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Peter C.M. Van Zijl, Ph.D.

Headshot of Peter C.M. Van Zijl
  • Chief, Neuroscience, Division of MR Research, Department of Radiology and Radiological Science
  • Professor of Radiology and Radiological Science

Research Interests

Magnetic resonance imaging (MRI) technology development; Noninvasive imaging of metabolism; physiology and function; Development of bioorganic biodegradable MRI contrast agents; Application of MRI to brain development; neurodegeneration; stroke; Cancer ...read more

Background

Peter C.M. van Zijl, Ph.D., is a Professor in the Division of MR Research within the Johns Hopkins Medicine Department of Radiology and Radiological Science. He serves as Chief of the division’s Neuroscience section.

A researcher who specializes in brain imaging, Dr. van Zijl has spent his career developing novel magnetic resonance (MR) imaging and nuclear MR technologies and applying them to basic-science problems and clinical disease.

He is the Founding Director of the Johns Hopkins-affiliated F.M. Kirby Research Center for Functional Brain Imaging at the Kennedy Krieger Institute. He joined the Johns Hopkins faculty in 1992.

Dr. van Zijl earned a Ph.D. in mathematics and physics from The Netherlands’ Free University in Amsterdam, from which he also holds an M.S. in inorganic chemistry and a B.S. in chemistry.

He completed his post-doctoral work in chemistry at Carnegie Mellon University and in magnetic resonance imaging (MRI) and spectroscopy (MRS) at the NIH National Cancer Institute.

Dr. van Zijl has published more than 230 reviewed articles and serves as the principal investigator for a number of ongoing National Institutes of Health (NIH)-funded studies.

A Fellow of the International Society for Magnetic Resonance in Medicine, Dr. van Zijl is a member of many scientific advisory boards, NIH review panels and editorial boards. He also serves as the associate editor of Magnetic Resonance in Medicine.

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Titles

  • Chief, Neuroscience, Division of MR Research, Department of Radiology and Radiological Science
  • Professor of Radiology and Radiological Science
  • Professor of Oncology

Departments / Divisions

Centers & Institutes

Education

Additional Training

  • MRI and MRS, National Cancer Institute, National Institutes of Health, Bethesda, MD, 1990; Carnegie Mellon University, Pittsburgh, PA, 1987, Chemistry

Research & Publications

Research Summary

Dr. van Zijl has devoted his career to developing novel magnetic resonance imaging (MRI) and nuclear MR technologies and applying them to basic-science problems and clinical disease.

He has developed methods for MR spectroscopy (MRS) and MRS imaging; diffusion tensor imaging (DTI) and axonal mapping; physiological imaging (blood flow, blood volume and blood oxygenation); glucose metabolism measurement; and the study of magnetization-transfer processes.

Dr. van Zijl has contributed to the understanding of the blood-oxygen-level- dependent (BOLD) mechanism underlying functional MR imaging—and helped develop the capability to image endogenous signals of cellular proteins and peptides.

He is currently working to develop novel technologies for high-field MRI in humans and animals, which includes developing new biodegradable contrast agents and molecular image markers. He is also the principal investigator of a National Research Resource Center that develops MR and MRS technologies and makes them available to interested centers, scientists and clinicians.

Lab

Lab Website: Peter van Zijl Laboratory

Selected Publications

View all on PubMed

Chen L, Schär M, Chan KWY, Huang J, Wei Z, Lu H, Qin Q, Weiss RG, van Zijl PCM, Xu J. In vivo imaging of phosphocreatine with artificial neural networks. Nat Commun. 2020 Feb 26;11(1):1072. doi: 10.1038/s41467-020-14874-0.

Li W, van Zijl PCM. Quantitative theory for the transverse relaxation time of blood water. NMR Biomed. 2020 May;33(5):e4207. doi: 10.1002/nbm.4207. Epub 2020 Feb 5.

 

Zhou Y, van Zijl PCM, Xu X, Xu J, Li Y, Chen L, Yadav NN. Magnetic resonance imaging of glycogen using its magnetic coupling with water. Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):3144-3149. doi: 10.1073/pnas.1909921117. Epub 2020 Jan 30.

Zhou Y, van Zijl PCM, Xu X, Xu J, Li Y, Chen L, Yadav NN. Magnetic resonance imaging of glycogen using its magnetic coupling with water. Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):3144-3149. doi: 10.1073/pnas.1909921117. Epub 2020 Jan 30.

Leigh R, Knutsson L, Zhou J, van Zijl PC. Imaging the physiological evolution of the ischemic penumbra in acute ischemic stroke. J Cereb Blood Flow Metab. 2018 Sep;38(9):1500-1516. doi: 10.1177/0271678X17700913. Epub 2017 Mar 27

Activities & Honors

Honors

  • Gold Medal, 2007
  • Established Investigator Award, 1995
  • Laukien Award, Experimental NMR Conference, 2016
  • Fellow, International Society of Magnetic Resonance (ISMAR), 2012
  • Gold Medal, International Society of Magnetic Resonance in Medicine (ISMRM), 2007
  • Fellow, International Society of Magnetic Resonance in Medicine (ISMRM), 2004
  • Distinguished Investigator, Academy of Radiology Research, 2012

Memberships

  • International Society of Cerebral Blood Flow and Metabolism
  • International Society of Magnetic Resonance in Medicine

Professional Activities

  • Board of Trustees, International Society for Magnetic Resonance in Medicine, 2000
  • Chair, Experimental Nuclear Magnetic Resonance (NMR) Conference, 2003
  • Council, International Symposium on Mixed and Augmented Reality
  • Editorial Board, Journal of Cerebral Blood Flow & Metabolism
  • Editorial Board, Journal of Magnetic Resonance
  • Editorial Board, NMR in Biomedicine
  • Executive Committee, Experimental Nuclear Magnetic Resonance Conference, 1997
  • Associate Editor, Magnetic Resonance in Medicine
  • Deputy Editor, BME Frontiers
  • Executive Editor, Magnetic Resonance Open
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