Dr. Bagnasco's research interests are in the field of renal physiology / pathophysiology, and pathology.
She has studied the mechanisms of adaptation of renal cells to the environment of the kidney medulla, characterized by high concentration of salt and urea.
She and her team have defined the genomic organization of the gene that encodes the major renal urea transporters, which are essential for the process of urine concentration in the mammalian kidney. She has elucidated some of the major pathways regulating expression and function of these transporters in the kidney and at extrarenal sites.
She is involved in collaborative multicenter studies on the characteristics of glomerular diseases as part of the NEPTUNE and CureGN consortia.
She is the central pathologist for the HOPE in action clinical trial of HIV to HIV deceased donor kidney transplantation.
She is leading two working groups studying HIV/HIV kidney transplantation and recurrent glomerulonephritis within the Banff organization.
Clinical Trial Keywords
HOPE in action clinical trial of HIV to HIV deceased donor kidney transplantation
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Nakayama Y, Peng T, Sands JM, Bagnasco SM. The TonE/TonEBP pathway mediates tonicity-responsive regulation of UT-A urea transporter expression. Journal of Biological Chemistry. 2000;275:38275-38280.
Bagnasco SM, Zachary AA, Racusen LC, Arend LJ, Carter-Monroe N, Alachkar N, Nazarian SM, Lonze BE, Montgomery RA, Kraus ES. Time Course of Pathologic Changes in Kidney Allografts of Positive Crossmatch HLA-Incompatible Transplant Recipients. Transplantation. 2014; 97:440-445.
Mariani LH, Martini S, Barisoni L, Canetta PA, Troost JP, Hodgin JB, Palmer M, Rosenberg AZ, Lemley KV, Chien HP, Zee J, Smith A, Appel GB, Trachtman H, Hewitt SM, Kretzler M, Bagnasco SM: Interstitial fibrosis scored on whole slide digital imaging of kidney biopsies is a predictor of outcome in proteinuric glomerulopathies. Nephrol Dial Transplant. 2018, 33:310-318
Haas M, Loupy A, Lefaucheur C, Roufosse C, Glotz D, Seron D, Nankivell BJ, Halloran PF, Colvin RB, Akalin E, Alachkar N, Bagnasco S, Bouatou Y, Becker JU, Cornell LD, van Huyen JPD, Gibson IW, Kraus ES, Mannon RB, Naesens M, Nickeleit V, Nickerson P, Segev DL, Singh HK, Stegall M, Randhawa P, Racusen L, Solez K, Mengel M. The Banff 2017 kidney meeting report: revised diagnostic criteria for chronic active T cell-mediated rejection, antibody-mediated rejection, and prospects for integrative endpoints for next-generation clinical trials. Am J Transplant. 2018;18:293-307
Bagnasco SM. Beyond the microscope, interpreting renal biopsy findings in the era of precision medicine. Am J Physiol Renal Physiol. 315(6):F1652-F1655, 2018 PMID:30280602