Ross C Donehower, M.D.

Headshot of Ross C Donehower
  • Director, Medical Oncology/Hematology Fellowship Training Program
  • Professor of Oncology


Anal Cancer, Bile Duct Cancer, Carcinoid Syndrome, Carcinoid Tumors, Cholangiocarcinoma, Clinical Trials, Colon Cancer, Colorectal Cancer, Gastric Cancer, Gastroesophageal Junction Cancer, Gastrointestinal Cancers, Gastrointestinal Tumors, Hepatocellular Carcinoma, Liver Cancer, Medical Oncology, Neuroendocrine Tumors, Pancreatic Cancer, Rectal Cancer, Small Bowel Cancer, Small Intestine Cancer, Stomach Cancer more

Research Interests

Gastrointestinal Cancers; New Anticancer Drug Development; Pharmacology more

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Main Phone

Outside of Maryland & Washington D.C.

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Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

Appointment Phone: 410-955-8964
401 N. Broadway
Baltimore, MD 21231
Johns Hopkins Sidney Kimmel Comprehensive Cancer Center - Google Maps

Johns Hopkins Medicine - Green Spring Station

Appointment Phone: 410-583-2970
10753 Falls Road
Pavilion II
Lutherville-Timonium, MD 21093
Johns Hopkins Medicine - Green Spring Station - Google Maps


Dr. Ross C. Donehower is an oncologist in the Baltimore area, caring for patients with gastrointestinal cancers. He was part of the team that developed premedications that allowed paclitaxel — a chemotherapy medication now used to treat several types of cancers — to be safely given to patients. The Virginia and D.K. Ludwig Professor in Clinical Investigation of Cancer, he serves as the director of the Hematology & Medical Oncology Fellowship Program and director of the Division of Medical Oncology at the Johns Hopkins School of Medicine.

Dr. Donehower received his undergraduate degree from Hamline University and earned his M.D. from the University of Minnesota. He completed his residency at The Johns Hopkins Hospital. Dr. Donehower joined the Johns Hopkins faculty in 1980.

Prior to joining Johns Hopkins, Dr. Donehower was a surgeon with the U.S. Public Health Service and a clinical associate of the medicine branch and clinical pharmacology branch at the National Cancer Institute.

His research interests include gastrointestinal cancers, new anticancer drug development and pharmacology.

Dr. Donehower serves on the editorial boards of numerous scholarly journals, including the International Journal of Oncology. He has been recognized by the American Society of Clinical Oncology with a 2017 Excellence in Teaching Award. He is a member of several professional organizations, including the American College of Physicians, the American Society of Clinical Oncology and the American Association for Cancer Research. more


  • Director, Medical Oncology/Hematology Fellowship Training Program
  • Director, Division of Medical Oncology
  • Virginia and D.K. Ludwig Professor in Clinical Investigation of Cancer
  • Professor of Oncology
  • Professor of Medicine

Departments / Divisions

Centers & Institutes



  • MD; University of Minnesota Medical School (1974)


  • Internal Medicine; Johns Hopkins University School of Medicine (1976)


  • Medical Oncology; National Institutes of Health (1980)

Board Certifications

  • American Board of Internal Medicine (Internal Medicine) (1977)
  • American Board of Internal Medicine (Medical Oncology) (1979)

Research & Publications

Selected Publications

Naik RP, Marrone K, Merrill S, Donehower R, Brodsky R. “Single-board hematology fellowship track: A 10-year institutional experience.” Blood. 2018;131(4):462-464

Reiss KA, Rangachari D, Cosgrove D, Wilky B, Donehower R. “Growing pains: A simulation-based curriculum for improving the transition to hematology/oncology fellowship.” J Cancer Educ. 2017;32(3):496-502

Le DT, Durham JN, Smith KN, Wang H, Bartlett BR, Aulakh LK, Lu S, Kemberling H, Wilt C, Luber BS, Wong F, Azad NS, Rucki AA, Laheru D, Donehower R, Zaheer A, Fisher GA, Crocenzi TS, Lee JJ, Greten TF, Duggy AG, Ciombor KK, Eyring AD, Lam BH, Joe A, Kang SP, Holdhofff M, Danilova L, Cope L, Meyer C, Zhou S, Goldberg RM, Armstrong DK, Bever KM, Fader AN, Taub J, Housseau F, Spetzler D, Xiao N, Pardoll DM, Papadopoulos N, Kinzler KW Exhleman JR, Vogelstein B, Anders RA, Diaz LA Jr. “Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade.” Science. 2017;357(6349):409-413

Shrestha B, Sun Y, Faisal F, Kim V, Soares K, Blair A, Herman JM, Narang A, Dholakia AS, Rosati L, Hacker-Prietz A, Chen L, Laheru, DA, DeJesus-Acosta A, Le DT, Donehower R, Azad N, Diaz LA, Murphy A, Lee V, Fishman EK, Hruban RH, Liang T, Cameron JL, Makary M, Weiss MJ, Ahuja N, He J, Wolfgang CL, Huang CY, Zheng L. “Long-term survival benefit of upfront chemotherapy in patients with newly diagnosed borderline resectable pancreatic cancer.” Cancer Med. 2017;6(7):1552-1562

Yarchoan M, Myzak MC, Johnson BA 3rd, De Jesus-Acosta A, Le DT, Jaffee EM, Azad NS, Donehower RC, Zheng L, Oberstein PE, Fine RL, Laheru DA, Goggins M. “Olaparib in combination with irinotecan, cisplatin, and mitomycin C in patients with advanced pancreatic cancer.” Oncotarget. 2017 Jul 4;8(27):44073-44081

Activities & Honors


  • Excellence in Teaching Award, American Society of Clinical Oncology, 2017
  • Director’s Teaching Award, Johns Hopkins Cancer Center, 2016
  • Member, Miller-Coulson Academy of Clinical Excellence, Johns Hopkins School of Medicine, 2015


  • American College of Physicians
  • American Society of Clinical Oncology
  • American Association for Cancer Research
  • European Society of Medical Oncology

Professional Activities

  • Faculty Senate, Johns Hopkins School of Medicine, 2019
  • Editorial Board, International Journal of Oncology, 2002
  • Editorial Board, Investigational New Drugs, 1998
  • Associate Editor, The Oncologist, 1996
  • Associate Editor, Journal of the National Cancer Institute, 1994
  • Editorial Board, Clinical Cancer Research, 1994
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