Sara Elizabeth Cosgrove, M.D.

Headshot of Sara Elizabeth Cosgrove
  • Director, Johns Hopkins Hospital Department of Antimicrobial Stewardship
  • Professor of Medicine


Infectious Disease

Research Interests

Development of tools and programs to promote rational use of antimicrobials; Epidemiology and outcomes of antimicrobial resistance; Epidemiology and management of S. aureus bacteremia; Prevention of hospital-acquired infections more

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The Johns Hopkins Hospital (Main Entrance)

Appointment Phone: 410-955-1725
1800 Orleans St.
Sheikh Zayed Tower
Baltimore, MD 21287
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Dr. Cosgrove is a Professor of Medicine in the Division of Infectious Disease (ID) at Johns Hopkins University School of Medicine and has a joint appointment in the Department of Epidemiology at the Johns Hopkins Bloomberg School of Public Health. She is the Director of Research for the ID Fellowship Program and PI of the T32 training grant that supports ID fellow training. She serves as the Director of the Department of Antimicrobial Stewardship and an Associate Hospital Epidemiologist at The Johns Hopkins Hospital. Dr. Cosgrove’s research interests include the epidemiology and outcomes of antimicrobial resistance, the development of tools and programs to promote the rational use of antimicrobials, the prevention of hospital-acquired infections, and the epidemiology and management of S. aureus bacteremia. Early in her career, she recognized the critical need to study antimicrobial stewardship strategies and has led a series of outcomes studies over the past 20 years that have defined the practice of antimicrobial stewardship in the United States. Her recent research focuses on strategies for implementation of antimicrobial stewardship activities across all healthcare settings via a large, multi-center project including hospitals, long-term care facilities and ambulatory practices funded by the Agency for Healthcare Research and Quality, and approaches to improve how antibiotics are given via a randomized trial to compare intravenous and oral therapy for Gram negative bacteremia funded by PCORI. She is the PI of the Johns Hopkins Prevention Epicenter, a Centers for Disease Control and Prevention-funded program that integrates antimicrobial stewardship, healthcare epidemiology, human factors engineering, data science, and implementation science to address knowledge gaps and develop strategies to optimize patient safety by preventing transmission of pathogens and improving antibiotic use in diverse healthcare settings and patient populations. She is a past voting member of the Presidential Advisory Council on Combating Antibiotic-Resistant Bacteria. She is a Past President of the Society for Healthcare Epidemiology’s Board of Directors. Dr. Cosgrove received her undergraduate degree from Columbia College, her medical degree from Baylor College of Medicine, and her master of science degree in epidemiology from Harvard School of Public Health. She completed her postgraduate training in internal medicine at The Johns Hopkins Hospital and underwent subsequent training in ID at Beth Israel Deaconess Medical Center. more


  • Director, Johns Hopkins Hospital Department of Antimicrobial Stewardship
  • Associate Hospital Epidemiologist, Johns Hopkins Hospital
  • Director of Research, ID Fellowship Program
  • Professor of Medicine

Departments / Divisions

Centers & Institutes



  • MD; Medicine; Baylor College of Medicine (1995)


  • Medicine; Johns Hopkins University School of Medicine (1998)


  • Infectious Diseases; Beth Israel Deaconess Medical Center (2001)

Board Certifications

  • American Board of Internal Medicine (Infectious Disease) (2000)

Research & Publications

Selected Publications

View all on PubMed

Tamma PD, Miller MA, Dullabh, Ahn R, Speck K, Gao Y, Scherpf, Cosgrove SE. Association of a safety program for improving antibiotic use with antibiotic use and hospital-onset Clostridioides difficile infection rates among US hospitals. JAMA Network Open. 2021:4(2):e210235. doi:10.1001/jamanetworkopen.2021.0235

Fabre V, Klein E, Salinas AB, Jones G, Carroll KC, Milstone AM, Amoah J, Hsu YJ, Gadala A, Desai S, Goyal A, Furfaro D, Zimmerman J, Lin S, Cosgrove SE. A diagnostic stewardship intervention to improve blood culture use among adult nonneutropenic inpatients: the DISTRIBUTE study. J Clin Microbiol. 2020; 22;58(10):e01053-20

Thom KA, Tamma PD, Harris AD, Dzintars K, Morgan DJ, Li S, Pineles L, Srinivasan A, Avdic E, Cosgrove SE. Impact of a prescriber-driven antibiotic time-out on antibiotic use in hospitalized patients. Clin Infect Dis. 2019 Apr 24;68(9):1581-1584

Tamma PD, Avdic E, Li DX, Dzintars K, Cosgrove SE. Adverse events associated with antibiotic use in hospitalized patients. JAMA Internal Medicine. 2017 Sep1;177(9):1308-15

Tamma PD, Avdic E, Keenan JF, Zhao Y, Anand G, Cooper J, Dezube R, Hsu S, Cosgrove SE. What is the more effective antibiotic stewardship intervention, pre-prescription authorization or post-prescription review with feedback? Clin Infect Dis. 2017; Mar 1;64(5):537-543

Contact for Research Inquiries

Academic Office
600 N. Wolfe St
Halsted 827
Baltimore, MD 21287 map
Phone: 443-287-4570

Activities & Honors


  • Susan MacDonald Annual Sponsorship Award, JHU Department of Medicine, 2022
  • Expertscape Top Worldwide Expert in Antimicrobial Stewardship, 2021
  • Member, American Society of Clinical Investigation, 2020
  • SHEA Antibiotic Stewardship Scholarship Award, 2017
  • IDSA Oswald Avery Award, 2014


  • Society for Healthcare Epidemiology of America
  • Infectious Diseases Society of America
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