01/01/2020 - 08/30/2022
CHIP-TB Trial (Child Home Initiated Preventive treatment for TB)
Funded by UNITAID and the IMPAACT4TB project, this cluster-randomized trial will compare home-based vs clinic-based evaluation and initiation of TB preventive therapy (3RH or 3HP) in child TB contacts less than 15 years of age in Ethiopia and South Africa. This includes pre and post-trial qualitative assessments and a cost-effectiveness evaluation.
Phase I/II Dose Finding, Safety and Tolerability Study of Daily Rifapentine Combined with Isoniazid (1HP) for Tuberculosis Prevention in Infants, Children and Adolescents
IMPAACT 2024 will study the PK and safety of 1HP, or one month of weekly rifapentine and isoniazid for TB prevention. This study will also assess drug interactions with dolutegravir and efavirenz in children living with HIV.
Nicole Salazar-Austin, Silvia Cohn, Sanjay Lala, Ziyaad Waja, Kelly E Dooley, Christopher J Hoffmann, Richard E Chaisson, Neil Martinson and the TSHEPISO Study Team. Isoniazid Preventive Therapy and Pregnancy Outcomes In HIV-Infected Women in the Tshepiso Cohort, Clinical Infectious Diseases
Nicole Salazar-Austin, Silvia Cohn, Grace Link Barnes, Molefi Tladi, Katlego Motlhaoleng, Catharina Swanepoel, Zarina Motala, Ebrahim Variava, Neil Martinson, Richard E Chaisson. Improving Tuberculosis Preventive Therapy Uptake: A Cluster-randomized Trial of Symptom-based Versus Tuberculin Skin Test-based Screening of Household Tuberculosis Contacts Less Than 5 Years of Age, Clinical Infectious Diseases Volume 70, Issue 8, 15 April 2020, Pages 1725–1732
Nicole Salazar-Austin, Jennifer Hoffmann, Silvia Cohn, Fildah Mashabela, Ziyaad Waja, Sanjay Lala, Christopher Hoffmann, Kelly E Dooley, Richard E Chaisson, Neil Martinson, TSHEPISO Study Team Poor Obstetric and Infant Outcomes in Human Immunodeficiency Virus-Infected Pregnant Women With Tuberculosis in South Africa: The Tshepiso Study, Clinical Infectious Diseases Volume 66, Issue 6, 15 March 2018, Pages 921–929