Dr. Mittal conducts research in computational modeling of physiological fluid dynamics. He was trained as a fluid dynamicist, and has extensive background in computational fluid dynamics, turbulence, fluid-structure interaction, high-performance computing and biomechanics. For the past fifteen years, he has been developing computational methods to model a variety of physiological flows with particular focus on cardiovascular and cardiac hemodynamics, and phonatory aerodynamics. A hallmark of his research is the development of multiphysics models that couple a variety of physical domains such as fluid flow, solid mechanics, acoustics and biochemistry, in order to provide unique modeling capabilities and insights into the biophysics of organ function in health and disease. Current research focuses on CT based diagnostics for coronary artery disease, biophysics of cardiac auscultation and mechanisms for thrombogenesis, prosthetic heart valves and cerebral aneurysms.
Lab Website: Flow Physics and Computation Lab
Technology Expertise Keywords
Fluid dynamics, hemodynamics, cardiac biomechanics, cardiovascular biomechanics, aneurysms, cardiac prostheses, phonation, speech, biomechanical modeling, speech, acoustics, organ biomechanics, thrombosis.
Seo, J.H., Bakhshaee, H., Garreau, G., Zhu, C., Andreou, A., Thompson, W.R. and Mittal, R., 2017. A method for the computational modeling of the physics of heart murmurs. Journal of Computational Physics, 336, pp.546-568.
Harfi, Thura T., Jung-hee Seo, Hayder S. Yasir, Nathaniel Welsh, Susan A. Mayer, Theodore P. Abraham, Richard T. George, and Rajat Mittal. The E-wave propagation index (EPI): A novel echocardiographic parameter for prediction of left ventricular thrombus. Derivation from computational fluid dynamic modeling and validation on human subjects. International journal of cardiology 227 (2017): 662-667.
Seo, J.H., Abd, T., George, R.T. and Mittal, R., 2016. A coupled chemo-fluidic computational model for thrombogenesis in infarcted left ventricles. American Journal of Physiology-Heart and Circulatory Physiology, 310(11), pp.H1567-H1582.
Xue, Q., Zheng, X., Mittal, R. and Bielamowicz, S., 2014. Subject-specific computational modeling of human phonation. The Journal of the Acoustical Society of America, 135(3), pp.1445-1456.
Mittal, R., Erath, B.D. and Plesniak, M.W., 2013. Fluid dynamics of human phonation and speech. Annual Review of Fluid Mechanics, 45, pp.437-467.