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Nestoras Nicolas Mathioudakis, M.D., M.H.S.

Headshot of Nestoras Nicolas Mathioudakis
  • Co-Medical Director of Johns Hopkins Medicine Diabetes Prevention & Education Program
  • Associate Professor of Medicine
Male

Languages: English, French, Greek

Expertise

Continuous Glucose Monitoring, Diabetes Mellitus, Diabetic Foot Ulcers, Endocrinology, Hypoglycemia, Insulin Pump, Insulinoma ...read more

Research Interests

Patient Safety and Quality; Inpatient Glucose Management; Type 2 Diabetes Mellitus; Diabetic Foot Ulcers; Type 1 Diabetes; Diabetes Technology; Machine Learning; Clinical Decision Support Systems ...read more

Locations

Johns Hopkins Medicine - Green Spring Station

10751 Falls Road
Falls Concourse Suite 412
Lutherville, MD 21093 map
Phone: 410-955-9270

Johns Hopkins Outpatient Center (now called Levi Watkins, Jr., M.D., Outpatient Center)

Appointment Phone: 410-955-9270
601 N. Caroline St.
Baltimore, MD 21287 map
Phone: 410-955-2908 | Fax: 410-614-9586

Background

Dr. Mathioudakis is an endocrinologist, researcher, educator, and clinical leader. He has been honored numerous times as a Baltimore Top Doc, recognizing his commitment to patient care and expertise in diabetes management.  He is a leading figure in diabetes research, having authored over 100 publications and contributed to consensus guidelines in the field.  His pioneering studies have provided substantial insights into health informatics approaches for diabetes prevention and management.

Dr. Mathioudakis graduated from the Johns Hopkins University School of Medicine and trained in Internal Medicine at Johns Hopkins Bayview Medical Center. He completed a fellowship in Endocrinology, Diabetes, & Metabolism at the Johns Hopkins Hospital. Dr. Mathioudakis received his Master of Health Science degree in clinical investigation from the Johns Hopkins Bloomberg School of Public Health in 2015.  In 2012, he became a member of the faculty in the Division of Endocrinology, Diabetes & Metabolism, where he served as the Clinical Director from 2016 to 2021.  His current role as the Co-Medical Director of the Baltimore Metropolitan Diabetes Regional Partnership allows him to lead a comprehensive statewide initiative aimed at increasing patient access to diabetes prevention and self-management training programs.

Dr. Mathioudakis is the Principal Investigator of several NIH-funded studies.  He is currently spearheading a clinical study to assess the effectiveness of a fully-automated diabetes prevention program compared to human coach-based diabetes prevention programs. Committed to ensuring equitable patient care, he is also leading a study to reduce racial disparities in access and use of advanced diabetes technologies.   He also serves as the Principal Investigator for the T1D Exchange Quality Improvement Collaborative at the Johns Hopkins Adult Diabetes Center, where he works with a national network of healthcare providers to enhance the care and outcome of people with type 1 diabetes.  

Dr. Mathioudakis holds a joint appointment in the Division of Biomedical Informatics and Data Science.  He has published extensively on machine learning and AI applications in diabetes, allowing him to integrate cutting-edge technology into medical practice, improving healthcare outcomes and patient management through data-driven insights.  Dr. Mathioudakis also served on the national Epic Endocrinology Specialty Steering Board for three years, where he played a pivotal role in defining the gold standard for electronic medical record adoption among endocrinology specialists across the country.  From 2020-2023, Dr. Mathioudakis served as a Chair of the Type 2 Diabetes Prognostics Working Group for the Precision Medicine Diabetes Initiative.  As part of an international team of experts, he has strived to advance precision medicine in diabetes care, paving the way for personalized treatment plans that can significantly improve patient outcomes.  

Beyond his clinical practice and research, Dr. Mathioudakis is deeply committed to the education of future healthcare professionals.  He is a frequent lecturer in various fields, including endocrinology, epidemiology, and data science.  

