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Rajarsi Mandal, M.D.

Rajarsi Mandal, M.D.

Headshot of Rajarsi Mandal
4.7out of 5
104 Ratings
  • Assistant Professor of Otolaryngology - Head and Neck Surgery


Basal Cell Cancer of the Head and Neck, Benign Tumors of the Head and Neck, Head and Neck Cancers, Head and Neck Surgery, Head and Neck Tumors, HPV- Related Head and Neck Cancer, Hypopharyngeal Cancer, Laryngeal Cancer, Melanoma of the Head and Neck, Nasal Cancer, Oral Cancers, Oropharyngeal Cancer, Salivary Gland Cancer, Salivary Gland Tumors, Sarcoma of the Head and Neck, Sinus Cancer, Skin Cancer of the Head and Neck, Thyroid Masses, Thyroid Surgery, Tonsil Cancer, Transoral robotic surgery (TORS) more

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Johns Hopkins Outpatient Center

Appointment Phone: 443-997-6467
601 N. Caroline St.
6th Floor
Baltimore, MD 21287 map

Johns Hopkins Health Care and Surgery Center

Appointment Phone: 301-896-3332
6420 Rockledge Drive
Suite 4920
Bethesda, MD 20817 map
Fax: 301-530-2650


Dr. Mandal is a head and neck cancer surgeon with expertise in the surgical treatment of benign and malignant tumors of the head and neck, including the upper aerodigestive tract, salivary glands, thyroid and parathyroid glands, and skin. 

He also serves as Director of the Head and Neck Cancer Immunotherapy Research Program at the Johns Hopkins University/Bloomberg-Kimmel Institute for Cancer Immunotherapy. He has specific interest in the treatment and research of advanced head and neck cancers with immune-based therapies. His research efforts involve understanding the genetic and immunologic basis for response to immunotherapy to better personalize immunotherapy cancer care for patients with head and neck cancer. more


  • Assistant Professor of Otolaryngology - Head and Neck Surgery

Departments / Divisions



  • MD; The Ohio State University Wexner Medical Center (2010)


  • Otolaryngology; University of Pittsburgh Medical Center (2015)


  • Memorial Sloan-Kettering Cancer Center (2018)

Board Certifications

  • American Board of Otolaryngology - Head and Neck Surgery (Otolaryngology) (2016)

Research & Publications

Selected Publications

Mandal R, Samstein RM, Lee KW, Havel JJ, Wang H, Krishna C, et al. Genetic diversity of tumors with mismatch repair deficiency influences anti-PD-1 immunotherapy response. Science. 2019;364(6439):485-91

Mandal R, Senbabaoglu Y, Desrichard A, Havel J, Dalin M, Riaz N, Lee K, Ganly I, Hakimi A, Chan T, Morris L. The Head and Neck Cancer Immune Landscape and its Immunotherapeutic Implications. JCI Insight. 2016

Mandal R, Chan TA, Personalized Oncology Meets Immunology: The Path toward Prescision Immunotherapy. Cancer Discovery. 2016

Mandal R, Duvvuri U, Ferris RL, Kaffenberger TM, Choby GW, Kim S. Analysis of post-transoral robotic assisted surgery hemorrhage: frequency, outcomes and prevention. Head Neck. 2015

Riaz N, Havel JJ, Makarov V, Desrichard A, Urba WJ, Sims JS, Hode FS, Martin-Algarra S, Mandal R, et al. Tumor and Microenvironment Evolution during Immunotherapy with Nivolumab. Cell. 2017;171(4):934-49 e15.

Activities & Honors


  • Young Investigator Award, American Society of Clinical Oncology, 2017 - 2018
  • New York Head and Neck Society Proffered Paper Secession Award, New Your Head and Neck Society, 2016


  • American Academy of Otolaryngology-Head and Neck Surgery
  • American Society of Clinical Oncology
  • American Head and Neck Society

Videos & Media

Lectures and Presentations

  • The Genomic and Immunologic Determinants of Response to Cancer Immunotherapy
    Presentation, World Congress, Cambridge Healthtech Institute's Fourteenth Annual Biomarkers and Immuno-Oncology World Congress, Boston, MA (06/11/2018)
    Cambridge Healthtech Institute
  • Shaping of Immunotherapy Response by the Cancer Genome
    presentation, Conference, Twenty-fourth Molecular Medicine Tri-conference, San Francisco, California (02/22/2017)
    Memorial Sloan-Kettering Cancer Center
  • Cancer Neoantigens and Their Role as Predictive Biomarkers for Cancer Immunotherapy
    lecture, Conference, Second Annual Diagnostics to Guide Cancer Immunotherapy Conference, Washington, DC (08/24/2016)
    Cambridge Healthtech Institute
  • The Genomic and Immunologic Determinants of Response to Head and Neck Cancer Immunotherapy
    presentation, conference, Third Annual Biomarkers for Cancer Immunology and Combinations, Washington, DC (08/15/2017)
    Cambridge Healthtech Institute

Recent News Articles and Media Coverage

Tumor Mutations May Predict Response to Immunotherapy Press Release Johns Hopkins Kimmel Cancer Center (5-7-2019) 

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

  • 4.7 Provider Explained Things Clearly
  • 4.6 Provider Listened Carefully
  • 4.6 Provider Knew Medical History
  • 4.7 Provider Showed Respect
  • 4.7 Provider Spent Enough Time
  • 4.6 Overall Rating by Patient


4.7 out of 5 (104 Ratings, 31 Comments)
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