Nestoras Nicolas Mathioudakis, M.D., M.H.S.

Headshot of Nestoras Nicolas Mathioudakis
  • Co-Medical Director of Johns Hopkins Medicine Diabetes Prevention & Education Program
  • Associate Professor of Medicine

Languages: English, French, Greek


Continuous Glucose Monitoring, Diabetes Mellitus, Diabetic Foot Ulcers, Endocrinology, Hypoglycemia, Insulin Pump, Insulinoma more

Research Interests

Patient Safety and Quality; Inpatient Glucose Management; Type 2 Diabetes Mellitus; Diabetic Foot Ulcers; Type 1 Diabetes; Diabetes Technology; Machine Learning; Clinical Decision Support Systems more


Johns Hopkins Medicine - Green Spring Station

10751 Falls Road
Falls Concourse Suite 412
Lutherville, MD 21093
Phone: 410-955-9270
Johns Hopkins Medicine - Green Spring Station - Google Maps

Johns Hopkins Outpatient Center (now called Levi Watkins, Jr., M.D., Outpatient Center)

Appointment Phone: 410-955-9270
601 N. Caroline St.
Baltimore, MD 21287
Phone: 410-955-2908 | Fax: 410-614-9586
Johns Hopkins Outpatient Center (now called Levi Watkins, Jr., M.D., Outpatient Center) - Google Maps


Dr. Mathioudakis, an endocrinologist and researcher, has a strong focus on diabetes management and patient care, recognized through awards like the Baltimore Top Doc. He has contributed significantly to diabetes research, authoring over 100 publications and participating in the development of consensus guidelines in the field. His studies have offered valuable insights into using health informatics for diabetes prevention and management.

After graduating from the Johns Hopkins University School of Medicine and completing his training in Internal Medicine and a fellowship in Endocrinology, Diabetes, & Metabolism, Dr. Mathioudakis joined the faculty in the Division of Endocrinology, Diabetes & Metabolism in 2012. He earned a Master of Health Science in clinical investigation in 2015 and was the Clinical Director of the Division of Endocrinology from 2016 to 2021. Currently, he co-directs the Baltimore Metropolitan Diabetes Regional Partnership, focusing on improving access to diabetes prevention and management programs.

Involved in several NIH-funded studies, Dr. Mathioudakis is researching the effectiveness of automated diabetes prevention programs and strategies to reduce racial disparities in diabetes technology access. He also collaborates nationally to enhance care for people with type 1 diabetes. 

Holding a joint appointment in the Division of Biomedical Informatics and Data Science, Dr. Mathioudakis integrates machine learning and AI in diabetes research. He has served on the national Epic Endocrinology Specialty Steering Board and chaired the Type 2 Diabetes Prognostics Working Group for the Precision Medicine Diabetes Initiative. Committed to education, he frequently lectures on endocrinology, epidemiology, and health informatics. more


  • Co-Medical Director of Johns Hopkins Medicine Diabetes Prevention & Education Program
  • Lead, Diabetes Clinical Community, Armstrong Institute for Patient Safety and Quality
  • Co-Director, Multi-Disciplinary Diabetes Foot Wound Clinic
  • Associate Professor of Medicine

Departments / Divisions

Centers & Institutes



  • MD; Johns Hopkins University School of Medicine (2006)


  • Internal Medicine; Johns Hopkins Bayview Medical Center (2009)


  • Endocrinology; Johns Hopkins University School of Medicine (2012)

Board Certifications

  • American Board of Internal Medicine (Endocrinology/Diabetes/Metabolism) (2011)

Research & Publications


Our lab is focused on developing and evaluating clinical decision support systems, technology, and mHealth for diabetes prevention and management.  We leverage large electronic medical databases and use machine learning algorithms and artificial intelligence to identify patterns in clinical care associated with optimal clinical outcomes.  We are interested in understanding the role that advanced diabetes technologies can play in improving health outcomes for patients with diabetes.    

