Dr. Bottomley’s research focuses on the application of nuclear magnetic resonance (NMR) techniques to biophysical, biological and medical problems. He pursues the theoretical, experimental and technical development of NMR imaging (MRI); the development of methods for spatially localized spectroscopy (MRS) and the measurement of relaxation times, diffusion constants, metabolite concentrations, kinetic reaction rates, energy supply and work in biological tissues using NMR. He’s also interested in the application of these technologies to the noninvasive study of human disease, especially heart disease.
Specifically, Dr. Bottomley researches the effects of measurements of energy metabolites and metabolic fluxes with phosphorus (31P) and proton (1H) MRS in patients with ischemia, infarction and heart failure as well as sodium (23Na) MRI in patients with ischemic disease, and with cancer. Additionally, he investigates measurements of energy metabolites and metabolic fluxes with phosphorus (31P) and proton (1H) MRS in patients with ischemia, infarction and heart failure; sodium (23Na) MRI in patients with ischemic disease, and with cancer; stress testing for ischemia using 31P MRS; MRI detector coil design, phased-array detector coils including new strip detectors; and the development of new intravascular and internal MRI coils for imaging vascular and endothelial disease, and MRI-guided therapy delivery.
Qian D, El-Sharkawy AEM, Atalar E, Bottomley PA. “Interventional MRI: Tapering Improves the Forward-Looking Properties of the Loopless Antenna.” Magn Reson Med 2010; 63: 797-802. NIHMSID # 190764
Ruiz-Cabello J, Barnett BP, Bottomley PA, Bulte JWM. “Fluorine (19F) MRS and MRI indicine.” NMR in Biomedicine 2010 (in press).
Schar M, El-Sharkawy AEM, Weiss RG, Bottomley PA. “Triple Repetition Time Saturation Transfer (TRiST) 31P Spectroscopy for Measuring Human Creatine Kinase Reaction Kinetics.” Magnetic Resonance in Medicine; 63: 1493-1501.
Bottomley PA, Kumar A, Edelstein WA, Allen JM, Karmarkar PV. “Designing passive MRI-safe implantable conducting leads with electrodes.” Med Phys 2010; 37: 3828-3843.
Sathyanarayana S, Schar M, Kraitchman DL, Bottomley PA. “Real time MRI Endoscopy.” J Am Coll. Cardiol. Cardiovasc. Imag (in press, 2010).
Book: Bottomley PA, Griffiths JR. “Handbook of Magnetic Resonance Spectroscopy (MRS)”. John Wiley & Sons London. 1915 (in preparation).
Hinshaw WS, Bottomley PA, Holland GN. "Radiographic thin section image of the human wrist by nuclear magnetic resonance". Nature 1977; 270: 722-723.
Nunnally RL, Bottomley PA. "Assessment of pharmacological treatment of myocardial infarction by phosphorous-31 NMR with surface coils". Science 1981; 211: 177-180.
Bottomley PA, Hart HR, Edelstein, Schenck JF, Smith LS, Leue WM, Mueller OM, Redington RW. "NMR imaging/spectroscopy system to study both anatomy and metobolism". The Lancet 1983; ii (322), 273-274.
Bottomley PA, Foster TH, Argersinger RE, Pfeifer LM. “A review of normal tissue hydrogen NMR relaxation times and relaxation mechanisms: dependence on tissue type, NMR frequency, temperature, species, excision, and age." Med Phys 1984; 11: 425-448.
Bottomley PA, TH Foster, WM Leue. "Chemical imaging of the brain by NMR". Lancet 1984; I (323): 1120.
Bottomley PA. "Non-invasive study of high-energy phosphate metabolism in the human heart by depth resolved 31P NMR spectroscopy". Science 1985; 229: 769-772.
Bottomley PA, Weiss RG. Noninvasive MRS detection of localized creatine depletion in non-viable, infarcted myocardium. The Lancet 1998; 351: 714-718.
McCaffrey RJ, Cousins JP, Westervelt HJ, Martynowicz M, Remick SC, Szebenyi S, Wagle WA, Bottomley PA, Hardy CJ, Haase RF. Practice effects with the NIMH AIDS abbreviated neuropsychological battery. Arch Clin Neuropsych 1995; 10: 241-250.
Ouwerkerk R, Bottomley PA, Solaiyappan M, Spooner A, Tomaselli G, Wu KC, Weiss RG. Tissue sodium concentration in myocardial infarction in humans: A quantitative 23Na MR imaging study. Radiology 2008: 248; 88-96.
Bottomley PA*, Panjrath GS*, Lai S, Hirsch GA, Wu K, Najjar SS, Steinberg A, Gerstenblith G Weiss RG. Metabolic Rates of ATP Transfer Through Creatine Kinase (CK flux) Predict Clinical Heart Failure Events and Death. Science Transl Med 2013; 5: 215re3, pp1-8. DOI: 10.1126/scitranslmed.3007328
Weiss RG, Bottomley PA, Hardy CJ, Schulman SP, Gerstenblith. "31P NMR detected exercise changes in heart metabolism in patients with coronary artery disease". The 1989 American Heart Association Meeting, New Orleans Nov. 13-17, 1989. Circulation 1989; 80 (Suppl. II): II-588.
Weiss RG, Bottomley PA, Hardy CJ, Gerstenblith G. "Exercise-induced changes in cardiac high energy phosphates in patients with ischemic disease resolve after revascularization". The 1990 American Heart Association Meeting, Dallas, Nov. 12-15, 1990. Circulation 1990; 82 (SIII): III-684.
Hardy CJ, Bottomley PA, Roemer PB, Weiss RG, Darrow R. "NMR M-mode imaging and 31P spectroscopy of the human heart". In: Proceedings of the Cardiovascular Science and Technology Conference, Bethesda MD, Dec 12-14, 1992. Arlington VA: Association for the Advancement of Medical Instrumentation 1992; 200.
Pisacane VL, Bottomley PA, Chacko VP, Feldmesser HS,Wetsel GC. Space qualifiable magnetic resonance imaging system (poster). NASA Bioastronautics meeting, Houston TX, 18-19 Jan 2001.
Gabr RE, Schar M, Edelstein AD, Bottomley PA, Edelstein WA. MRI Dynamic Range: Theory and Measurement. Proc Intl Soc Mag Reson Med 2008; 16: 1129. NIHMSID # 602708.
Qian D, El-Sharkawy AEM, Bottomley PA, Edelstein WA. A Whole-Body RF Dosimeter for Independent SAR Measurement in MR Scanners. Proc Intl Soc Mag Reson Med 2013; 21: 2823. NIHMSID # 521450; PMC4211258.
Wang G, Erturk MA, Hegde SS, Bottomley PA. Automated classification of vessel disease based on high-resolution intravascular multi-parametric MRI. Proc Intl Soc Mag Reson Med. 2015; 23: 1659.