We focus on stem cell biology and cell fate engineering, with an emphasis on the development and diseases of the synovial joint. We invent computational tools to improve our understanding of development and to improve our ability to engineer cell fate and function, and we experimentally validate and apply these tools.
Lab Website: Cahan Laboratory
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Cahan P, Treutlein B. A conversation with ChatGPT on the role of computational systems biology in stem cell research. Stem Cell Reports. 22023 Jan 10;18(1):1-2 PMID: 36630899
Su EY*, Spangler A*,Bian Q, Kasamoto JY, Cahan P. Reconstruction of dynamic regulatory networks reveals signaling-induced topology changes associated with germ layer specification. Stem Cell Reports. 2022 Jan 10 PMID: 35090587
Peng D*, Gleyzer R*, Tai WH, Kumar P, Bian Q, Isaacs B, Rocha EL, Cai S, DiNapoli K, Huang FW, Cahan P. Evaluating the transcriptional fidelity of cancer models. Genome Medicine 2021 Apr 13;73. PMID: 33926541
Bian Q, Cheng YH, Wilson JP, Su EY, Kim DQ, Yoo S, Blackshaw S, Cahan P. A single cell transcriptional atlas of early synovial joint development. Development. 2020 June 20;147(14):dev185777 PMID: 32580935
Tan Y and Cahan P. SingleCellNet: A Computational Tool to Classify Single Cell RNA-Seq Data Across Platforms and Across Species. Cell Systems. 2019 Jul 17. pii: S2405-4712(19)30199-1. PMID: 31377170