Lab Website: Nestoras Mathioudakis Lab

Technology Expertise Keywords

Machine Learning; Continuous Glucose Monitoring; Insulin Pumps

Clinical Trial Keywords

diabetes prevention

Clinical Trials

Selected Publications

View all on PubMed

Racial Disparities in Access and Use of Diabetes Technology Among Adult Patients With Type 1 Diabetes in a U.S. Academic Medical Center.  Kanbour S, Jones M, Abusamaan MS, Nass C, Everett E, Wolf RM, Sidhaye A, Mathioudakis N. Diabetes Care. 2023 Jan 1;46(1):56-64. doi: 10.2337/dc22-1055. PMID: 36378855

Development and Validation of a Machine Learning Model to Predict Near-Term Risk of Iatrogenic Hypoglycemia in Hospitalized Patients. Mathioudakis NN, Abusamaan MS, Shakarchi AF, Sokolinsky S, Fayzullin S, McGready J, Zilbermint M, Saria S, Golden SH. JAMA Netw Open. 2021 Jan 4;4(1):e2030913. doi: 10.1001/jamanetworkopen.2020.30913. PMID: 33416883 

Development and validation of a machine learning model for classification of next glucose measurement in hospitalized patients. Zale AD, Abusamaan MS, McGready J, Mathioudakis N. EClinicalMedicine. 2022 Feb 4;44:101290. doi: 10.1016/j.eclinm.2022.101290. eCollection 2022 Feb. PMID: 35169690 

Association of Hemoglobin A1cand Wound Healing in Diabetic Foot Ulcers. Fesseha BK, Abularrage CJ, Hines KF, Sherman R, Frost P, Langan S, Canner J, Likes KC, Hosseini SM, Jack G, Hicks CW, Yalamanchi S, Mathioudakis N. Diabetes Care. 2018 Jul;41(7):1478-1485. doi: 10.2337/dc17-1683. Epub 2018 Apr 16. PMID: 29661917

Contact for Research Inquiries

Email me

Academic Affiliations & Courses

Graduate Program Affiliation

  • Biomedical Informatics and Data Science
  • Epidemiology (Bloomberg School of Public Health)

Courses and Syllabi

  • Epidemiology (Genes to Society- Year 1 Course)
    Johns Hopkins University School of Medicine
  • Database Querying in Health (250.957)
    Biomedical Informatics and Data Science
  • Diabetes 101
    Johns Hopkins Bloomberg School of Public Health
  • TIME: Clinical Informatics
    Johns Hopkins University School of Medicine

Activities & Honors


  • Phi Beta Kappa, Johns Hopkins University, 1999
  • Leonie Shorey Scholar, Johns Hopkins University, 2001
  • Departmental Honors, Johns Hopkins University, 2001
  • First Place Oral Clinical Vignette, American College of Physicians, 2009
  • Endocrinology Mentor of the Year Award, 2012
  • Elected to Epic Endocrinology National Steering Board, Epic, 2017
  • Baltimore Top Doctor 2018, Endocrinology, 2018
  • Nominated Clinical Member to the national Merit-Based Incentive Program (MIPS) of the Center for Medicare and Medicaid Service (CMS) for development of two outpatient diabetes quality measures, 2018
  • Elected Member, Alpha Omega Alpha Medical Honor Society, 2020
  • Baltimore Top Doctor, Diabetes Care, 2020, 2021, 2023
  • Co-Chair, Type 2 Diabetes Prognostics Working Group, American Diabetes Association Precision Medicine Diabetes Initiative, 2020 - 2023


  • American Association of Clinical Endocrinologists (AACE)
  • American Diabetes Association (ADA), 2012
  • Endocrine Society, 2011
  • PRIDE (Planning Research in Inpatient Diabetes), 2012
  • Journal of Diabetes and Its Complications, 2020

    Editorial Board Member

Professional Activities

  • Attending Physician, Endocrinology Consultation Service, 2012
  • Consulting physician, General Endocrinology Outpatient Clinic, 2012
  • Diabetes Center Outpatient Clinics
  • Education (medical students, residents, fellows)
  • Preceptor, Johns Hopkins Endocrinology, Diabetes & Metabolism Fellows' Outpatient Clinic
  • Clinical Director, Division of Endocrinology, Diabetes and Metabolism, 2016 - 2021

