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Phuoc T. Tran, M.D., Ph.D.

Phuoc T. Tran, M.D., Ph.D.

Headshot of Phuoc T. Tran
  • Co-Leader, Cancer Invasion and Metastasis Program (CIM)
  • Professor of Oncology


Adrenal Cancer, Bladder Cancer, Image-Guided Radiation Therapy, Intensity-Modulated Radiation Therapy (IMRT), Metastatic Bone Disease, Metastatic Disease, Oligometastatic Disease, Penile Cancer, Prostate Cancer, Radiation Oncology, Stereotactic Body Radiation Therapy, Testicular Cancer, Urethral Cancer more

Research Interests

Radiosensitizers; Genetically engineered mouse models of disease; Epithelial Plasticity (Epithelial-Mesenchymal Transition and Mesenchymal-Epithelial Transition) more


Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

Appointment Phone: 410-502-8000
401 N. Broadway
Baltimore, MD 21231 map
Phone: 410-614-6477 | Fax: 410-502-2821

The Johns Hopkins Hospital (Main Entrance)

Appointment Phone: 410-502-8000
1800 Orleans St.
Sheikh Zayed Tower
Baltimore, MD 21287 map

Johns Hopkins Medicine - Green Spring Station

10753 Falls Road
Pavilion II Suite 145
Lutherville-Timonium, MD 21093 map
Phone: 410-847-3800 | Fax: 410-847-3805


Dr. Phuoc T. Tran is a professor of radiation oncology and molecular radiation sciences, oncology and urology at the Johns Hopkins School of Medicine.

Dr. Tran treats patients with cancers of the genitourinary system and uses stereotactic radiation techniques (such as SRS and SBRT/SABR) for the treatment of patients with oligometastatic disease. His research focuses on the improvement of clinical radiotherapy for the treatment of primarily prostate cancer, but also adrenal, bladder, urethral, testicular and penile cancer as well as patients with oligometastatic disease.

Dr. Tran completed his medical and graduate training at the Oregon Health & Sciences University in Portland. He conducted a residency in radiation oncology at the Stanford University School of Medicine in 2008 where he was an instructor of radiation oncology before then joining the staff of Johns Hopkins.

Dr. Tran has published more than 150 scholarly works in peer-reviewed journals, has received numerous awards for his research, and is a primary investigator on a number of clinical trials.  He is a member and holds leadership positions in the Radiological Society of North America (RSNA), NRG Oncology and the American Society for Radiology Oncology (ASTRO), and is board certified in radiation oncology by the American Board of Radiology.  He is also a senior editor/editorial board member of Cancer Research and the Journal of Clinical Oncology.

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  • Co-Leader, Cancer Invasion and Metastasis Program (CIM)
  • Professor of Oncology

Departments / Divisions

Centers & Institutes



  • M.D.; Oregon Health & Sciences University School of Dentistry (Oregon) (2003)
  • Ph.D.; Oregon Health & Sciences University School of Dentistry (Oregon) (2001)
  • B.S.; University of California (San Diego) (California) (1996)

Research & Publications

Research Summary

Dr. Tran’s research focuses on the improvement of clinical radiotherapy for the treatment of primarily prostate, as well as adrenal, bladder, penile, testicular and urethral cancer. To learn how tumors arise, how they spread and why some cancers are resistant to treatment, he studies tumor cell epithelial plasticity - transitions of epithelial and mesenchymal cellular states.


Dr. Tran and his laboratory focus their studies on tumor cell epithelial plasticity - the transitions between epithelial and mesenchymal cellular states and the implications of these transitions for tumorigenesis, cancer treatment resistance and radiation-induced fibrosis. Their research utilizes a variety of inducible transgenic mouse models, non-invasive rodent imaging as well as more tradiational molecular, biochemical and cell biologic approaches.  One of these transitions, known as epithelial-mesenchymal transition (EMT), is a conserved developmental program that when inappropriately activated in post-natal life has been associated with organ fibrosis, tumorigenesis and metastasis.

A major focus of the laboratory is the use of inducible mouse models to simulate molecularly targeted therapies for malignancies and radiation induced late effects.

Another focus of the laboratory is the study of novel targeted agents as tumor selective radiosensitizers to increase the therapeutic ratio of clinical radiotherapy.

The Tran lab is committed to translating discoveries from the laboratory bench into novel cancer prevention, diagnostic and treatment approaches that can be tested in the clinic.

Lab Website: The Tran Lab

Technology Expertise Keywords

epithelial plasticity; epithelial-mesenchymal transition (EMT); genetically engineered mouse models (GEMMs)

Clinical Trial Keywords

Prostate cancer; Radiation therapy, Oligometastasis; SBRT/SABR

Clinical Trials

RAdium-223 and SABR Versus SABR for Oligometastatic Prostate Cancers (RAVENS)

Selected Publications

View all on PubMed

Phuoc T. Tran*, Pavan K. Bendapudi*, H. Jill Lin*, Peter Choi, Shan Koh, Joy Chen, George Horng, Nicholas P. Hughes, Lawrence H. Schwartz, Vincent A. Miller, Toshiyuki Kawashima, Toshio Kitamura, David Paik+ and Dean W. Felsher+.  Survival and Death Signals Can Predict Tumor Response to Therapy After Oncogene Inactivation.  Sci Transl Med 3 (2011) 103ra99**.  PMID: 21974937; PMCID: PMC3966995.

