Research Summary
Mohan Krishnan’s research interests focus on the inflammatory mechanisms of neonatal necrotizing enterocolitis (NEC), specifically on red blood cell (RBC) transfusion-associated NEC. Dr. Krishnan is currently the PI of NIH-R21 project entitled "RBC transfusion in anemic neonates leads to systemic inflammatory response syndrome" and PI (interim) of two NIH-R01 project entitled "Effect of Platelet Transfusions on Neonatal Intestinal Injury". Dr. Krishnan is interested in the role of monocyte/macrophage in NEC pathogenesis, developed a preclinical mouse model of RBC transfusion-associated NEC and recently published in Nature Communications. This novel model of transfusion-associated NEC is the first preclinical model of transfusion effects in the neonatal intestine and has been awarded a provisional patent. He laid the groundwork for these preclinical models to understand the mechanism(s) by which anemia-transfusion causing gut/systemic inflammation in neonates, a critical step in the development of novel anti-inflammatory therapies that can prevent/ameliorate tissue damage. By focusing on red blood cell biology and transfusion medicine, he increasingly appreciates shared molecular mechanisms driving transfusion-associated adverse effects such systemic inflammatory response syndrome (SIRS) and NEC.
Selected Publications
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MohanKumar K, Namachivayam K, Song T, Nithya S, Cha BJ, Mong E, Alves NG, Jain HT, Breslin JW, Torres BA, and Maheshwari A. Severe Anemia in Pre-Weaned Mice Increases Gut Mucosal Permeability by Disrupting Epithelial Adherens Junctions. American Journal of Physiology-Gastrointestinal and Liver Physiology 2020 Apr 1;318(4):G705-G716
Namachivayam K, MohanKumar K, Shores DR, Jain SK, Fundora J, Everett AD, He L, Pan H, Wickline SA and Maheshwari A. Targeted Inhibition of Thrombin attenuates murine neonatal Necrotizing Enterocolitis. Proc Natl Acad Soc 2020. 117(20):10958-10969
MohanKumar K, Namachivayam K, Song T, Cha BJ, Slate A, Hendrickson JE, Pan H Wickline SA, Oh JY, Patel RP, Torres BA, Maheshwari A. A Novel Murine Model of Necrotizing Enterocolitis Caused by Anemia and Red Blood Cell Transfusion. Nature Communications; 2019; Aug 2;10(1):3494. Doi: 10.1038/s41467-019-11199
MohanKumar K, Namachivayam K, Cheng F, Jiang RHY, Torres JF, Torres BA, Maheshwari A. Trinitrobenzene Sulfonic Acid-induced Intestinal Injury in Neonatal Mice Activates Transcriptional Networks Similar to those seen in Human Necrotizing Enterocolitis. Pediatric Research; 2017 Jan; 81 (1) : 99-112
MohanKumar K, Namachivayam K, Ho TTB, Torres BA, Ohls RK, Maheshwari A. Cytokines and Growth Factors in the Developing Intestine and during Necrotizing Enterocolitis. Seminars in Perinatology; 2017 Feb; 41(1): 52-60
Patents
Preclinical Model of Neonatal Necrotizing Enterocolitis
Patent # US 10,973,932 B2 |