Videos & Media

Lectures and Presentations

  • Glucose Management in the Hospital: From Clinical Care to Systems Interventions
    Invited Talk, Scientific Meeting, Quality Improvement Workshop of Inpatient Blood Glucose Management, Beijing, China (03/20/2015)
    Peking University
  • Real-Time Model of Insulin-Associated Hypoglycemia
    Invited Talk, Scientific Meeting, 77th Scientific Session, San Diego, CA (06/09/2017)
    American Diabetes Association
  • High Value Care for Diabetes Prevention
    Invited Talk, National Meeting, High Value Practice Academic Alliance, Baltimore, Maryland (10/10/2021)
  • Machine Learning Glycemic Prediction for the Hospital Using EHR Data
    Invited Talk, National Conference, Hospital Diabetes Meeting, Virtual Meeting (04/04/2022)
    Diabetes Science and Technology
  • Working with Big Data: Machine Learning Applications in Endocrinology
    Webinar, Endocrine Society Webinar, Virtual (05/01/2022)
    Endocrine Society
  • Diabetes Self-Management Training: A High Value Standard of Care
    Invited Talk, National Conference, Architecture of High Value Practice Academic Alliance, Baltimore, Maryland (10/06/2022)
  • Antihyperglycemic Agents and Cardiovascular Outcomes
    Invited Talk, International Meeting, Cardiometablic Conference, Dhahran, Saudi Arabia (10/01/2018)
    Saudi Aramco
  • Prevention of Insulin-Associated Hypoglycemia with a Real-Time Infomatics Alert
    Invited Talk, International Conference, 5th Annual International Symposium on Diabetes, Athens, Greece (05/10/2019)
    Athens Institute for Education and Research
  • Management of Steroid-Induced Hyperglycemia
    Invited Talk, International Meeting, International Conference of Endocrinology and Diabetes, Virtual (02/01/2021)
    Saudi Arabia Endocrine Society
  • Diabetes Prevention Program: Current and Future Perspectives
    Invited Talk, International Meeting, 8th International Conference of Endocrinology and Diabetes, Virtual (02/10/2021)
    Saudi Arabia Endocrine Society
  • Preventing Iatrogenic Hypoglycemia in the Hospital: Leveraging the Power of Big Data
    Invited Talk, International Meeting, 8th International Conference of Endocrinology and Diabetes, Virtual (02/01/2021)
    Saudia Arabia Endocrine Society
  • Use of Machine Learning in Clinical Research
    Webinar, Webinar, Shanghai University of Medicine and Health Sciences Webinar, Virtual (05/01/2022)
    Shanghai University of Medicine and Health Sciences, Shanghai, China
  • AI in Health and Medicine: The State of the Field
    Lecture, American Thyroid Association annual meeting at the plenary session on Artificial Intelligence, Washington, D.C. (09/23/2023)

Recent News Articles and Media Coverage

  • Physicians must clearly inform patients with diabetes risks for ketoacidosis when using SGLT2 inhibitors, Healio (September 5, 2016)
  • Hospitals work to improve inpatient diabetes management, Healio (July 2015)
  • Five Terrifying Signs of Diabetes You Probably Don't Know About,  MensHealth (April 2018)
  • Researcher Spotlight: Nestoras Mathioudakis, MD MHS, Practical Diabetology (January 2019)
  • Hemoglobin A1C and Wound Healing unrelated in diabetic foot ulcers, Endocrinology Advisor (May, 2018)
  • What are ketones? (June, 2018)
  • Insulin is getting so expensive that people with diabetes are switching to older versions of the drug.  It's having deadly consequences, INSIDER (August 16, 2019)
  • Johns Hopkins, University of Maryland Medical Center Team Up to Tackle Diabetes in Baltimore, NewsWise (November 2020)
  • Population Health Initiative to Improve Chronic Disease Management, Health IT Analytics (November 2020)
  • Out of Control: America's Losing Battle Against Diabetes, Reuters (August 2021)
  • Diabetes Care "On Air" Podcast, Diabetes Journals (January 3, 2023)
  • Meet the Expert: Asking the ‘Why?’ Behind Racial Disparities in Diabetes Tech Use, T1D Exchange (April 14, 2023)
  • AI Takes Center Stage at the American Thyroid Association’s Annual Meeting, Doximity (October 9, 2023)
  • Diabetes Deconstructed, Episode 30, The Johns Hopkins Patient Guide to Diabetes
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