Mohammad Rezaee, Ph.D., M.Sc.

Headshot of Mohammad Rezaee
  • Assistant Professor of Radiation Oncology and Molecular Radiation Sciences

Research Interests

Radiation Physics and Biophysics, Medical Physics

Background

Dr. Mohammad Rezaee is an assistant professor of radiation oncology and molecular radiation sciences at the Johns Hopkins University School of Medicine. His area of expertise is in medical physics and radiation biophysics.

Upon completion of undergraduate studies in radiological sciences and MSc in medical physics, Dr. Rezaee worked in life sciences industry for 8 years and implemented several industrial projects to validate and modernize various processes in hospitals, biological and pharmaceutical centers. He then completed his PhD study in Radiation Sciences and Biomedical Imaging in the University of Sherbrook in Canada. After graduate studies and postdoctoral training, Dr. Rezaee joined the Medical Physics Residency Program at Princess Margaret Cancer Centre in the University of Toronto and received his clinical certificate in therapeutic physics from Canadian College of Physicists in Medicine (CCPM). He had developed the expertise in the field of radiation sciences including physics and biophysics with therapeutic and diagnostic applications during his academic study, postdoctoral and residency training programs.

After completion of his residency, he joined the University Health Network and Acumyn Inc (TECHNA). Dr. Rezaee led Aqua Radiology project, a software platform that automates and unifies all quality assurance activities of medical imaging devices across various medical centers. In 2017, Dr. Rezaee joined the Department of Radiation Oncology and Molecular Radiation Sciences in the Johns Hopkins University as a clinical physicist.  He has been lead physicist in the brachytherapy program. He is also a member of the Radiation Core and physics advisor of advanced preclinical radiation research at the Sidney Kimmel Comprehensive Cancer Center in the Johns Hopkins University. He has invented an orthovoltage x-ray FLASH irradiation system for preclinical laboratory research on small animals and cell cultures. Dr. Rezaee has developed FLASH radiation research program at the Department of Radiation Oncology and Molecular Radiation Sciences at the Johns Hopkins University School of Medicine.

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Titles

  • Assistant Professor of Radiation Oncology and Molecular Radiation Sciences
  • Assistant Professor of Oncology

Departments / Divisions

Education

Degrees

  • M.Sc.; Mashhad University of Medical Sciences (Iran) (2001)
  • B.Sc.; Shahid Beheshti University of Medical Sciences - Tehran (Iran) (1997)
  • Ph.D.; University of Sherbrooke - Quebec (Canada) (2013)

Additional Training

  • Postdoctoral Fellowship, Radiation Biophysics, University of Sherbrooke, Sherbrooke, QC, Canada (2013)

Research & Publications

Research Summary

My research interest is radiation physics, biophysics, and their exploitation to improve the efficacy of radiation therapy using different methods including FLASH radiotherapy, high-LET charged particles, radiosensitizers, and Auger-electron emitting radionuclides. One of my major focuses is to develop FLASH radiotherapy for preclinical studies, and elucidation of biophysical and biological mechanisms, and its translation into clinical practices. My research program has three main fields of research:

Physics and Biophysics – researches in this field includes dosimetry of ultrahigh dose-rate (FLASH) kV x-ray irradiation system and FLASH proton beam, development of Monte-Carlo dose engine for preclinical radiation research and physicochemical/chemical processes in high-LET charged particles and FLASH radiotherapy, and development of molecular dosimeters.

Biology – researches in this field includes investigation of early biological events (e.g. DNA damage formation) induced by high-LET charged particles and FLASH irradiation, normal and tumor cell responses to these radiations, and their combination with chemotherapeutic agents,

Clinical Translation – Researches in this field focus on the translation of FLASH radiotherapy into clinic for both superficial and deep-seated tumors using kV x-rays and MeV proton FLASH beams, development of treatment planning system, and quality assurance of ultrahigh dose-rate irradiation systems.

Selected Publications

M Rezaee, I Iordachita, JW Wong, (2021). Ultrahigh dose-rate (FLASH) x-ray irradiator for pre-clinical laboratory research, Physics in Medicine & Biology 66 (9), 095006.

M Rezaee, RP Hill, DA Jaffray, (2017). The Exploitation of Low-Energy Electrons in Cancer Treatment. Radiation research 188 (2), 123-143.

M Rezaee, DJ Hunting, L Sanche, (2013). New insights into the mechanism underlying the synergistic action of ionizing radiation with platinum chemotherapeutic drugs: the role of low-energy electrons. International Journal of Radiation Oncology* Biology* Physics 87 (4), 847-853.

M Rezaee, L Sanche, DJ Hunting, (2013). Cisplatin enhances the formation of DNA single-and double-strand breaks by hydrated electrons and hydroxyl radicals. Radiation research 179 (3), 323-331.

M Rezaee, P Cloutier, AD Bass, M Michaud, DJ Hunting, L Sanche, (2012). Absolute cross section for low-energy-electron damage to condensed macromolecules: A case study of DNA. Physical Review E 86 (3), 031913.

Patents

An ultra-high (FLASH) dose rate x-ray cabinet system for pre-clinical laboratory radiation research
Patent # US2021/055294 | 

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