...read more

Titles

  • Co-Medical Director of Johns Hopkins Medicine Diabetes Prevention & Education Program
  • Lead, Diabetes Clinical Community, Armstrong Institute for Patient Safety and Quality
  • Co-Director, Multi-Disciplinary Diabetes Foot Wound Clinic
  • Associate Professor of Medicine

Departments / Divisions

Centers & Institutes

Education

Degrees

  • MD; Johns Hopkins University School of Medicine (2006)

Residencies

  • Internal Medicine; Johns Hopkins Bayview Medical Center (2009)

Fellowships

  • Endocrinology; Johns Hopkins University School of Medicine (2012)

Board Certifications

  • American Board of Internal Medicine (Endocrinology/Diabetes/Metabolism) (2011)
  • American Board of Internal Medicine (Internal Medicine) (2009)

Research & Publications

Research Summary

Our scientific contributions have been in the following areas:

  • Machine Learning, AI, and Precision Medicine.  Our lab has published extensively on machine learning and AI algorithms for the prediction of diabetes complications, glucose prediction, and insulin dosing. We have also evaluated AI-based interventions, such as digital diabetes prevention programs.
  • Diabetes Technology.   We have published several studies on decision support tools, continuous glucose monitors, continuous ketone monitors, and the access and use of diabetes technologies.
  • Diabetes Management and Outcomes.  Our lab has published extensively on diabetes outcomes (inpatient glucose control, diabetic foot ulcers, hypoglycemia).
  • Diabetic Foot Ulcers.  Based on results from a Johns Hopkins prospective cohort study, we have published numerous studies on outcomes of patients with diabetic foot ulcers, with unique contributions to the field related to the role of glycemic control in patients with this complication.
  • Health Services Research.  We have published on quality improvement/systems innovation approaches to diabetes care, healthcare disparities, and population health approaches to diabetes management.
  • Diabetes Prevention.  As PI on the Diabetes Prevention Program Outcomes Study and Co-Medical Director of our Diabetes Prevention and Education Program, we have published on interventions and outcomes for diabetes prevention.
  • Clinical Case Reports.  To share information vital to the practice of endocrinology, Dr. Mathioudakis has published several clinical case reports on diagnostic or management challenges.
  • Endocrinology.  We have published studies on various clinical topics in endocrinology, including pituitary tumors, vitamin D, insulin resistance syndromes, and insulinoma.

Lab

Our lab is focused on developing and evaluating clinical decision support systems, technology, and mHealth for diabetes prevention and management.  We leverage large electronic medical databases and use machine learning algorithms and artificial intelligence to identify patterns in clinical care associated with optimal clinical outcomes.  We are interested in understanding the role that advanced diabetes technologies can play in improving health outcomes for patients with diabetes.    

Lab Website: Nestoras Mathioudakis Lab

Technology Expertise Keywords

Machine Learning; Continuous Glucose Monitoring; Insulin Pumps

Clinical Trial Keywords

diabetes prevention

Clinical Trials

Selected Publications

View all on PubMed

Racial Disparities in Access and Use of Diabetes Technology Among Adult Patients With Type 1 Diabetes in a U.S. Academic Medical Center.  Kanbour S, Jones M, Abusamaan MS, Nass C, Everett E, Wolf RM, Sidhaye A, Mathioudakis N. Diabetes Care. 2023 Jan 1;46(1):56-64. doi: 10.2337/dc22-1055. PMID: 36378855

Development and Validation of a Machine Learning Model to Predict Near-Term Risk of Iatrogenic Hypoglycemia in Hospitalized Patients. Mathioudakis NN, Abusamaan MS, Shakarchi AF, Sokolinsky S, Fayzullin S, McGready J, Zilbermint M, Saria S, Golden SH. JAMA Netw Open. 2021 Jan 4;4(1):e2030913. doi: 10.1001/jamanetworkopen.2020.30913. PMID: 33416883 

Development and validation of a machine learning model for classification of next glucose measurement in hospitalized patients. Zale AD, Abusamaan MS, McGready J, Mathioudakis N. EClinicalMedicine. 2022 Feb 4;44:101290. doi: 10.1016/j.eclinm.2022.101290. eCollection 2022 Feb. PMID: 35169690 