* - these authors contributed equally; and + - corresponding authors

Reem Malek*, Hailun Wang*, Kekoa Taparra, Phuoc T. Tran.  Therapeutic targeting of epithelial plasticity programs – Focus on the epithelial-mesenchymal transition.  Cells Tissues Organs 203 (2017) 114-127. PMID: 28214899.  PMCID: PMC5375029.

* - these authors contributed equally.

Jeffrey J. Tosoian, Michael A. Gorin, Ashley E. Ross, Kenneth J. Pienta, Phuoc T. Tran, Edward M. Schaeffer. Oligometastatic Prostate Cancer: Definitions, Clinical Outcomes, and Treatment Considerations. Nat Rev Urol 14 (2017) 15-25. PMID: 27725639.

Kekoa Taparra*, Hailun Wang*, Reem Malek*, Audrey Lafargue, Mustafa A. Barbhuiya, Xing Wang, Brian W. Simons, Matthew Ballew, Katriana Nugent, Jennifer Groves, Russell D. Williams, Takumi Shiraishi, James Verdone, Gokben Yildirir, Roger Henry, Bin Zhang, John Wong, Ken K. Wang, Barry D. Nelkin, Kenneth J. Pienta, Dean Felsher, Natasha E. Zachara+, Phuoc T. Tran+.  O-GlcNAcylation is required for mutant KRAS-induced lung tumorigenesis. J Clin Invest 128 (2018) 4924-4937**. PMID 30130254.  PMCID: PMC6205381.

* - these authors contributed equally; and + - corresponding authors

** - Highlighted in Cancer Res – Breaking Advances

Ryan Phillips, William Yue Shi, Matthew Deek, Noura Radwan, Su Jin Lim, Emmanuel S. Antonarakis, Steven P. Rowe, Ashley Ross, Michael A. Gorin, Curtiland Deville, Stephen C Greco, Hailun Wang, Samuel R. Denmeade, Channing J. Paller, Shirl Dipasquale, Theodore L. DeWeese, Daniel Y. Song, Hao Wang, Michael A. Carducci, Kenneth J. Pienta, Martin G. Pomper, Adam P. Dicker, Mario A. Eisenberger, Ash A. Alizadeh, Maximilian Diehn, Phuoc T. Tran.  Outcomes of Observation versus stereotactic ablative RadiatIon for OLigometastatic prostate CancEr – The ORIOLE Phase 2 Randomized Clinical Trial. JAMA Oncol 6(2020) 650-659**. PMID 32215577. PMCID: PMC7225913.

** - Editorial in JAMA Oncol, Ranked by Altmetric in top 10% of JAMA Oncol papers & Highlighted in Cancer Discovery & Nat Rev Urol

Academic Affiliations & Courses

Graduate Program Affiliation

Graduate Program in Cellular and Molecular Medicine

Activities & Honors


  • Fellow, Henry S. Kaplan Research, 2007
  • Alpha Omega Alpha Honor Medical Society Alumni Award, Oregon Health & Sciences University Chapter, 2013
  • Fellow, Parker B. Francis, 2008 - 2011
  • Fellow, Radiological Society of North America Research, 2008
  • John Muir College Caledonian Honor Society, University of California, 1995
  • 1R01CA166348-01A1, National Cancer Institute , 2013 - 2018
  • Sidney Kimmel Translational Scholar Award, 2013 - 2015
  • Patrick C. Walsh Prostate Cancer Research Fund Award, 2013 - 2014
  • Early Career Achievement Award, Oregon Health & Sciences University School of Medicine Alumni Association , 2013
  • Research Scholar, American Cancer Society , 2012 - 2016
  • Uniting Against Lung Cancer Award, 2012 - 2014
  • Included among Top Doctors, Baltimore Magazine, 2012
  • Educator of The Year, Association of Residents in Radiation Oncology (ARRO) , 2012
  • Prostate Cancer Physician Research Training Award, DoD , 2011 - 2016
  • The Phyllis and Brian L. Harvey Scholar - Patrick C. Walsh Prostate Cancer Research Fund Award, 2011 - 2013
  • Junior Faculty Career Research Training Award, ASTRO, 2009 - 2011
  • Malcolm A. Bagshaw Award, 2007
  • Methods in Clinical Cancer Research Workshop Scholarship, ASCO/AACR , 2007
  • Research Resident, Radiological Society of North America , 2006
  • Roentgen Resident Research Award, Radiological Society of North America , 2006
  • Deans Medical Student Research Award, OHSU, 2003
  • Molecular Hematology Research Training Fellow, OHSU, 1998 - 2001
  • Laurel Merit MD/PhD Scholar, OHSU, 1996 - 2003
  • Graduated magna cum laude, University of California, 1996
  • Regents Scholar, University of California, 1995 - 1996
  • Johns Hopkins Catalyst Award, 2015
  • ASCO Leadership Development Program, 2015
  • Movember Foundation-PCF Challenge Award, 2015
  • Johns Hopkins Discovery Award, 2016 - 2017
  • 1R21CA223403-01-01, National Cancer Institute, 2018
  • 1U01CA212007-01A1, National Cancer Institute, 2018
  • 1U01CA231776-01, National Cancer Institute, 2018


  • Alpha Omega Alpha Honor Medical Society , 2013
  • American Association for Cancer Research , 2007
  • American College of Radiation Oncology , 2005
  • American College of Radiology, 2004
  • American Society for Radiation Oncology, 2004
  • American Society of Clinical Oncology , 2007
  • American Thoracic Society, 2008 - 2012
  • Radiation Research Society , 2011
  • Radiological Society of North America , 2004
  • The EMT International Association , 2011
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