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R. Scott Stephens, M.D.

Robert Scott Stephens, M.D.

Headshot of R. Scott Stephens
  • Director, Oncology and Bone Marrow Transplant Critical Care
  • Associate Professor of Medicine


Acute Respiratory Distress Syndrome (ARDS), Cardiac Disease, Pulmonary and Critical Care Medicine, Septic Shock more

Research Interests

Acute Respiratory Distress Syndrome; Pulmonary Endothelial Barrier Function; Extracorporeal Membrane Oxygenation; Pulmonary Endothelial Antioxidant Regulation; Acute Respiratory Failure; Critical Care Education more

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The Johns Hopkins Hospital

Appointment Phone: 410-955-3467
1830 E. Monument Street
1830 Building 5th Floor Pulmonary
Baltimore, MD 21287 map
Phone: 410-550-0545

Johns Hopkins Bayview Medical Center

5501 Hopkins Bayview Circle
Asthma and Allergy Center
Baltimore, MD 21224 map
Phone: 410-550-0545 | Fax: 410-550-2612


Dr. R. Scott Stephens is an associate professor of medicine and oncology at the Johns Hopkins University School of Medicine.  He serves as the Director of Oncology and Bone Marrow Transplant Critical Care at Johns Hopkins Hospital and the Sidney Kimmel Comprehensive Cancer Center. His expertise is in critical care medicine, with a focus on severe acute respiratory distress syndrome (ARDS), acute respiratory failure after hematopoietic stem cell transplant, refractory circulatory shock, and extracorporeal membrane oxygenation (ECMO) for respiratory and circulatory failure. 

Dr. Stephens also has extensive experience in the management of septic shock, neutropenic sepsis, life-threatening oncologic complications, and pulmonary embolism, as well as other common critical care conditions. He also has expertise in cardiac surgical critical care, including the critical care of heart transplant, lung transplant and ventricular assist device patients. 

Dr. Stephens formerly led the Advanced Critical Care Clerkship for fourth-year medical students, and was recognized by the Johns Hopkins Institute for Excellence in Education with an Outstanding Achievement in Education Award (Educational Program) in 2013. He is a member of the American Thoracic Society, and has been selected as an American Thoracic Society Fellow (ATSF).  He is also active in the Society of Critical Care Medicine and the American Physiologic Society. more


  • Director, Oncology and Bone Marrow Transplant Critical Care
  • Associate Professor of Medicine
  • Associate Professor of Oncology

Departments / Divisions

Centers & Institutes



  • MD; University of Pennsylvania School of Medicine (2003)


  • Medicine; Johns Hopkins University School of Medicine (2006)


  • Pulmonary Medicine; Johns Hopkins University School of Medicine (2010)

Board Certifications

  • American Board of Internal Medicine (Critical Care Medicine) (2011)
  • American Board of Internal Medicine (Pulmonary Disease) (2010)

Research & Publications

Research Summary

Dr. Stephens was trained as a basic scientist studying acute lung injury and the role of protein kinase G and c-Abl kinase-mediated signaling in lung endothelial antioxidant regulation.

He has recently shifted his focus to clinical and translational research in acute respiratory failure, and has two primary areas of interest. The first lies in the management of severe ARDS, with particular focus on the role of advanced modalities such as ECMO. His second research focus is in acute respiratory failure after bone marrow transplant, particularly non-myeloablative haploidentical bone marrow transplantation.

He is an active participant in the Society of Critical Care Medicine Discovery Research Network (formerly the United States Critical Illness and Injury Trials Group), and was a member of the steering committee of the Discovery-Program in Emergency Preparedness (PREP). In addition, he is a member of the North American ECMO Research Network and is on the executive committee of the Oncology Critical Care Research Network (ONCCC-R-NET).

Selected Publications

View all on PubMed

Sahetya SK, Brower RG, *Stephens RS.   Survival from Severe ARDS Managed Without Extracorporeal Membrane Oxygenation.  American Journal of Critical Care 2018 May. 27(3): 220-227. PMID: 29716909

Schmidt M, Pham T, Arcadipaine A, Agerstrand C, Ohshimo S, Pelligrino V, Vuylsteke A, Guervilly C, McGuinness S, Pierard S, Breeding J, Stewart C, Ching SSW, Camuso JM, Stephens RS, King B, Herr D, Schultz MJ, Neuville M, Zogheib E, Mira J-P, Roze H, Pierrot M, Tobin A, Hodgson C, Chevret S, Brodie D, Combes A.   Mechanical Ventilation Management During ECMO for ARDS.   American Journal of Respiratory and Critical Care Medicine.  2019.  Oct 15.  200(8):1002-1012.  PMID: 31144997

Gutierrez C, Brown AR, Herr MM, Kadri S, Hill B, Rajendram P, Duggal A, Turtle C, Patel K, Lin Y, May HP, Gallo de Moraes A, Maus M, Frigault M, Brudno J, Athale J, Shah N, Kochenderfer JN, Dharshan A, Beitinjaneh A, Arias S, McEvoy C, Mead E, Stephens RS, Nates J, Neelapu S, Pastores S. The Chimeric Antigen Receptor-Intensive Care Unit (CAR-ICU) Initiative: Surveying Intensive Care Unit Practices in the Management of CAR T-Cell Associated Toxicities.   Journal of Critical Care.  2020 Aug; 58:58-64.  PMID: 32361219

Fornwalt RA, Brigham EP, *Stephens RS.  Critical Care of the Hematopoietic Stem Cell Transplant Patient.  Critical Care Clinics.  2021 Jan. 37(1):29-46.   PMID:33190774

Academic Affiliations & Courses

Courses and Syllabi

  • “Advanced Critical Care Clerkship,” Genes to Society: A Curriculum for the Johns Hopkins University School of Medicine

Activities & Honors


  • Outstanding Achievement in Education Award (Educational Program), Johns Hopkins Institute for Excellence in Education, 2013


  • American Physiologic Society
  • American Thoracic Society
  • Society of Critical Care Medicine

Professional Activities

  • Director, Advanced Critical Care Clerkship, Johns Hopkins
  • Co-Director, Fellowship Program in Pulmonary and Critical Care Medicine, Johns Hopkins

Videos & Media

Lectures and Presentations

  • “Pulmonary and Critical Care Medicine”
    Grand Rounds Program, Johns Hopkins Community Grand Rounds Program
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