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Mohan Kumar Krishnan, Ph.D., M.S.

Headshot of Mohan Kumar Krishnan
  • Assistant Professor of Pediatrics

Research Interests

Neonatal anemia; murine RBC-transfusion; Necrotizing Enterocolitis; Retinopathy of Prematurity; retinal inflammation; Leukocyte Biology and functions ...read more

Background

Dr. Krishnan, Assistant Professor, received his Ph.D. in Biochemistry-Biotechnology from the University of Madras in 2008.  He completed his postdoctoral fellowship in the Department of Pediatrics at the University of Alabama at Birmingham and Department of Pediatrics, University of Illinois at Chicago. After he worked as Research Associate in Department of Pediatrics at the University of South Florida, Dr. Krishnan joined the faculty at JHU in May 2018. His lab investigates the pathophysiology of Transfusion-associated Necrotizing Enterocolitis (TANEC) and Systemic Inflammatory Response Syndrome (SIRS) in premature infants who are at high risk of anemia and heavily transfused.  Dr. Krishnan is dedicated to understanding the role of monocyte/macrophage in the neonate and investigating their inflammatory phenotype, function during anemia and/or RBC-transfusion associated NEC and SIRS.

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Titles

  • Assistant Professor of Pediatrics

Departments / Divisions

Education

Degrees

  • B.S.; University of Madras (India) (1997)
  • M.S.; University of Madras (India) (2001)
  • Ph.D.; University of Madras (India) (2008)

Research & Publications

Research Summary

Mohan Krishnan’s research interests focus on the inflammatory mechanisms of neonatal necrotizing enterocolitis (NEC), specifically on red blood cell (RBC) transfusion-associated NEC. Dr. Krishnan is currently the PI of NIH-R21 project entitled "RBC transfusion in anemic neonates leads to systemic inflammatory response syndrome" and PI  (interim) of two NIH-R01 project entitled "Effect of Platelet Transfusions on Neonatal Intestinal Injury". Dr. Krishnan is interested in the role of monocyte/macrophage in NEC pathogenesis, developed a preclinical mouse model of RBC transfusion-associated NEC and recently published in Nature Communications. This novel model of transfusion-associated NEC is the first preclinical model of transfusion effects in the neonatal intestine and has been awarded a provisional patent. He laid the groundwork for these preclinical models to understand the mechanism(s) by which anemia-transfusion causing gut/systemic inflammation in neonates, a critical step in the development of novel anti-inflammatory therapies that can prevent/ameliorate tissue damage. By focusing on red blood cell biology and transfusion medicine, he increasingly appreciates shared molecular mechanisms driving transfusion-associated adverse effects such systemic inflammatory response syndrome (SIRS) and NEC. 

Selected Publications

View all on PubMed

MohanKumar K, Namachivayam K, Song T, Nithya S, Cha BJ, Mong E, Alves NG, Jain HT, Breslin JW, Torres BA, and Maheshwari A. Severe Anemia in Pre-Weaned Mice Increases Gut Mucosal Permeability by Disrupting Epithelial Adherens Junctions. American Journal of Physiology-Gastrointestinal and Liver Physiology 2020 Apr 1;318(4):G705-G716

Namachivayam K, MohanKumar K, Shores DR, Jain SK, Fundora J, Everett AD, He L, Pan H, Wickline SA and Maheshwari A. Targeted Inhibition of Thrombin attenuates murine neonatal Necrotizing Enterocolitis. Proc Natl Acad Soc 2020. 117(20):10958-10969

MohanKumar K, Namachivayam K, Song T, Cha BJ, Slate A, Hendrickson JE, Pan H Wickline SA, Oh JY, Patel RP, Torres BA, Maheshwari A. A Novel Murine Model of Necrotizing Enterocolitis Caused by Anemia and Red Blood Cell Transfusion. Nature Communications; 2019; Aug 2;10(1):3494. Doi: 10.1038/s41467-019-11199

MohanKumar K, Namachivayam K, Cheng F, Jiang RHY, Torres JF, Torres BA, Maheshwari A. Trinitrobenzene Sulfonic Acid-induced Intestinal Injury in Neonatal Mice Activates Transcriptional Networks Similar to those seen in Human Necrotizing Enterocolitis. Pediatric Research; 2017 Jan; 81 (1) : 99-112

MohanKumar K, Namachivayam K, Ho TTB, Torres BA, Ohls RK, Maheshwari A. Cytokines and Growth Factors in the Developing Intestine and during Necrotizing Enterocolitis. Seminars in Perinatology; 2017 Feb; 41(1): 52-60

Patents

Preclinical Model of Neonatal Necrotizing Enterocolitis
Patent # US 10,973,932 B2 | 

Activities & Honors

Honors

  • Basic Science Research Award, Society of Pediatric Research, 2017

Memberships

  • Society for Pediatric Research (SPR) 2019
  • American Physiological Society (APS), 2019
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