Association of Hemoglobin A1cand Wound Healing in Diabetic Foot Ulcers. Fesseha BK, Abularrage CJ, Hines KF, Sherman R, Frost P, Langan S, Canner J, Likes KC, Hosseini SM, Jack G, Hicks CW, Yalamanchi S, Mathioudakis N. Diabetes Care. 2018 Jul;41(7):1478-1485. doi: 10.2337/dc17-1683. Epub 2018 Apr 16. PMID: 29661917

Contact for Research Inquiries

Email me

Academic Affiliations & Courses

Graduate Program Affiliation

  • Biomedical Informatics and Data Science
  • Epidemiology (Bloomberg School of Public Health)

Courses and Syllabi

  • Thyroid Disorders
    Johns Hopkins School of Nursing
    2012 - 2013
  • Diabetes Management
    Johns Hopkins Hospital Advanced Practice Providers
    2012 - 2012
  • Hyperglycemic Emergencies
    Johns Hopkins Bayview Medical Center Residency Program
    2012
  • Thyroid Nodules and Thyroid Cancer
    Johns Hopkins University School of Medicine
    2012 - 2012
  • Diabetes Mellitus
    Johns Hopkins Hospital Internal Medicine Basic Clerkship
    2012
  • Endocrinology (Genes to Society - Year 2 Course)
    Johns Hopkins University School of Medicine
    2012
  • Epidemiology (Genes to Society- Year 1 Course)
    Johns Hopkins University School of Medicine
    2018
  • Database Querying in Health (250.957)
    Biomedical Informatics and Data Science
    2021
  • Diabetes 101
    Johns Hopkins Bloomberg School of Public Health
    2019

Activities & Honors

Honors

  • Phi Beta Kappa, Johns Hopkins University, 1999
  • Leonie Shorey Scholar, Johns Hopkins University, 2001
  • Departmental Honors, Johns Hopkins University, 2001
  • First Place Oral Clinical Vignette, American College of Physicians, 2009
  • Endocrinology Mentor of the Year Award, 2012
  • Elected to Epic Endocrinology National Steering Board, Epic, 2017
  • Baltimore Top Doctor 2018, Endocrinology, 2018
  • Nominated Clinical Member to the national Merit-Based Incentive Program (MIPS) of the Center for Medicare and Medicaid Service (CMS) for development of two outpatient diabetes quality measures, 2018
  • Elected Member, Alpha Omega Alpha Medical Honor Society, 2020
  • Baltimore Top Doctor, Diabetes Care, 2020
  • Baltimore Top Doctor, Diabetes Care, 2021
  • Co-Chair, Type 2 Diabetes Prognostics Working Group, American Diabetes Association Precision Medicine Diabetes Initiative, 2020 - 2023

Memberships

  • American Association of Clinical Endocrinologists (AACE)
  • American Diabetes Association (ADA), 2012
  • Endocrine Society, 2011
  • PRIDE (Planning Research in Inpatient Diabetes), 2012
  • Journal of Diabetes and Its Complications, 2020

    Editorial Board Member

Professional Activities

  • Attending Physician, Endocrinology Consultation Service, 2012
  • Consulting physician, General Endocrinology Outpatient Clinic, 2012
  • Diabetes Center Outpatient Clinics
  • Education (medical students, residents, fellows)
  • Preceptor, Johns Hopkins Endocrinology, Diabetes & Metabolism Fellows' Outpatient Clinic
  • Clinical Director, Division of Endocrinology, Diabetes and Metabolism, 2016 - 2021

Videos & Media

Play Video:

Johns Hopkins Diabetes Prevention and Education Program

Lectures and Presentations

  • Ectopic ACTH syndrome
    Maryland Endocrine Society Meeting, Baltimore, MD (02/01/2011)
    Union Memorial Hospital
  • Prevention of Type 2 Diabetes Mellitus in 2013
    Lecture to Employees and clients of Butterfield Bank, Bermuda (05/01/2013)
    Butterfield Bank
  • Insulin Therapy in Type 2 Diabetes
    Department of Medicine Grand Rounds, Kuwait (09/01/2012)
    Al Adan Hospital
  • Principles in Insulin Pump Management
    Department of Medicine Grand Rounds, Kuwait (09/01/2012)
    Al Adan Hospital
  • Diabetic Nephropathy: Current Understanding and Standards of Care
    Endocrine Grand Rounds, Baltimore, MD (10/01/2012)
    Johns Hopkins Hospital
  • Prevention of Type 2 Diabetes in 2013
    Medical Grand Rounds, San Fernando, Trinidad and Tobago (01/01/2012)
    San Fernando General Hospital
  • Top 10 Inpatient Glycemic Management Errors at Johns Hopkins Hospital in 2012
    Endocrine Grand Rounds, Baltimore, MD (04/01/2013)
    Johns Hopkins Hospital
  • Medical Strategies for the Diabetic Foot Ulcer
    Endocrine Grand Rounds, Baltimore, MD (10/01/2013)
    Johns Hopkins Hospital
  • Insulin Therapy in Type 2 Diabetes
    Department of Medicine Grand Rounds, Kuwait (01/01/2012)
    Al Adan Hospital
  • Principles in Insulin Pump Management
    Department of Medicine Grand Rounds, Kuwait (01/01/2012)
    Al Adan Hospital
  • Diabetic Nephropathy, Current Understanding and Standards of Care
    Endocrine Grand Rounds, Baltimore (01/01/2012)
    Johns Hopkins Hospital
  • Prevention of Type 2 Diabetes in 2013
    Medical Grand Rounds, San Fernando (01/01/2012)
    San Fernando General Hospital
  • Top 10 Inpatient Glycemic Management Errors at Johns Hopkins Hospital in 2012
    Endocrine Grand Rounds, Baltimore (01/01/2013)
    Johns Hopkins Hospital
  • Medical Strategies for the Diabetic Foot Ulcer
    Endocrine Grand Rounds, Baltimore (01/01/2013)
    Johns Hopkins Hospital
  • Insulin-Associated Hypoglycemia
    Invited Talk, Grand Rounds, Department of Medicine, Johns Hopkins Hospital (01/15/2016)
    Johns Hopkins University
  • Insulin-Associated Hypoglycemia in the Hospital
    Invited Talk, Grand Rounds, Medical Grand Rounds, Bayview Medical Center (01/26/2016)
    Johns Hopkins University
  • Diabetic Foot Ulcers: Prevention and Treatment Strategies
    Invited Talk, Grand Rounds, Endocrine Grand Rounds, Johns Hopkins Hospital (01/28/2016)
    Johns Hopkins University
  • Weight Loss Strategies for Diabetes Prevention and Management
    Invited Talk, CME, Maryland Chapter Scientific Meeting, Ellicott City, Maryland (02/17/2017)
    American College of Physicians
  • Predicting Insulin-Associated Hypoglycemia in Hospitalized Patients- Moving Towards a Real-Time Alerting System
    Invited Talk, Grand Rounds, Endocrine Grand Rounds, Johns Hopkins Hospital (02/07/2018)
    Johns Hopkins University
  • Racial Differences of AKI of Hospitalized Adults with Diabetes
    Invited Talk, Scientific Meeting, American Association of Clinical Endocrinologists Scientific Meeting, Nashville, TN (05/07/2015)
    AACE
  • Development of an Ambulatory Medication Smartset
    Invited Talk, Scientific Meeting, Epic User Group Meeting, Verona, WI (09/19/2016)
    Epic
  • Glucose Management in the Hospital: From Clinical Care to Systems Interventions
    Invited Talk, Scientific Meeting, Quality Improvement Workshop of Inpatient Blood Glucose Management, Beijing, China (03/20/2015)
    Peking University
  • Real-Time Model of Insulin-Associated Hypoglycemia
    Invited Talk, Scientific Meeting, 77th Scientific Session, San Diego, CA (06/09/2017)
    American Diabetes Association
  • CGM started after patient arrives at hospital: Cost-Effectiveness Considerations, Data Science and Technology
    Invited talk, National Scientific Meeting, Hospital Diabetes Meeting, Virtual (04/01/2019)
    Diabetes Science and Technology
  • High Value Care for Diabetes Prevention
    Invited Talk, National Meeting, High Value Practice Academic Alliance, Baltimore, Maryland (10/10/2021)
  • Machine Learning Glycemic Prediction for the Hospital Using EHR Data
    Invited Talk, National Conference, Hospital Diabetes Meeting, Virtual Meeting (04/04/2022)
    Diabetes Science and Technology
  • Working with Big Data: Machine Learning Applications in Endocrinology
    Webinar, Endocrine Society Webinar, Virtual (05/01/2022)
    Endocrine Society
  • Diabetes Self-Management Training: A High Value Standard of Care
    Invited Talk, National Conference, Architecture of High Value Practice Academic Alliance, Baltimore, Maryland (10/06/2022)
  • Antihyperglycemic Agents and Cardiovascular Outcomes
    Invited Talk, International Meeting, Cardiometablic Conference, Dhahran, Saudi Arabia (10/01/2018)
    Saudi Aramco
  • Prevention of Insulin-Associated Hypoglycemia with a Real-Time Infomatics Alert
    Invited Talk, International Conference, 5th Annual International Symposium on Diabetes, Athens, Greece (05/10/2019)
    Athens Institute for Education and Research
  • Management of Steroid-Induced Hyperglycemia
    Invited Talk, International Meeting, International Conference of Endocrinology and Diabetes, Virtual (02/01/2021)
    Saudi Arabia Endocrine Society
  • Diabetes Prevention Program: Current and Future Perspectives
    Invited Talk, International Meeting, 8th International Conference of Endocrinology and Diabetes, Virtual (02/10/2021)
    Saudi Arabia Endocrine Society
  • Preventing Iatrogenic Hypoglycemia in the Hospital: Leveraging the Power of Big Data
    Invited Talk, International Meeting, 8th International Conference of Endocrinology and Diabetes, Virtual (02/01/2021)
    Saudia Arabia Endocrine Society
  • Use of Machine Learning in Clinical Research
    Webinar, Webinar, Shanghai University of Medicine and Health Sciences Webinar, Virtual (05/01/2022)
    Shanghai University of Medicine and Health Sciences, Shanghai, China
  • Use of Machine Learning in Clinical Research
    Webinar, Longua Hospital Webinar, Virtual (09/01/2022)
    Longhua Hospital, Shanghai, China

