017 Oct 16. PMID: 29038168

Martin SS, Giugliano RP, Murphy SA, Wasserman SM, Stein EA, Ceska R, Lopez-Miranda J, Georgiev B, Lorenzatti AJ, Tikkanen MJ, Sever PS, Keech AC, Pedersen TR, Sabatine MS. Comparison of Low-density Lipoprotein Cholesterol Assessment by Martin/Hopkins Estimation, Friedewald Estimation, and Preparative Ultracentrifugation: Insights From the FOURIER Trial. JAMA Cardiol. 2018 Jun 13. doi: 10.1001/jamacardio.2018.1533. [Epub ahead of print] PMID: 29898218

Martin SS, Feldman DI, Blumenthal RS, Jones SR, Post WS, McKibben RA, Michos ED, Ndumele CE, Ratchford EV, Coresh J, Blaha MJ. mActive: A Randomized Clinical Trial of an Automated mHealth Intervention for Physical Activity Promotion. J Am Heart Assoc. 2015 Nov 9;4(11). pii: e002239. doi: 10.1161/JAHA.115.002239.

Marvel FA, Spaulding EM, Lee MA, Yang WE, Demo R, Ding J, Wang J, Xun H, Shah LM, Weng D, Carter J, Majmudar M, Elgin E, Sheidy J, McLin R, Flowers J, Vilarino V, Lumelsky DN, Bhardwaj V, Padula WV, Shan R, Huynh PP, Wongvibulsin S, Leung C, Allen JK, Martin SS. Digital Health Intervention in Acute Myocardial Infarction. Circ Cardiovasc Qual Outcomes. 2021 Jul;14(7):e007741. doi: 10.1161/CIRCOUTCOMES.121.007741. Epub 2021 Jul 15.

Activities & Honors


  • Robert M. Califf & Barton F. Haynes House Staff Research Award, Duke University Medical Center
  • Stanley L. Blumenthal, MD Cardiology Research Award, Johns Hopkins University School of Medicine
  • Up and Coming Future Stars of Cardiology, American College of Cardiology
  • Howard S. Silverman Research Award for Originality & Creativity in Medical Research, Johns Hopkins University School of Medicine
  • Steven N. Blair Award for Excellence in Physical Activity Research, AHA Council on Lifestyle and Cardiometabolic Health
  • Anna Huffstutler Stiles Award in recognition of outstanding academic achievement and innovative thesis research, Johns Hopkins Bloomberg School of Public Health
  • PJ Schafer Cardiovascular Research Award, PJ Schafer Memorial Fund
  • Multi-Ethnic Study of Atherosclerosis Early Career Investigator Award
  • Stanford Medicine X Global Research Challenge Finalist
  • Young Investigator Award, National Lipid Association
  • Cardiology Today Next Gen Innovators Award
  • Selected as one of 125 individuals who personify Johns Hopkins Medicine’s mission to improve the health of the community and the world by setting the standard of excellence in medical education, research and clinical care, in celebration of the 125th Johns Hopkins Medicine anniversary
  • Frederick L. Brancati Excellence in Mentoring Award from the Johns Hopkins Department of Medicine


  • American Heart Association


  • American College of Cardiology


  • Johns Hopkins Institute for Data-Intensive Engineering and Science
  • The Thistle Society, Perelman School of Medicine at the University of Pennsylvania
  • The FH Foundation
  • The American Society for Preventive Cardiology

    Fellow and Board Member

  • Lipoprotein(a) Foundation

    Board Member

  • National Lipid Association

Professional Activities

  • Member, State Advisory Council on Heart Disease and Stroke Prevention, Maryland Department of Health and Mental Hygiene, 2017
  • Member, Lipoprotein(a) Foundation Advisory Board, 2016
  • Team Coach, American Heart Association Greater Baltimore Heart Walk, 2014
  • Chair, American Heart Association Advocacy Coordinating Committee, 2017
  • Member, American Heart Association EPI Early Career Committee
  • Member, American Heart Association Science Clinical Education Lifelong Learning Committee
  • Vice Chair, American Heart Association Statistics Committee
  • Board Member, The American Society of Preventive Cardiology
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