Recent News Articles and Media Coverage

  • Physicians must clearly inform patients with diabetes risks for ketoacidosis when using SGLT2 inhibitors, Healio (September 5, 2016)
  • Hospitals work to improve inpatient diabetes management, Healio (July 2015)
  • Five Terrifying Signs of Diabetes You Probably Don't Know About,  MensHealth (April 2018)
  • Researcher Spotlight: Nestoras Mathioudakis, MD MHS, Practical Diabetology (January 2019)
  • Hemoglobin A1C and Wound Healing unrelated in diabetic foot ulcers, Endocrinology Advisor (May, 2018)
  • What are ketones? Prevention.com (June, 2018)
  • Insulin is getting so expensive that people with diabetes are switching to older versions of the drug.  It's having deadly consequences, INSIDER (August 16, 2019)
  • Johns Hopkins, University of Maryland Medical Center Team Up to Tackle Diabetes in Baltimore, NewsWise (November 2020)
  • Population Health Initiative to Improve Chronic Disease Management, Health IT Analytics (November 2020)
  • Out of Control: America's Losing Battle Against Diabetes, Reuters (August 2021)
  • Diabetes Care "On Air" Podcast, Diabetes Journals (January 3, 2023)
  • Meet the Expert: Asking the ‘Why?’ Behind Racial Disparities in Diabetes Tech Use, T1D Exchange (April 14, 2023)

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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